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1.
J Clin Med ; 11(11)2022 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-35683374

RESUMO

Background: Coffee is one of the most popular beverages globally and contains several bioactive compounds that are relevant to human health. Many nutritional strategies modulate sirtuin-1, thereby impacting aging and cardiometabolic health. This study investigated the influence of different blended coffees on serum sirtuin-1, blood lipids, and plasma homocysteine. Methods: An eight-week randomized clinical trial that included 53 healthy adults of both sexes analyzed the effects of daily intake of 450 to 600 mL of pure Arabica or blended (Arabica + Robusta) coffee intake of filtered coffee on blood sirtuin-1, lipids, and homocysteine. Results: Both Arabica and blended coffees similarly increased serum sirtuin-1 concentration, from 0.51 to 0.58 ng/mL (p = 0.004) and from 0.40 to 0.49 ng/mL (p = 0.003), respectively, without changing plasma homocysteine, folic acid, glucose, and CRP. However, the blended coffee intake increased total cholesterol from 4.70 to 5.17 mmol/L (p < 0.001) and LDL-cholesterol from 2.98 to 3.32 mmol/L (p < 0.001), as well as HDL-c from 1.26 to 1.36 mmol/L (p < 0.001). Conclusion: Both coffee powders increased sirtuin-1 expression, but our results suggest that blended coffee had hypercholesterolemic effects which could increase cardiovascular risk. Therefore, preference should be given to Arabica coffee for the best cardiometabolic benefits of coffee.

2.
Arq Bras Cardiol ; 81(3): 229-8, 2003 Sep.
Artigo em Inglês, Português | MEDLINE | ID: mdl-14569368

RESUMO

OBJECTIVE: To assess whether a difference exists in coronary heart disease clinical manifestations and the prevalence of risk factors between Japanese immigrants and their descendents in the city of São Paulo. METHODS: Retrospective analysis of coronary artery disease clinical manifestations and the prevalence of risk factors, comparing 128 Japanese immigrants (Japanese group) with 304 Japanese descendents (Nisei group). RESULTS: The initial manifestation of the disease was earlier in the Nisei group (mean=53 years), a difference of 12 years when compared with that in the Japanese group (mean=65 years) (P<0.001). Myocardial infarction was the first manifestation in both groups (P=0.83). The following parameters were independently associated with early coronary events: smoking (OR=2.25; 95% CI=1.35-3.77; P<0.002); Nisei group (OR=10.22; 95% CI=5.64-18.5; P<0.001); and female sex (OR=5.04; 95% CI=2.66-9.52; P<0.001). CONCLUSION: The clinical presentation of coronary heart disease in the Japanese and their descendents in the city of São Paulo was similar, but coronary heart disease onset occurred approximately 12 years earlier in the Nisei group than in the Japanese group.


Assuntos
Doença das Coronárias/etnologia , Adulto , Idade de Início , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Feminino , Humanos , Hipercolesterolemia/etnologia , Hipertrigliceridemia/epidemiologia , Japão/etnologia , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Retrospectivos , Fatores de Risco
3.
Arq. bras. cardiol ; 81(3): 229-238, set. 2003. tab, graf
Artigo em Português, Inglês | LILACS | ID: lil-347437

RESUMO

OBJECTIVE: To assess whether a difference exists in coronary heart disease clinical manifestations and the prevalence of risk factors between Japanese immigrants and their descendents in the city of Säo Paulo. METHODS: Retrospective analysis of coronary artery disease clinical manifestations and the prevalence of risk factors, comparing 128 Japanese immigrants (Japanese group) with 304 Japanese descendents (Nisei group). RESULTS: The initial manifestation of the disease was earlier in the Nisei group (mean = 53 years), a difference of 12 years when compared with that in the Japanese group (mean = 65 years) (P<0.001). Myocardial infarction was the first manifestation in both groups (P = 0.83). The following parameters were independently associated with early coronary events: smoking (OR = 2.25; 95 percent CI = 1.35-3.77; P<0.002); Nisei group (OR = 10.22; 95 percent CI = 5.64-18.5; P<0.001); and female sex (OR = 5.04; 95 percent CI = 2.66-9.52; P<0.001). CONCLUSION: The clinical presentation of coronary heart disease in the Japanese and their descendents in the city of Säo Paulo was similar, but coronary heart disease onset occurred approximately 12 years earlier in the Nisei group than in the Japanese group


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Doença das Coronárias , Idade de Início , Idoso de 80 Anos ou mais , Brasil , Hipercolesterolemia , Hipertrigliceridemia , Japão , Prevalência , Estudos Retrospectivos , Fatores de Risco
4.
São Paulo; s.n; 2002. 75 p. ilus, tab, graf.
Tese em Português | LILACS | ID: lil-403654

RESUMO

No presente estudo foi analisado o perfil da doença coronariana em imigrantes de origem japonesa e de seus descendentes na cidade de São Paulo, quantoà apresentação clínica e fatores de risco associados. A manifestação inicial da doença ocorreu mais cedo nos nisseis, e a diferença observada foi de 12 anosquando comparada com os imigrantes japoneses. Houve maior prevalência de hipercolesterolemia e maior média do índice de massa corpórea nasmulheres do grupo nissei...


Assuntos
Humanos , Masculino , Feminino , Adulto , Doença das Coronárias/epidemiologia , Emigração e Imigração/classificação , Perfil de Impacto da Doença , Hipercolesterolemia/epidemiologia , Estudos Prospectivos , Fatores de Risco
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