RESUMO
We report on two brothers with adult polycystic kidney disease, malignant teratomas and other genital malformations. Because of the unusual accumulation of malformations of embryologically related organs, we postulate a connection between malformations of the kidneys and the genital tract, on the one hand, and teratomas on the other. No genetic coherence is known so far. It is unlikely that immunosuppression with cyclosporin after transplantation had caused these tumours.
Assuntos
Ciclosporinas/efeitos adversos , Transplante de Rim/imunologia , Doenças Renais Policísticas/genética , Complicações Pós-Operatórias/induzido quimicamente , Neoplasias Retroperitoneais/induzido quimicamente , Teratoma/induzido quimicamente , Neoplasias Testiculares/induzido quimicamente , Adulto , Ciclosporinas/administração & dosagem , Feminino , Humanos , Transplante de Rim/patologia , Masculino , Pessoa de Meia-Idade , Músculos/patologia , Linhagem , Doenças Renais Policísticas/cirurgia , Complicações Pós-Operatórias/patologia , Complicações Pós-Operatórias/cirurgia , Neoplasias Retroperitoneais/patologia , Neoplasias Retroperitoneais/cirurgia , Teratoma/patologia , Teratoma/cirurgia , Neoplasias Testiculares/patologia , Neoplasias Testiculares/cirurgia , Testículo/patologiaRESUMO
Epidermal growth factor receptor (EGF-R) was estimated in Hypernephroma by saturation analysis using 125-I EGF as ligand. Tissue levels of this oncogene related protein were increased five-fold (24 to 99 fmol/mg protein) in comparison with the surrounding tumor free tissue (3 to 18 fmoles/mg protein). There was no apparent correlation to the stage of tumor growth or tumor differentiation and there was no correlation of EGF serum levels with tumor growth. EGF serum levels in the tumor patients did not exceed levels in control patients.
