Role of information and communication technology, economic growth, financial development and renewable energy consumption towards the sustainable environment: Insights from ASEAN countries.

The objective of this study is to examine the effect of information and communication technology, economic growth, renewable energy consumption, and financial development on carbon dioxide emissions in selected ASEAN countries. The PMG (Pooled Mean Group) estimator is used to panel data from 1991 to 2020 to examine both the short-run and long-run impacts. The findings indicate that ICT and financial development contribute to environmental deterioration, in the long run, their influence on CO2 emissions in the short run is insignificant. On the other hand, the use of renewable energy has a long- and short-term favorable impact on environmental quality. Furthermore, it is discovered that economic growth increases CO2 emissions, but squared economic growth reduces CO2 emissions, confirming the inverted U-shaped EKC theory. The Granger causality test indicates that renewable energy and CO2 emissions are bidirectionally causal, but information and communication technology and financial development are unidirectionally causal to CO2 emissions. According to the findings, the governments of these nations must reduce carbon emissions from internet usage and invest in renewable energy sources to control environmental deterioration.

The role of renewable, non-renewable energy consumption, trade, economic growth, and urbanization in achieving carbon neutrality: A comparative study for South and East Asian countries.

This study uses a comparative approach for comparing the nexus of economic growth, renewable and nonrenewable energy consumption, urbanization, trade, and CO2 emissions for South and East Asian countries from 2000 to 2018. The short- and long-run connections between the variables are explored using the dynamic common correlated effects (DCCE) CS-ARDL approach, and the causal linkages are assessed using the Dumitrescu-Hurlin (DH) panel causality test. The data show that the factors have long-term relationships. The findings show that nonrenewable energy consumption and economic growth increase long-term CO2 emissions in South Asia, but trade and use of renewable energy consumption reduce CO2 emissions in the short term. Long-term causal relationships between CO2 emissions, renewable energy use, economic growth, and trade are also revealed by the South Asian causality test. In East Asia, economic growth, NREC, trade, and urbanization increased CO2 emissions in the short and long run, while REC appears to reduce CO2 emissions. According to the causality analysis, long-run bidirectional causation exists between CO2 emissions, renewable energy use, economic growth, and trade. Furthermore, policy suggestions may be made, such as using renewable energy sources to lessen CO2 emissions and improving education and corruption to forecast economic growth in the examined areas.

Validation of the English and Swahili Adaptation of the Patient Health Questionnaire-9 for Use Among Adolescents in Kenya.

PURPOSE: Our study aimed to validate culturally adapted English and Swahili versions of the Patient Health Questionnaire-9 (PHQ-9) for use with adolescents in Kenya. Criterion validity was determined with clinician-administered diagnostic interviews using the Kiddie Schedule of Affective Disorders and Schizophrenia. METHODS: A total of 250 adolescents comprising 148 (59.2%) females and 102 (40.8%) males aged 10-19 years (mean = 14.76; standard deviation = 2.78) were recruited. The PHQ-9 was administered to all respondents concurrently in English and Swahili. Adolescents were later interviewed by clinicians using Kiddie Schedule of Affective Disorders and Schizophrenia to determine the presence or absence of current symptoms of major depressive disorder. Sensitivity specificity, positive predictive value (PPV) and negative predictive value (NPV), and likelihood ratios for various cut-off scores for PHQ-9 were analyzed using receiver operating characteristic curves. RESULTS: The internal consistency (Cronbach's α) for PHQ-9 was 0.862 for the English version and 0.834 for Swahili version. The area under the curve was 0.89 (95% confidence interval, 0.84-0.92) and 0.87 (95% confidence interval, 0.82-0.90) for English and Swahili version, respectively, on receiver operating characteristic analysis. A cut-off of ≥ 9 on the English-language version had a sensitivity of 95.0%, specificity of 73.0%, PPV of 0.23, and NPV of 0.99; a cut-off of ≥ 9 on the Swahili version yielded a sensitivity of 89.0%, specificity of 70.0%, PPV of 0.20, and NPV of 0.90. DISCUSSION: Psychometric properties were comparable across both English-adapted and Swahili-adapted version of the PHQ-9, are reliable, and valid instrument to detect major depressive disorder among adolescents which can be used in resource-limited settings for early identification of adolescents in need of mental health support.

Does sectoral modernization promote CO2 emissions? Dynamic panel analysis of selected Asian countries.

Modernization refers to the general process of progress within human societies. As a result of carbon dioxide emissions, global warming poses a significant threat to human sustainability. Therefore, the scientific community must thoroughly research the impact of modernization on CO2 emissions. Surprisingly, just a few pieces of research have previously examined this subject. Asian economies are regarded as laggards in achieving the Sustainable Development Goals (SDGs), with environmental degradation being one of the key issues confronting these countries. This study used panel data regression to investigate the association between sectoral modernization and CO2 emissions in South Asia. None of the existing studies has observed the sectoral modernization and CO2 emission nexus in the region of South Asia. Therefore, this study bridges the research gap in the current literature. This study found that social sector transformation, energy sector, and services sector modernization have negative associations with CO2 emissions in South Asia. However, both the agricultural sector and industrial sector modernization are positively associated with CO2 emissions in South Asia. The empirical results from several models suggest that sectorial modernization has a significant and strong association with environmental sustainability. Access to a green and eco-friendly economy can increase modernization among different sectors of the economy to produce pro-environment products and society. Also, we found that FDI and trade policies influence the economies to follow environment-friendly economic practices.

Dynamic linkages of financial inclusion, modernization, and environmental sustainability in South Asia: a panel data analysis.

This study explores the dynamic linkages of financial inclusion, modernization, and environmental sustainability in South Asia during the period 1998-2019. Two distinct composite indexes for financial inclusion and modernization are developed by using principal component analysis (PCA) based on normalized indicators. To examine the dynamic linkages, we adopted panel regression models that are not only robust but also heteroskedasticity consistent. We find that financial inclusion, modernization, per capita GDP, and FDI appear to lead to higher CO2 emissions in the South Asian region. Meanwhile, increased economic integration and trade openness appear to have negative dynamics for carbon emissions. These empirical findings are unbiased and robust to different reasonable modifications to panel data model specifications. This study comes up with the conclusion that presently there is no policy coherence and coordination between growing financial inclusion, modernization, and carbon mitigation strategies in South Asia. Thus, the prospect of financial inclusion and modernization should be cohesive into comprehensive climate change mitigation strategies at regional, national, and global levels, specifically to mitigate the adverse dynamics of higher carbon emissions associated with modern development.

Is serum level of methylated RASSF1A valuable in diagnosing hepatocellular carcinoma in patients with chronic viral hepatitis C?

BACKGROUND AND STUDY AIMS: The detection of the promoter hypermethylation of RASSF1A in serum DNA could be a valuable biomarker for early detection of preneoplastic lesions and early cancer development among high-risk populations who are at a high risk of hepatocellular carcinoma (HCC). Therefore, we aimed determining the serum level of methylated RASSF1A sequence in patients with chronic hepatitis C viral infection and to evaluate the predictive value of it as a diagnostic marker for HCC in patients with chronic hepatitis C viral infection. PATIENTS AND METHODS: Serum levels of methylated RASSF1A were detected and measured using real-time PCR after digestion with a methylation-sensitive restriction enzyme in 40 patients with chronic HCV infection, 40 patients with HCC (on top of HCV) and 20 controls. RESULTS: Methylated RASSF1A was detected in 10% of the controls, 62.5% of HCV group and in 90% of HCC group. Chronic HCV patients had insignificantly higher levels than the controls. The levels were significantly higher in patients with HCC compared to the controls (p=0.0001) and chronic HCV patients (p=0.001). By logistic regression analysis, the serum methylated RASSF1A was found to differentiate HCC patients from healthy controls with an AUROC of 0.83nmol/L, and an overall predictive accuracy of 77.5%. It was able to differentiate patients with HCC from those with chronic HCV infection alone with an AUROC of 0.733 and an overall predictive accuracy of 72.5%. CONCLUSION: The mean serum levels of methylated RASSF1A could be of value for early diagnosis of HCC especially in high risk patients with HCV infection.

Can serum fibrosis markers predict medium/large oesophageal varices in patients with liver cirrhosis?

BACKGROUND AND STUDY AIMS: Non-invasive predictors of medium/large oesophageal varices (LOVs) could reduce the number of screening endoscopies. As portal hypertension is a consequence of liver fibrosis, serum fibrosis markers were evaluated together with other variables as possible non-invasive predictors of medium OV/LOV. PATIENTS AND METHODS: A total of 154 cirrhotic patients with splenomegaly and 30 healthy control subjects were recruited in a prospective study in two gastroenterology centres in Upper Egypt. Clinical parameters assessed included Child-Pugh class, liver size and ascites. Laboratory parameters included complete blood count, liver function tests, and aspartate aminotransferase (AST)/platelet ratio. Transforming growth factor-ß(1) (TGF-ß(1)), alpha(2) macroglobulin (A(2)M) and hyaluronic acid (HA) were assayed. Ultrasonographic examination was done for assessment of liver span, portal vein diameter and detection of minimal ascites. Oesophageal varices were diagnosed and graded by oesophagogastroduodenoscopy. RESULTS: Fifty-four patients (35%) had no or small varices and 100 (65%) patients had medium OV/LOV by endoscopy. On multivariate analysis, the independent predictors of medium OV/LOV were the presence of ascites (ß=0.258, p=0.047) and serum HA (ß=0.449, p=0.009). The receiver operating characteristic curve for HA showed the area under the curve to be 0.916. The sensitivity, specificity, positive and negative predictive values and diagnostic accuracy of HA at a cut-off value of 207µgl(-1) were 94%, 77.8%, 88.7%, 87.5% and 88.3%, respectively. CONCLUSIONS: The presence of ascites and serum HA level higher than 207µgl(-1) can predict the presence of medium OV/LOV in cirrhotic patients. This would help physicians to identify patients who would most likely benefit from screening endoscopy and thus, reduce costs and discomfort from unnecessary endoscopic procedures.

Monocyte-platelet aggregates and platelet micro-particles in patients with post-hepatitic liver cirrhosis.

INTRODUCTION: Monocytes are the cells that play a crucial role in the pathogenesis of liver damage and liver cirrhosis (LC), and as platelets, by connecting hemostasis and inflammatory processes, participate in pathogenesis of chronic liver diseases, we aimed to investigate the presence of monocyte-platelet aggregates and platelet micro-particles (PMPs) and their role in LC. PATIENTS AND METHODS: The study included 60 patients with post-hepatitic LC and 20 healthy controls. Activated monocytes (CD11b, HLA-DR, CD14, CD16), monocyte-platelet aggregates (CD41/CD14), activated platelets (CD41/CD62) and PMPs were analyzed by flow cytometry. Their relations to the clinical and laboratory data were assessed in the studied group. RESULTS: Patients with LC had higher levels of activated platelets, activated monocytes and monocyte-platelet aggregations as compared to healthy controls. PMPs percentage showed no significant differences between patients and controls but significantly increased in both patients with no bleeding and patients with splenomegaly compared to patients without. All studied markers showed no significant differences between patients with thrombocytopenia and those with normal platelet counts and also between patients with different disease stages. Positive correlations between monocyte-platelet aggregates and both activated platelets and monocytes were demonstrated. There were significant negative correlations between PMPs and both age and prothrombin time among patients. CONCLUSIONS: The stage of post-hepatitic LC is not the only factor that affects the level of activated platelets, activated monocytes and monocyte-platelet aggregates. PMPs have no influence on thrombocytopenia but may have the potential to influence the progression of clotting activity in LC.