The relationship of air pollution and surrogate markers of endothelial dysfunction in a population-based sample of children.

BACKGROUND: This study aimed to assess the relationship of air pollution and plasma surrogate markers of endothelial dysfunction in the pediatric age group. METHODS: This cross-sectional study was conducted in 2009-2010 among 125 participants aged 10-18 years. They were randomly selected from different areas of Isfahan city, the second large and air-polluted city in Iran. The association of air pollutants' levels with serum thrombomodulin (TM) and tissue factor (TF) was determined after adjustment for age, gender, anthropometric measures, dietary and physical activity habits. RESULTS: Data of 118 participants was complete and was analyzed. The mean age was 12.79 (2.35) years. The mean pollution standards index (PSI) value was at moderate level, the mean particular matter measuring up to 10 µm (PM10) was more than twice the normal level. Multiple linear regression analysis showed that TF had significant relationship with all air pollutants except than carbon monoxide, and TM had significant inverse relationship with ozone. The odds ratio of elevated TF was significantly higher in the upper vs. the lowest quartiles of PM10, ozone and PSI. The corresponding figures were in opposite direction for TM. CONCLUSIONS: The relationship of air pollutants with endothelial dysfunction and pro-coagulant state can be an important factor in the development of atherosclerosis from early life. This finding should be confirmed in future longitudinal studies. Concerns about the harmful effects of air pollution on children's health should be considered a top priority for public health policy; it should be underscored in primordial and primary prevention of chronic diseases.

Determinants of tobacco use among youths in Isfahan, Iran.

OBJECTIVE: To determine potential factors that may result in motivating the youths to adopt smoking behaviour. METHOD: This cross-sectional study was conducted on 210 smoking and 217 non-smoking youths, aged 12-20 years. RESULTS: The average age of starting cigarette and water pipe smoking was 14.5 +/- 2.4 and 11.2 +/- 1.5 years, respectively. The first experience with water pipe occurred mostly in the traditional teahouses for girls (54.8%), and in family parties (48.2%) for boys. In both genders, the first place of cigarette smoking was at friends' parties (56.8% for boys, and 52.1% for girls) and then followed by traditional teahouses (43.2% for boys, and 47.9% for girls). The most common reasons youths have picked up cigarette smoking were mainly to attract attention from friends, family inattention and poverty. Meanwhile, nearly all water pipe smokers reported using it for fun. The strongest predictors of smoking among boys were respectively father's occupation, having a smoking mother, and the number of smoking peers, whereas among girls, these factors were respectively having a smoking mother, frequenting traditional teahouses, and the number of smoking peers. Lower education of fathers and divorce among parents increased the probability of smoking in both genders, especially girls. School/work failure, as well as troubled relationship with parents and siblings were the other significant predictors of smoking in both genders, notably in girls. CONCLUSION: Public health control measures should be adopted not only to curtail cigarette use, but also to address water-pipe use. Preventive measures should be regarded as a high priority for socio-economically disadvantaged families.