[Effect of probiotic product containing bifidobacteria and biogel from brown algae on the intestinal microflora and parameters of innate immunity in mice with experimental drug dysbacteriosis].

The article represents the results of studying the effect of a new fermented product (FP) containing the probiotic strain Bifidobacterium bifidum 791 and Biogel from brown algae Laminariajaponica on the composition of intestinal microflora and parameters of innate immunity in mice with experimental dysbacteriosis, induced by administration of gentamicin in dose of 25 mg per kg body weight during 7 days. The experimental animals received for 6 weeks in addition to the diet FP, which was 2% of the average volume of feed intake. The FP influence was manifested by more rapid reduction of dyspepsia symptoms, restoration of body weight and balance the intestinal microbiocenosis (increasing of bifido- and lactobacteria, typical E. coli, reducing of the bacteria genus Proteus and Clostridium, elimination of S. aureus). As the results of FP administration we observed the statistically significant reduction of endogenous intoxication values and increasing of the phagocyte activity of neutrophils, related to effector cells of innate immunity, compared with animals not receiving FP. Identified effects of FP are due to both its probiotic properties through the presence of bifidobacteria and immunomodulating and enteral sorbtion activities of alginate component.

[Functional properties of alginates and their use in therapeutic-prophylactic nutrition]. / Funktsional'nye svoistva al'ginatov i ikh ispol'zovanie v lechebno-profilakticheskom pitanii.

Adsorbability of alginic acid and its salts extracted from brown seaweeds and character of their biological action were studied. The results of clinical tests alginic acid and its salts as well as of preparations and food-stuffs, prepared from Laminaria japonica Arech, were reflected. The potentialities of use of alginates and food-stuffs containing them in therapeutic nutrition was shown.

[Effect of alginic acid and its salts on the dynamic of 85Sr and 137Cs accumulation in rats]. / Vliianie al'ginovoi kisloty i ee solei na dinamiku nakopleniia 85Sr i 137Cs v organizme krys.

Accumulation of 85Sr and 137Cs radionuclide blend in rats was studied. Effect of alginic acid, its salts as well as foods containing the polysaccharides on dynamics of accumulation was established. It was shown that efficiency of compounds studied depends on type of salt of alginic acid and presence of guluronic acid in it.