The Effect of Using Ofloxacin Ear Drops in Traumatic Tympanic Membrane Healing: A Systematic Review and Meta-Analysis.

Objectives: To evaluate the effectiveness of ofloxacin ear drops versus no intervention in the repair of traumatic tympanic membrane (TM) perforations from randomized controlled trials (RCTs). Data Sources: Medline/PubMed, CENTRAL, Clinical Trials.Gov, and Google Scholar. Study Selection: Inclusion criteria: (1) English language; (2) RCT studies; (3) reported the outcomes on the application of ofloxacin and outcomes of spontaneous healing. Exclusion criteria: (1) studies without a control group; (2) patient with severe otologic disease such as chronic suppurative otitis media or ossicular disruption or patients with craniocerebral injury; (3) studies with no pretreatment values or single-arm clinical studies. Data Extraction: Country, year of publication, number of participants in each arm, patient characteristics such as age, sex, intervention details, laterality, cause of TM perforation, position of perforation, follow-up time, hearing gain, rate of TM closure, and closure time. Results: A total of 6 RCTs studies were analyzed. A total of 502 participants were included; the relative risk for closure rate of ofloxacin treatment was 1.18 [95% confidence interval (CI), 1.08 to 1.28, P < .001] and the mean difference (MD) for healing time was -18.4 (95% CI, -19.96 to -16.82, P < .001), suggesting ofloxacin has a significant effect on closure of TM perforations. However, no clinically significant effect in hearing (SMD: 0.21, 95% CI, 0.02 to 0.40, P = .03) was seen in ofloxacin group. Also, patients in the ofloxacin group were associated with a 13% reduction in the risk of infections compared to their observation-assigned counterparts, but this estimate was not statistically significant. Conclusion: Ofloxacin use in patients with traumatic TM perforation is effective in reducing healing time and increasing rate of TM perforation closure. No evidence of increased risk of hearing loss or infection rates are encountered when ofloxacin is prescribed to patients with traumatic TM perforation.

Results with cochlear implantation in adults with speech recognition scores exceeding current criteria.

OBJECTIVES: The primary purpose of this study was to evaluate a group of postlingually deafened adults, whose aided speech recognition exceeded commonly accepted candidacy criteria for implantation. The study aimed to define performance and qualitative outcomes of cochlear implants in these individuals compared with their optimally fitted hearing aid(s). STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral center. PATIENTS: All postlingually deafened subjects (N = 27), who were unsuccessful hearing aid users implanted between 2000 and 2010 with a preimplantation Hearing in Noise Test (HINT) score of 60% or more were included. INTERVENTION: We compared patients' preoperative performance (HINT score) with hearing aids to postoperative performance with the cochlear implant after 12 months of device use. In addition, the Hearing Handicap Inventory questionnaire was used to quantify the hearing-related handicap change perceived after the implantation. RESULTS: The study group demonstrated significant postoperative improvement on all outcome measures; most notably, the mean HINT score improved from 68.4% (standard deviation, 8.3) to 91.9% (standard deviation, 9.7). Additionally, there was a significant improvement in hearing-related handicap perceived by all patients. CONCLUSION: The envelope of implantation candidacy criteria continues to expand as shown by this study's cohort. Patient satisfaction and speech recognition results are very encouraging in support of treating those who currently perform at a level above the conventional candidacy threshold but struggle with optimally fitted hearing aids.

Cochlear implant rehabilitation for patients with vestibular schwannoma: report of two cases.

OBJECTIVE AND IMPORTANCE: The objective of this paper is to highlight two main points. The primary aim is to demonstrate that cochlear implants can function in the presence of retrocochlear pathology, even after stereotactic radiosurgery (SRS), and hence to introduce this as a management option in selected patients with retrocochlear pathology, such as Neurofibromatosis type II (NFII) patients. A secondary aim is to act as a caveat that computed tomography (CT) scanning alone may not be sufficient imaging in subjects undergoing cochlear implantation (CI). CLINICAL PRESENTATION: In this paper we report two patients who underwent cochlear implant despite the presence of a vestibular schwannoma (VS) on the same side. The first case is a 59-year-old male, diagnosed with VS after 9 months of good hearing with a cochlear implant. The second case is 26-year-old female known case of NFII, received a cochlear implant after controlling the tumor growth with a SRS. CONCLUSION: We show the consequences of missing important pre-implant pathology prior to CI in one case. In both cases, we add to the literature showing that cochlear implants can work well in the presence of VS, even in the presence of previous SRS. This adds significantly to the management options available to NFII patients, and the results seem to be better than those expected for auditory brainstem implant (ABI), and with a much simpler and safer intervention.

Anatomic analysis of the mastoid tegmen: slopes and tegmen shape variances.

OBJECTIVES: To examine the dural slope shapes and slope depths in different axes in the mastoid. These are important for surgical guidance. STUDY DESIGN: Setting-Tertiary care otologic center. Patients/materials-105 temporal bone CT scans were used from subjects who had undergone High Resolution Temporal Bone CT scanning for CSOM, using the non-diseased ear scans. In addition, 21 "diseased side" temporal bones were included. INTERVENTIONS: Scans were reconstructed in 3D using Amira software to examine tegmen shapes. The highest and lowest points on the tegmen were measured along 4 axes, 2 in the coronal plane (latero-medial axes posteriorly and anteriorly [L-M ant and L-M post]), and 2 in the sagittal plane (posterio-anterior axes medially and laterally [P-A med and P-A lat]). MAIN OUTCOME MEASURES: The highest and lowest point difference was labeled ΔH. We also measured the height from the superior external canal to the tegmen. RESULTS: There was a unimodal distribution in the ΔH variable for all axes measured. Means and (SD) in mm for ΔH are as follows: L-M post 4.1 (2), L-M ant 2.9 (2.2), P-A med 6.5 (1.9), P-A lat 5.4 (2.2). Tegmen-EAC lat and med height means were 8.4 and 9.7 mm respectively. Representative 3D shapes are presented. CONCLUSION: There appears to be a unimodal distribution of mastoid tegmen shapes and sizes, without clustering into subpopulations. The tegmen slopes have real implications for surgical exploration and disease eradication. A Tegmen classification scheme is presented.

The effects of unilateral cochlear implantation on the tinnitus handicap inventory and the influence on quality of life.

OBJECTIVES/HYPOTHESIS: Cochlear implantation is now the standard of care in patients with significant sensorineural hearing loss. It is well known that patients with severe hearing loss also experience disabling tinnitus. The purpose of this study was to assess the effects of cochlear implants on the perception of tinnitus using the Tinnitus Handicap Inventory (THI). STUDY DESIGN: Prospective, longitudinal study of 142 cochlear implant patients. METHODS: The THI was administered to 142 patients pre- and postimplantation. Outcome measures were obtained 12 months after the implantation. Secondary analyses to examine the correlation between changes in THI scores and outcome measures such as Hearing Handicap Inventory, Hearing in Noise Test (HINT), and short-form 36 (SF-36) quality-of-life scores were performed. RESULTS: Patients demonstrated statistically significant reduction of the THI scores including its subscales (P < .001). Prior to implantation, 37% of patients described their tinnitus as moderate to severe. Postoperatively, this percentage decreased to 10%. Cochlear implantation resulted in complete tinnitus suppression in 37% and tinnitus reduction in another 29% of patients. THI scores significantly correlated with three domains of the SF-36 quality-of-life questionnaire, namely social, emotional, and general health domains. CONCLUSIONS: Cochlear implants have a significant suppressive effect on tinnitus in 66% of implant users. Although the reduction in the subjectively perceived tinnitus was statistically significant, it did not correlate with HINT; however, it did correlate with three quality-of-life domains, more significantly for those whose pretreatment conditions were moderate or worse.

Transmastoid resurfacing of superior semicircular canal dehiscence.

OBJECTIVES/HYPOTHESIS: To describe a new and fast surgical technique in treating superior semicircular canal dehiscence syndrome by resurfacing the canal defect via the transmastoid approach without retraction of the whole temporal lobe and to demonstrate the clinical and audiologic results of the superior canal dehiscence repair. Superior semicircular canal dehiscence syndrome is a well-described pathology. Surgical procedures through the middle fossa approach to resurface the superior canal and transmastoid plugging are considered the main surgical therapeutic options for patients with debilitating symptoms. Both have drawbacks; plugging is invasive to the inner ear, and resurfacing requires a middle fossa approach. STUDY DESIGN: Retrospective review. METHODS: Four patients presented with classic symptomatic semicircular canal dehiscence syndrome with radiographic confirmation of their dehiscence. The patients underwent the resurfacing procedure with a transmastoid approach. RESULTS: All four patients reported resolution of their symptoms. Audiograms documented some improvement in three subjects. CONCLUSIONS: The transmastoid approach for resurfacing superior semicircular canal dehiscence is a safe and less-invasive technique than the standard middle fossa approach, which has many potential complications and requires much longer hospitalization. In our study, the surgeries were completed within 90 minutes, and patients stayed in the hospital only overnight.

Lateral ectopic thyroid goiter with a normally located thyroid.

BACKGROUND: Midline ectopic thyroid tissue is a common pathological entity. In contrast, laterally located ectopic thyroid tissue with a normally located thyroid gland is a very rare condition in head and neck surgery. SUMMARY: We report the association of laterally located multinodular thyroid tissue and a normally located multinodular goiter. A woman was seen in the otolaryngology clinic with a right submandibular mass. Clinical examination and investigations confirmed the presence of a multinodular goiter in an ectopic thyroid gland. CONCLUSION: Laterally located ectopic thyroid tissue is a very rare condition. Ectopic thyroid tissues can undergo the same pathological changes as a normally located thyroid gland. Ectopic thyroid goiter together with a normally located multinodular goiter is a rare entity, and this is the first to be reported in North America.