Patient-Reported Outcome Measures (PROMs) with Refractive and Diffractive Extended Depth of Focus (EDOF) Intraocular Lenses.

BACKGROUND: Extended depth of focus intraocular lenses (EDOF-IOLs) provide unaided far- and mid-range vision. Refractive IOLs, in contrast to diffractive designs, are associated with a lower depth of focus and absence of dysphotopsia. The aim of this study was to assess spectacle independence for far-range, mid-range, and near-vision activities in patients after implantation of refractive or diffractive EDOF-IOLs using patient-reported outcome measures (PROMs) in a real-world setting. PATIENTS AND METHODS: In 2021 and 2022, all patients in a single center referred for bilateral cataract surgery were assigned to 7 experienced cataract surgeons who either bilaterally implanted only a diffractive EDOF-IOL (Carl Zeiss Meditec AG, AT LARA Jena, Germany, three surgeons) or refractive EDOF-IOL (Johnson & Johnson Vision Inc., Tecnis Eyhance Irvine, California, USA, four surgeons) at the surgeon's discretion, with the aim of bilateral emmetropia. Six months after both cataract surgeries, all patients were contacted by telephone and asked to report their outcomes using a structured questionnaire investigating their spectacle usage for various daily activities and their experience with night glare or halos. Inclusion criteria were a normal postoperative visual potential based on the preoperative examination and completion of the questionnaire regarding postoperative visual experience. RESULTS: Of the patients, 514 underwent bilateral cataract surgery aiming for bilateral emmetropia with the implantation of EDOF-IOLs (422 with Tecnis Eyhance and 92 with AT LARA). A complete questionnaire was obtained from 472 (92%) patients, who were included in the study (393 vs. 79). Comparing Tecnis Eyhance with AT LARA IOL, 54 vs. 57% patients were able to perform most of their daily activities without spectacles, 9 vs. 19% reported not being dependent on spectacles at all, 25 vs. 29% reported using their smartphones without spectacles, 15 vs. 49% patients reported experiencing glares or halos at night, and 1 vs.15% with driving disturbance. Overall, 95 vs. 93% patients described themselves as "satisfied" or "highly satisfied" with their IOL. CONCLUSIONS: With both types of EDOF-IOLs, the majority of patients could perform most of their daily activities without spectacles, except reading, and were highly satisfied with their IOLs. Patients with diffractive Zeiss AT LARA EDOF-IOLs were more likely to accomplish unaided near-range visual tasks; however, they were also at a higher risk of experiencing glares or halos at night.

Patient-specific finite-element simulation of the human cornea: a clinical validation study on cataract surgery.

The planning of refractive surgical interventions is a challenging task. Numerical modeling has been proposed as a solution to support surgical intervention and predict the visual acuity, but validation on patient specific intervention is missing. The purpose of this study was to validate the numerical predictions of the post-operative corneal topography induced by the incisions required for cataract surgery. The corneal topography of 13 patients was assessed preoperatively and postoperatively (1-day and 30-day follow-up) with a Pentacam tomography device. The preoperatively acquired geometric corneal topography - anterior, posterior and pachymetry data - was used to build patient-specific finite element models. For each patient, the effects of the cataract incisions were simulated numerically and the resulting corneal surfaces were compared to the clinical postoperative measurements at one day and at 30-days follow up. Results showed that the model was able to reproduce experimental measurements with an error on the surgically induced sphere of 0.38D one day postoperatively and 0.19D 30 days postoperatively. The standard deviation of the surgically induced cylinder was 0.54D at the first postoperative day and 0.38D 30 days postoperatively. The prediction errors in surface elevation and curvature were below the topography measurement device accuracy of ±5µm and ±0.25D after the 30-day follow-up. The results showed that finite element simulations of corneal biomechanics are able to predict post cataract surgery within topography measurement device accuracy. We can conclude that the numerical simulation can become a valuable tool to plan corneal incisions in cataract surgery and other ophthalmosurgical procedures in order to optimize patients' refractive outcome and visual function.

Statistical modeling of the eye for multimodal treatment planning for external beam radiation therapy of intraocular tumors.

PURPOSE: Ocular anatomy and radiation-associated toxicities provide unique challenges for external beam radiation therapy. For treatment planning, precise modeling of organs at risk and tumor volume are crucial. Development of a precise eye model and automatic adaptation of this model to patients' anatomy remain problematic because of organ shape variability. This work introduces the application of a 3-dimensional (3D) statistical shape model as a novel method for precise eye modeling for external beam radiation therapy of intraocular tumors. METHODS AND MATERIALS: Manual and automatic segmentations were compared for 17 patients, based on head computed tomography (CT) volume scans. A 3D statistical shape model of the cornea, lens, and sclera as well as of the optic disc position was developed. Furthermore, an active shape model was built to enable automatic fitting of the eye model to CT slice stacks. Cross-validation was performed based on leave-one-out tests for all training shapes by measuring dice coefficients and mean segmentation errors between automatic segmentation and manual segmentation by an expert. RESULTS: Cross-validation revealed a dice similarity of 95%±2% for the sclera and cornea and 91%±2% for the lens. Overall, mean segmentation error was found to be 0.3±0.1 mm. Average segmentation time was 14±2 s on a standard personal computer. CONCLUSIONS: Our results show that the solution presented outperforms state-of-the-art methods in terms of accuracy, reliability, and robustness. Moreover, the eye model shape as well as its variability is learned from a training set rather than by making shape assumptions (eg, as with the spherical or elliptical model). Therefore, the model appears to be capable of modeling nonspherically and nonelliptically shaped eyes.

Intraoperative localization of tantalum markers for proton beam radiation of choroidal melanoma by an opto-electronic navigation system: a novel technique.

PURPOSE: External beam proton radiation therapy has been used since 1975 to treat choroidal melanoma. For tumor location determination during proton radiation treatment, surgical tantalum clips are registered with image data. This report introduces the intraoperative application of an opto-electronic navigation system to determine with high precision the position of the tantalum markers and their spatial relationship to the tumor and anatomical landmarks. The application of the technique in the first 4 patients is described. METHODS AND MATERIALS: A navigated reference base was attached noninvasively to the eye, and a navigated pointer device was used to record the spatial position of the tantalum markers, the tumor, and anatomical landmarks. Measurement accuracy was assessed on ex vivo porcine eye specimen by repetitive recording of the tantalum marker positions. The method was applied intraoperatively on 4 patients undergoing routine tantalum clip surgery. The spatial position information delivered by the navigation system was compared to the geometric data generated by the EYEPLAN software. RESULTS: In the ex vivo experiments, the maximum repetition error was 0.34 mm. For the intraoperative application, the root mean square error of paired-points matching of the marker positions from the navigation system and from the EYEPLAN software was 0.701-1.25 mm. CONCLUSIONS: Navigation systems are a feasible tool for accurate localization of tantalum markers and anatomic landmarks. They can provide additional geometric information, and therefore have the potential to increase the reliability and accuracy of external beam proton radiation therapy for choroidal melanoma.

Real-time multimodal retinal image registration for a computer-assisted laser photocoagulation system.

An algorithm for the real-time registration of a retinal video sequence captured with a scanning digital ophthalmoscope (SDO) to a retinal composite image is presented. This method is designed for a computer-assisted retinal laser photocoagulation system to compensate for retinal motion and hence enhance the accuracy, speed, and patient safety of retinal laser treatments. The procedure combines intensity and feature-based registration techniques. For the registration of an individual frame, the translational frame-to-frame motion between preceding and current frame is detected by normalized cross correlation. Next, vessel points on the current video frame are identified and an initial transformation estimate is constructed from the calculated translation vector and the quadratic registration matrix of the previous frame. The vessel points are then iteratively matched to the segmented vessel centerline of the composite image to refine the initial transformation and register the video frame to the composite image. Criteria for image quality and algorithm convergence are introduced, which assess the exclusion of single frames from the registration process and enable a loss of tracking signal if necessary. The algorithm was successfully applied to ten different video sequences recorded from patients. It revealed an average accuracy of 2.47 ± 2.0 pixels (∼23.2 ± 18.8 µm) for 2764 evaluated video frames and demonstrated that it meets the clinical requirements.

Long-term results of vertical rectus muscle transposition and botulinum toxin for sixth nerve palsy.

PURPOSE: To report the long-term outcome of full-tendon vertical rectus muscle transposition combined with chemodenervation of the ipsilateral medial rectus muscle for acquired chronic sixth (abducens) nerve palsy. METHODS: A retrospective study of all patients treated for severe abduction deficit with transposition plus botulinum toxin over the course of 11 years. Minimum follow-up was 12 months. Main outcome measures were the surgical result and its stability. RESULTS: A total of 22 patients were included. Mean age at the time of surgery was 41.7 ± 19.1 years (range, 4.5-69). The etiologies for the palsy were head trauma (11), tumor (10), and idiopathic (1). Mean follow-up time was 44.2 ± 37.4 months (range, 12-123). The average distance deviation was 38.1(Δ) ± 11.6(Δ) preoperatively, 4.0(Δ) ± 16.1(Δ) 3 months after the operation (p = 0.0004), and 7.9(Δ) ± 8.8(Δ) at 12 months (p = 0.0003), with no subsequent change. At the final examination, on average 44.2 months after the operation, 13 patients (59%) were within 10(Δ) of alignment, 2 (1%) were overcorrected, and 7 (32%) had vertical deviations. The majority of patients (73%) had no double vision in the primary position. No patient developed anterior segment ischemia. CONCLUSIONS: Vertical rectus muscle transposition combined with intraoperative botulinum toxin injection into the ipsilateral medial rectus muscle improved alignment in patients with complete chronic sixth nerve palsy. While the effects of treatment may have diminished slightly during the first year after surgery, they remained stable thereafter.

Multimodal registration procedure for the initial spatial alignment of a retinal video sequence to a retinal composite image.

Accurate placement of lesions is crucial for the effectiveness and safety of a retinal laser photocoagulation treatment. Computer assistance provides the capability for improvements to treatment accuracy and execution time. The idea is to use video frames acquired from a scanning digital ophthalmoscope (SDO) to compensate for retinal motion during laser treatment. This paper presents a method for the multimodal registration of the initial frame from an SDO retinal video sequence to a retinal composite image, which may contain a treatment plan. The retinal registration procedure comprises the following steps: 1) detection of vessel centerline points and identification of the optic disc; 2) prealignment of the video frame and the composite image based on optic disc parameters; and 3) iterative matching of the detected vessel centerline points in expanding matching regions. This registration algorithm was designed for the initialization of a real-time registration procedure that registers the subsequent video frames to the composite image. The algorithm demonstrated its capability to register various pairs of SDO video frames and composite images acquired from patients.

Automated bone contour detection in ultrasound B-mode images for minimally invasive registration in computer-assisted surgery-an in vitro evaluation.

BACKGROUND: Minimally invasive surgical interventions performed using computer-assisted surgery (CAS) systems require reliable registration methods for pre-operatively acquired patient anatomy representations that are compatible with the minimally invasive paradigm. The use of brightness-mode ultrasound seems to be promising, if associated devices work in a computationally efficient and fully automatic manner. METHODS: This paper presents a rapid and fully automatic segmentation approach for ultrasound B-mode images capable of detecting echoes from bony structures. The algorithm focuses on the precise and rapid detection of bone contours usable for minimally invasive registration. The article introduces the image-processing scheme and a set-up enabling a direct comparison between manually digitized reference points and the segmented bone contours. The segmentation accuracy was assessed using cadaveric material. RESULTS: The experimental evaluation revealed results in the same order of magnitude as a pointer-based surface digitization procedure. CONCLUSION: The suggested segmentation approach provides a reliable means of detecting bony surface patches in ultrasound images.

A-mode ultrasound-based registration in computer-aided surgery of the skull.

OBJECTIVE: To evaluate the integration and accuracy of A (amplitude)-mode ultrasound-based surface matching for noninvasive registration of the head into a frameless computer-aided surgery system for otorhinology and skull base surgery. DESIGN: Experimental study and case series. SETTING: Academic medical center. PATIENTS: Twelve patients underwent anterior and paranasal skull base surgery with the routine use of a computer-aided surgery system. INTERVENTIONS: A computer-aided surgery system, based on an optoelectronic localizer, was used to track the skull and the surgical tools, including the A-mode ultrasound probe. The A-mode probe was a 10-MHz immersion transducer. An acoustic lens attached to the transducer focused the ultrasonic beam to a depth of 1 to 10 mm. Accuracy tests were performed for the ultrasound setup. Different surface point distributions were evaluated with respect to matching accuracy on a human cadaver skull specimen equipped with fiducial markers. The matching comparison was based on the fiducial registration error. For the clinical evaluation, the laboratory setup was transferred to the operating room. MAIN OUTCOME MEASURES: Noninvasive registration of the skull by using A-mode ultrasound in computer-aided surgery (practical and clinical measurements). RESULTS: The accuracy tests on the human skull specimen revealed that the mean +/- SD fiducial registration error was 1.00 +/- 0.19 mm in the best series for A-mode ultrasound surface matchings and was robust with respect to different sets of surface points. The mean +/- SD root mean square error from the 12 A-mode ultrasound matchings in the patient study was 0.49 +/- 0.20 mm. CONCLUSION: A-mode ultrasound surface matching can be used as a noninvasive and accurate registration procedure in computer-aided surgery of the head.

On the development and comparative evaluation of an ultrasound B-mode probe calibration method.

OBJECTIVE: Precise transducer calibration is an essential prerequisite for reliable surface registration based on ultrasound B-mode imaging devices. The clinical usage of a novel B-mode transducer calibration technique was evaluated and its attainable calibration precision assessed. MATERIALS AND METHODS: The Three Wire Method and the Cambridge Calibration Method were used as reference techniques to compare the efficiency, calibration precision and spatial requirements of the different techniques. A total of 20 calibration trials were performed using each technique and were statistically evaluated for accuracy and speed. RESULTS: The mean error characterizing the calibration precision of the Three Wire Method was 3.2 mm, obtained in a phantom with a volume of 14 x 10(6) mm(3) in 18.48 min. The Cambridge method resulted in a mean calibration error of 2.2 mm, but required a larger phantom with a volume of 35 x 10(6) mm3 to be used for a duration of 9.30 min. The proposed method yielded an average calibration error of 1.9 mm and was performed, on average, in 2 min using a phantom with a size smaller than 1 x 10(6) mm3. CONCLUSIONS: The suggested calibration method offers decreased time and space while retaining an equivalent calibration precision when compared to established reference methods.