[The effect of reaferon and alpha-tocopherol on lipid peroxidation in experimental influenza]. / Vliianie reaferona i alpha-tokoferola na protsessy perekisnogo okisleniia lipidov pri éksperimental'noi grippoznoi infektsii.

Reaferon administered to outbred young mice with experimental influenza had a positive effect on morphologic changes in pulmonary tissues and on lipid peroxidation in the blood plasma and pulmonary tissues. Combined use of reaferon and alpha-tocopherol in mice infected with influenza A virus reduced the mortality rate, boosted the antiviral effect of reaferon proper, and led to virtually complete normalization of lipid peroxidation processes in the blood plasma and pulmonary tissues.

[The systemic disorder of connective tissue metabolism and hypoplasia of the nephron elements in hereditary nephritis in children]. / Sistemnoe narushenie metabolizma soedinitel'noi tkani i gipoplaziia élementov nefrona pri nasledstvennom nefrite u detei.

Clinical biochemistry and morphological methods were employed to examine 25 children aged 3 to 15 years with hereditary nephritis. Measurements were made of morphological alterations in renal biopsy specimens, excretion with urine of connective tissue metabolites (hydroxyproline, hydroxylysine glycosides, glycosaminoglycans), the level of the same metabolites and characteristic features of the cellular growth of skin fibroblasts in culture. The early stages of nephritis development were marked by hypoplasia of nephron elements, followed by dystrophy and destruction of its ultrastructural elements including collagen of the glomerular basal membranes. The status of the skin fibroblast cell culture corresponded with the changes seen in renal cells of mesenchymal origin. The conclusion is made that in children with hereditary nephritis, nephron cells and skin fibroblasts reflect systemic metabolic defect of the connective tissue.

[Characteristics of higher nervous activity in young children, cholesterol metabolism and state of the adrenal cortex]. / Osobennosti vysshei nervnoi deiatel'nosti u detei rannego vozrasta, obmen kholesterina i sostoianiia kory nadpochechnikov.

The relationship was established between cholesterol metabolism, adrenocortical function and the typological features of the higher nervous activity in children. Cholesterol metabolism was found to correlate with the type of the higher nervous activity. The children with deficient force and mobility of the nervous processes showed a decrease of glucocorticoid function of the adrenal cortex, proneness to an elevation of the cholesterol level in blood serum and delay of its excretion with feces. This dictates the necessity of developing special diets for the group of children under consideration.

[State of lipid peroxidation system and antioxidant defense in acute respiratory viral infection in children and the principles of pathogenetic therapy]. / Sostaianie sistemy perekisnoe okislenie lipidov--antioksidantnaia zashchita pri ostroi respiratornoi virusnoi infektsii u detei i printsipy patogeneticheskoi terapii.

Summary. Altogether 187 young children presenting with acute respiratory viral infection were examined for lipid peroxidation and antioxidant defense. The principles of the pathogenetically validated antioxidant treatment are discussed.

[Lipid peroxidation in experimental viral infection and the effect on it of interferons and alpha-tocopherol]. / Protsessy perekisnogo okisleniia lipidov pri éksperimental'noi virusnoi infektsii i vliianie na nikh interferonov i alpha-tokoferola.

Lipid peroxidation as well as effects of various interferons (native, from fibroblasts of new born and adult animals) on the peroxidation were studied in blood plasma, erythrocytes, liver and kidney tissues of mice with viral infection. These interferons, simultaneously with antiviral action, exhibited the positive effect on lipid peroxidation, while the interferon from fibroblasts of newborns produced the side reactions. Simultaneous use of the interferon and alpha-tocopherol removed these side reactions.

[Hydroxyproline and acid glycosaminoglycans in acute cerebral circulatory disorders]. / Oksiprolin i kislye glikozaminoglikany pri ostrykh narusheniiakh mozgovogo krovoobrashcheniia.

In patients with acute disorders of cerebral circulation dynamic examinations of hydroxyproline excretion, total content of glycosamineglycans (GAGs) and content of the latters' fractions were carried out. During the first week of the disease the total content of the GAGs in the urine daily portion was found to be increased, this increase being statistically significant and correlating with the size of the expected brain lesion. The fractional spectrum of the GAGs changed towards greater content of sulphonated fractions. By the 3d--5th week of the disease the hydroxyproline concentration in the urine sharply rose, an evidence of the intense organizational processes within the ischemic focus by that time.