Quantitative characterization of higher-order mode converters in weakly multimoded fibers.

We present a rigorous analysis methodology of fundamental to higher order mode converters in step index few mode optical fibers. We demonstrate experimental conversion from a fundamental LP01 mode to the higher order LP11 mode utilizing a multiple mechanical bend mode converter. We perform a quantitative analysis of the measured light intensity, and demonstrate a modal decomposition algorithm to characterize the modal content excited in the fiber. Theoretical modelling of the current mode converter is then performed and compared with experimental findings.

Transmission of images through highly nonlinear media by gradient-index lenses formed by incoherent solitons.

We experimentally demonstrate image transmission through a noninstantaneous self-focusing medium. A partially spatially incoherent soliton is used to form a multimode waveguide in a photorefractive crystal, and the modes of that waveguide are used to transmit an incoherent image through this nonlinear medium.

Self-trapping of bright rings.

We present experimental observations of self-trapped rings carrying zero topological charge, along with simulations that display the self-focusing dynamics of the rings and their stability features in materials with saturable nonlinearities.

Information transfer via cascaded collisions of vector solitons.

We demonstrate experimentally the transport of information from one vector (Manakov-like) spatial soliton to another via collisions with a third, intermediate soliton.

Eliminating the transverse instabilities of kerr solitons

We show analytically, numerically, and experimentally that a transversely stable one-dimensional [(1+1)D] bright Kerr soliton can exist in a 3D bulk medium. The transverse instability of the soliton is completely eliminated if it is made sufficiently incoherent along the transverse dimension. We derive a criterion for the threshold of transverse instability that links the nonlinearity to the largest transverse correlation distance for which the 1D soliton is stable.

Observation of two-dimensional multimode solitons.

We present the first experimental observation of (2+1) -dimensional multimode (composite) solitons. A single-hump component and a double-hump (dipole-type) component are jointly self-trapped as a composite soliton in a biased photorefractive crystal.

Second-harmonic generation in waveguides induced by photorefractive spatial solitons.

We demonstrate experimentally second-harmonic generation in waveguides induced by photorefractive solitons and show that the conversion efficiency is improved considerably. These induced waveguides are flexible and can be generated in any crystalline direction that allows soliton formation, and thus offer broad tunability (by rotation of the crystal), which cannot exist in fabricated waveguides.

Optically induced photovoltaic self-defocusing-to-self-focusing transition.

We show theoretically and experimentally that the photovoltaic nonlinearity that gives rise to spatial solitons can be switched from self-defocusing to self-focusing (or vice versa) by use of background illumination. This raises the possibility of bright photovoltaic solitons in LiNbO(3) .

Codon 12 ras mutations in patients with myelodysplastic syndrome: incidence and prognostic value.

To determine the prevalence of activated rasoncogenes (N-ras, Harvey-ras Kirsten-ras), DNA derived from peripheral blood of 51 patients with myelodysplastic syndrome (MDS) was investigated. The method was based on the polymerase chain reaction (PCR) technique to amplify DNA, followed by restriction fragment length polymorphism (RFLP) analysis. Among the French-American-British (FAB) subtypes, N-ras mutations were found in two patients with refractory anemia with excess of blasts (RAEB), in one patient with refractory anemia with excess of blasts in transformation (RAEB-t), and in two patients with chronic myelomonocytic leukemia (CMML). MDS patients with a mutation at codon 12 of the N-ras gene showed shorter survival duration than other MDS patients of the same FAB subtypes, although these findings proved to be not statistically significant (P > 0.1). Interestingly, all but one patient with N-ras mutation developed acute myelogenous leukemia (AML). In conclusion, the presence of mutation at codon 12 of the N-ras gene might serve as a negative prognostic factor at diagnosis of MDS.

Myelodysplastic syndromes: analysis of 131 cases according to the FAB classification.

The clinical and haematological findings in 131 patients with myelodysplastic syndromes (MDS), none of which had previously received chemotherapy or radiotherapy, classified according to the FAB criteria, were analysed. The distribution among the 5 subgroups was: RA 31 patients, RAS 19, RAEB 23, CMML 29 and RAEBT 29 patients. There were difficulties in the classification of 24 patients. These included, first, 8 cases with myeloid hyperplasia of the bone marrow (BM) but without monocytosis or excess of blasts of the BM. They were classified as RA. Second, 8 cases with sideroblastosis but with monocytosis or excess of blasts of the BM were classified 3 as RAEB, 2 as CMML and 3 as RAEBT. Finally, 8 cases with absolute monocytosis and BM blasts 15-30% were classified as CMML. 37 of 82 dead patients (45.1%) had transformed to acute non-lymphoblastic leukaemia (ANLL). The incidence of evolution to ANLL was low for RA and RAS (6.30% and 12.5% respectively), while it was 37.5% for RAEB, 57.1% for CMML and 77.2% for RAEBT. The median survival for each subgroup was: RA 18 months; RAS 25; RAEB 13; CMML 14 and RAEBT 10 months. It is concluded that the FAB classification with some modifications recognises group of MDS with different prognosis.