RESUMO
The purpose of this study was to assess the cognitive development of 27 children with nonhemorrhagic neonatal stroke (occurring within the first 28 days of life). The cognitive evaluation consisted of the Bayley Scales of Infant Development, administered at 12 and/or 24 months poststroke. Compared with the normative sample, children with neonatal stroke obtained significantly lower scores on the Bayley Psychomotor Development Index at 12 months poststroke and on the Bayley Mental and Psychomotor Development Indices at 24 months poststroke. Outcome did not differ based on stroke type or laterality of infarct. However, there was a trend toward higher scores on the Bayley Psychomotor Development Index at 24 months in the left hemisphere group compared to the right hemisphere group. Overall, children with neonatal stroke evidenced significant impairment within the first 2 years poststroke. Further research is required to confirm whether cognitive impairments in these children resolve, remain in the low-average range, or increase with development as more complex skills are learned.
Assuntos
Transtornos Cognitivos/fisiopatologia , Transtornos Cognitivos/psicologia , Deficiências do Desenvolvimento/fisiopatologia , Deficiências do Desenvolvimento/psicologia , Acidente Vascular Cerebral/fisiopatologia , Acidente Vascular Cerebral/psicologia , Infarto Cerebral/complicações , Infarto Cerebral/fisiopatologia , Infarto Cerebral/psicologia , Pré-Escolar , Transtornos Cognitivos/etiologia , Deficiências do Desenvolvimento/etiologia , Avaliação da Deficiência , Feminino , Lateralidade Funcional , Humanos , Lactente , Recém-Nascido , Masculino , Testes Neuropsicológicos , Transtornos Psicomotores/etiologia , Transtornos Psicomotores/fisiopatologia , Transtornos Psicomotores/psicologia , Fatores Sexuais , Acidente Vascular Cerebral/complicações , Tempo , Fatores de TempoRESUMO
Little is known about the cognitive sequelae of pediatric-onset multiple sclerosis (MS). Ten pediatric patients with MS were evaluated using a comprehensive neuropsychological battery. Neuropsychological deficits were identified on measures of general cognition, language, visuomotor integration, and verbal and visual memory. Cognitive impairment occurs in children with MS, and those with longer disease duration and younger age at MS onset appear to be at greatest risk.
