Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Children (Basel) ; 9(4)2022 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-35455523

RESUMO

Clinical pharmacy services (CPS) have shown beneficial effects on several outcome measures in hospital patients, including the reduction of drug-related problems (DRP) and of therapy costs. Less is known about the impact of CPS in pediatric haemato-oncology, even though this patient population is highly susceptible to DRP. CPS were implemented in a tertiary care children's hospital specialized in hemato-oncology and hematopoietic stem cell transplantation. The main outcome measures were type and number of DRP, type and number of pharmaceutical interventions (PI), their acceptance rate, and their clinical significance and economic benefit. During 6 months and 32 ward rounds, 275 DRP were identified and addressed by PI. The acceptance of PI was high (73.4%), and up to 80% of PI were rated as very significant or significant by independent external raters. The estimated therapy cost reductions were substantial, approaching at least EUR 54,600 for avoided follow-up costs. Conclusion: CPS improve medication safety in pediatric hemato-oncology and may reduce therapy costs.

2.
Wien Med Wochenschr ; 160(9-10): 235-46, 2010 May.
Artigo em Alemão | MEDLINE | ID: mdl-20632152

RESUMO

Due to complex physical and psychological changes in aging, pain measurement and therapeutic treatment of older and geriatric patients present a special challenge. Nevertheless, even for this category of patients, good treatment results are achievable if age-related particulars and problems are consistently heeded and accounted for. That includes adverse sensory and cognitive effects as much as multimorbidity and the polypharmacy that is frequently related to it. An essential prerequisite for adequate pain therapeutic care in elderly patients is consistent pain measurement. While numerical and verbal scales have also proven their usefulness for patients in advanced age who are not cognitively impaired, instruments must be applied for older people with communicative and/or cognitive restrictions with which the observed behavior of those involved can be surveyed in a multidimensional way.


Assuntos
Analgésicos/uso terapêutico , Medição da Dor/métodos , Dor/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Analgésicos/efeitos adversos , Doença Crônica , Transtornos Cognitivos/psicologia , Comorbidade , Avaliação da Deficiência , Interações Medicamentosas , Humanos , Comunicação não Verbal , Dor/etiologia , Dor/psicologia , Medição da Dor/psicologia , Papel do Doente
3.
Neuropsychiatr ; 22(3): 153-71, 2008.
Artigo em Alemão | MEDLINE | ID: mdl-18826870

RESUMO

Cholinesterase inhibitors and memantine can slow the course of Alzheimer's disease. In Austria the frequency of treatment is in the upper third among countries of the EU. Yet, the majority of Alzheimer patients does not receive adequate medication. Compliance to treatment is low. Studies on cholinesterase inhibitors show that only one third and one fifth of patients adhere to medication after 3 months and 12 months, respectively. Causes for low compliance are only partly patient-related, many factors are system-inherent. Knowledge of these factors is a pre-requisite for the treating physician to improve current unfavourable situation. Present treatment strategies are symptomatic, causal disease-modifying therapies are urgently needed. Research activity in the field is high and dominated by the amyloid hypothesis. We here review the basis and recent studies on secretase-inhibitors, immunization, aggregation of Abeta, statins and PPARgamma-agonists. Research towards strategies against tau-pathology is less dominant and focuses on inhibition of kinases and increase of activity of phosphatases. Causal therapies would have great effects on a population basis even if efficacy is only moderate. A disease-modifying therapy which delays the onset of Alzheimer disease by 5 years, will probably reduce the number of patients by nearly 50% during the next 50 years.


Assuntos
Doença de Alzheimer/tratamento farmacológico , Inibidores da Colinesterase/uso terapêutico , Memantina/uso terapêutico , Nootrópicos/uso terapêutico , Doença de Alzheimer/diagnóstico , Doença de Alzheimer/etiologia , Vacinas contra Alzheimer/uso terapêutico , Secretases da Proteína Precursora do Amiloide/antagonistas & inibidores , Peptídeos beta-Amiloides/imunologia , Peptídeos beta-Amiloides/metabolismo , Animais , Encéfalo/efeitos dos fármacos , Inibidores da Colinesterase/efeitos adversos , Contraindicações , Interações Medicamentosas , Uso de Medicamentos/estatística & dados numéricos , Drogas em Investigação/efeitos adversos , Drogas em Investigação/uso terapêutico , Humanos , Imunoterapia , Memantina/efeitos adversos , Emaranhados Neurofibrilares/efeitos dos fármacos , Nootrópicos/efeitos adversos , Cooperação do Paciente/estatística & dados numéricos , Placa Amiloide/efeitos dos fármacos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...