RESUMO
Markedly unequal distribution of hepatitis C virus (HCV) among blood donors in different regions of the USSR was established. The necessity of introduction into the blood service of regular donor blood screening for anti-C100-3 is substantiated. The portion of chronic hepatitis associated with HCV in the structure of chronic virus hepatitis was established. The results of the study indicate the expedience of specific virus hepatitis C prophylaxis in contingents of high risk of HCV infection.
Assuntos
Hepacivirus/imunologia , Anticorpos Anti-Hepatite/sangue , Hepatite C/epidemiologia , Doadores de Sangue , Hemofilia A/imunologia , Anticorpos Anti-Hepatite B/sangue , Antígenos do Núcleo do Vírus da Hepatite B/imunologia , Antígenos de Superfície da Hepatite B/sangue , Hepatite C/imunologia , Anticorpos Anti-Hepatite C , Hepatite Crônica/imunologia , Humanos , Incidência , Falência Renal Crônica/imunologia , Fatores de Risco , U.R.S.S./epidemiologia , População Urbana/estatística & dados numéricosAssuntos
Frutose-Bifosfato Aldolase/sangue , Hepatite B/enzimologia , Isoenzimas/sangue , L-Lactato Desidrogenase/sangue , Malato Desidrogenase/sangue , Tuberculose Pulmonar/complicações , Adolescente , Adulto , Feminino , Hepatite B/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Tuberculose Pulmonar/enzimologiaRESUMO
The activity of lactate dehydrogenase (LDH) and its isoenzymes was studied in various biological media in 850 patients with viral hepatitides (VH). The activity of LDH and its isoenzyme LDH5 in the blood serum, formed elements and in the urine of VH patients changed more noticeably in a grave form of disease and in antigen positive VH. A sharp rise of LDH and LDH5 activity in the blood serum of patients with a severe form of VH with its subsequent considerable decrease was indicative of the development of acute liver necrosis. Changes in the activity of LDH and its isoenzymes in the formed blood elements of VH patients pointed out to disturbance in the energetic system influencing their morphological and functional condition. Shifts of LDH and its isoenzymes in the urine of patients indicated renal lesion which could be used for the detection of latent disorders of renal function in VH. A study of the activity of LDH and its isoenzymes in the blood formed elements and in the urine of VH patients was of certain diagnostic value but inferior in many respects to its determination in the blood serum.
