RESUMO
The experiment on 120 non-inbred albino rats with induced pulmonary destructive tuberculosis has established that the antiinflammatory action of the antioxidant dibunol is displayed through changes in the ratio of biologically active 11-hydroxycorticosteroids--free hydrocortisone and corticosterone.
Assuntos
Hidroxitolueno Butilado/uso terapêutico , Isoniazida/uso terapêutico , Tuberculose Pulmonar/tratamento farmacológico , 11-Hidroxicorticosteroides/sangue , Animais , Hidroxitolueno Butilado/farmacologia , Quimioterapia Combinada , Isoniazida/farmacologia , Peroxidação de Lipídeos/efeitos dos fármacos , Malondialdeído/sangue , Modelos Biológicos , Ratos , Tuberculose Pulmonar/sangue , Tuberculose Pulmonar/patologiaAssuntos
Doenças dos Genitais Femininos/diagnóstico , Teste Tuberculínico , Tuberculose dos Genitais Femininos/diagnóstico , Temperatura Corporal/efeitos dos fármacos , Feminino , Doenças dos Genitais Femininos/metabolismo , Humanos , Injeções Subcutâneas , Peroxidação de Lipídeos/efeitos dos fármacos , Malondialdeído/sangue , Tuberculina/administração & dosagem , Tuberculose dos Genitais Femininos/metabolismoRESUMO
The results of endobronchial treatment of 9 patients with post-tuberculous fibrous stenoses of large bronchi by using neodymium-YAG laser are presented. After recanalization of fibrous stenoses the patients were given antioxidants (7.5% sodium thiosulfate solution, 0.5 ml, as endobronchial infusions in combination with oral or intramuscular alpha-tocopherol, 600 mg, for a month) in combination with endobronchial phototherapy with helium-neon laser radiation. This therapy improved the patients' general condition, pulmonary functional parameters, normalized lipid peroxidation and enhanced epithelial regeneration in the bronchial mucosa, thus providing a steady-state dilatation of the airways lumen by more than twice than that in stenosis.
Assuntos
Brônquios/cirurgia , Terapia a Laser , Fibrose Pulmonar/cirurgia , Tuberculose Pulmonar/complicações , Brônquios/patologia , Líquido da Lavagem Broncoalveolar/metabolismo , Humanos , Peroxidação de Lipídeos , Fibrose Pulmonar/etiologia , Fibrose Pulmonar/metabolismoRESUMO
Sarcoidosis ran a favourable course in 166 out of 179 patients. The active phase of sarcoidosis was characterized by dysproteinemia, high content of histamine, STH and beta-lipoproteins together with a decrease of HPI and total protein. More remarkable shifts were observed in patients afflicted with sarcoidosis of the intrathoracic lymph nodes and of the lungs. In the phase of regression, there was a unidirectional change in the majority of the parameters, which correlated with the process liability to the reverse development. It may be recommended that the content of histamine, HPI and beta-lipoproteins should be measured along with other parameters to estimate the process activity in patients with respiratory sarcoidosis.
Assuntos
Pneumopatias/sangue , Sarcoidose/sangue , Adolescente , Adulto , Idoso , Quimioterapia Combinada , Feminino , Humanos , Pneumopatias/tratamento farmacológico , Doenças Linfáticas/sangue , Doenças Linfáticas/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Indução de Remissão , Remissão Espontânea , Sarcoidose/tratamento farmacológicoRESUMO
As a result of experimental research on rats with destructive pulmonary tuberculosis, oxidative action of isoniazid in a dose of 50 mg per kg body weight, corresponding to the mean therapeutic dose of 10 mg/kg in man, was clearly defined. Fibrotic action of the drug was also shown. It manifested itself by a sharp rise of insoluble collagen levels in the lung tissue tuberculous lesion focus of the treated animals and in the formation of mature connective tissue. Two mechanisms of isoniazid's pro-fibrotic action are presented.
Assuntos
Isoniazida/uso terapêutico , Peroxidação de Lipídeos/efeitos dos fármacos , Fibrose Pulmonar/induzido quimicamente , Tuberculose Pulmonar/tratamento farmacológico , Animais , Isoniazida/toxicidade , RatosRESUMO
Characteristic features of pulmonary lesions after exposure to paraquat and various antioxidants were studied in albino rats. The antioxidants included dibunol, sodium thiosulfate and its combination with alpha-tocoferol. In the treated animals, there was a marked decrease in the areas affected by atelectasis and lower severity of elastofibrosis, involution of the connective tissue evident from its thinner fascicles and destruction of the collagenous and elastic fibers.
Assuntos
Antioxidantes/uso terapêutico , Pulmão/efeitos dos fármacos , Paraquat/toxicidade , Animais , Modelos Animais de Doenças , Avaliação Pré-Clínica de Medicamentos , Pulmão/patologia , Atelectasia Pulmonar/induzido quimicamente , Atelectasia Pulmonar/tratamento farmacológico , Atelectasia Pulmonar/patologia , Fibrose Pulmonar/induzido quimicamente , Fibrose Pulmonar/tratamento farmacológico , Fibrose Pulmonar/patologia , Ratos , Ratos Endogâmicos , Tuberculose Pulmonar/tratamento farmacológico , Tuberculose Pulmonar/etiologia , Tuberculose Pulmonar/patologiaAssuntos
Antioxidantes/uso terapêutico , Hialuronoglucosaminidase/uso terapêutico , Tuberculose Pulmonar/tratamento farmacológico , Animais , Antituberculosos/uso terapêutico , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Quimioterapia Combinada , Humanos , Ratos , Fatores de TempoAssuntos
Sarcoidose/sangue , Adolescente , Adulto , Idoso , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Antioxidantes/uso terapêutico , Antituberculosos/efeitos adversos , Hipersensibilidade a Drogas/prevenção & controle , Tuberculose Pulmonar/tratamento farmacológico , Avaliação de Medicamentos , Hipersensibilidade a Drogas/etiologia , Quimioterapia Combinada , Humanos , Tiossulfatos/uso terapêutico , Tuberculose Pulmonar/sangue , Vitamina E/sangue , Vitamina E/uso terapêuticoAssuntos
Eletronarcose , Tuberculose Pulmonar/cirurgia , Equilíbrio Ácido-Base , Adolescente , Adulto , Coagulação Sanguínea , Gasometria , Hemodinâmica , Humanos , Período Intraoperatório , Pessoa de Meia-Idade , Neuroleptanalgesia , Pneumonectomia , Período Pós-Operatório , Medicação Pré-Anestésica , Tuberculose Pulmonar/sangueAssuntos
Antioxidantes/uso terapêutico , Hidroxitolueno Butilado/uso terapêutico , Tiossulfatos/uso terapêutico , Tuberculose Pulmonar/tratamento farmacológico , Animais , Feminino , Peróxidos Lipídicos/antagonistas & inibidores , Peróxidos Lipídicos/metabolismo , Pulmão/metabolismo , Masculino , RatosRESUMO
The effect of an antioxidant, sodium thiosulphate (in doses of 100 and 150 mg/kg), on morphological manifestations of experimental tuberculosis was studied in 35 white rats. Sodium thiosulphate exerted a marked antiinflammatory and antisclerogenic effect. Changes in morphology (rearrangement of fibrous connective tissue into loose shapeless tissue with increased number of cell elements, mainly lymphocytes, and changes in the structure of collagen fibers down to granular degeneration) and typical properties of the connective tissues (decreased fuxinophilia, decreased content of proteoglycans and glycoproteins, appearance of picrinophilia) were observed in different periods of tuberculosis development which led to a conclusion that sodium thiosulphate not only partially prevented the crude fibrosis formation but also affected the already formed fibrous tissue by its resorption.