RESUMO
Appendage tumors of the pilosebaceous apparatus are relatively rare, and their clinical aspect is usually nonspecific. In most cases pilosebaceous tumors are benign; however, malignant neoplasias (e.g. trichilemmal carcinoma, malignant pilomatricoma) have been described. In the present review we propose the classification of pilosebaceous tumors by degree and by direction of differentiation and by histological configuration. Three different histological patterns have to be distinguished: tumors with central dilated hair follicle, tumors consisting of epithelial islands and keratotic cysts in the corium and neoplasias with predominantly mesenchymal components surrounding epithelial formations. Careful histopathological examination of pilar appendage tumors will help to classify the wide range of clinically and histologically different tumors and to establish the exact diagnosis.
Assuntos
Neoplasias das Glândulas Sebáceas/patologia , Humanos , Neoplasias das Glândulas Sebáceas/classificação , Neoplasias das Glândulas Sebáceas/diagnósticoRESUMO
One hundred malignant pleural mesotheliomas have been treated in our hospital since 1955. Clinical and autopsy findings are analyzed and compared to X-ray changes. The most common symptoms were dyspnea (49%), pain (40%) and cough (36%). The main initial X-ray signs were pleural effusion (62%), pleural thickening (29%) and solitary nodules (6%). Prior to death a combination of effusion and pleural thickening was the usual finding. Histologically there were 49 biphasic, 32 mesenchymal and 18 epithelial malignant pleural mesotheliomas. At autopsy 82% of the cases had distant metastases, most of which had not been expected clinically. The median survival time was 7.3 months following the first clinical symptoms, and only 4 months after the first radiological signs.
Assuntos
Mesotelioma/fisiopatologia , Neoplasias Pleurais/fisiopatologia , Adulto , Idoso , Biópsia , Feminino , Seguimentos , Humanos , Masculino , Mesotelioma/diagnóstico , Mesotelioma/diagnóstico por imagem , Mesotelioma/patologia , Pessoa de Meia-Idade , Cuidados Paliativos , Neoplasias Pleurais/diagnóstico , Neoplasias Pleurais/diagnóstico por imagem , Neoplasias Pleurais/patologia , Prognóstico , Radiografia TorácicaRESUMO
In 100 pleural mesotheliomas follow up x-ray studies were compared to autopsy findings. Initially x-ray examinations show effusions in 62%, diffuse pleural thickening in 29% and solitary pleural nodules in 6%, prior to death effusions and pleural thickening are usually combined. In 17 tumor nodules doubling times ranged from 0.5 to 3 months. The epithelial type of mesotheliomas is predominantly combined with pleural effusions, while pleural thickening is more often found in the mesenchymal type of the tumor.
