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3.
Int. braz. j. urol ; 44(4): 765-770, July-Aug. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-954087

RESUMO

ABSTRACT Introduction: The urinary bladder diverticula (BD) secondary to benign prostatic hyperplasia (BPH) is a complication that can lead to urinary stasis, stone, urinary tract infection (UTI) and tumors. It's role in acute urinary retention (AUR) is not totally understood. Objectives: To determine the effect of BD size on AUR rates in patients with BPH candidates to surgery. Subjects and Methods: We performed a retrospective cohort study of 47 patients with BPH and BD who underwent BPH surgery associated to complete bladder diverticulectomy from 2006 to 2016. We analyzed risk factors for AUR in patients with BD using univariate, multivariate and correlation analysis. Results: There was a difference in the size of the diverticula, with 6.8 cm vs. 4.5 cm among patients with and without AUR respectively (p=0.005). The ROC curve showed a correlation between the size of BD and the risk of AUR. The value of 5.15 cm presented a sensitivity of 73% and a specificity of 72%. The area under the curve was 0.75 (p=0.01). Comparing groups with BD >5.0 cm vs. ≤5.0 cm, the AUR incidence was 74% and 27.8% respectively with an OR of 2.65 (1.20-5.85) (p=0.005). In the multivariate analysis, only the size of the diverticula reached statistical significance (p=0.012). Conclusions: The diameter of BD is an independent risk factor for AUR in patients with BPH and BD who are candidates to surgery. A diameter greater than 5.15 cm increases the risk of AUR.


Assuntos
Humanos , Masculino , Idoso , Hiperplasia Prostática/cirurgia , Hiperplasia Prostática/complicações , Bexiga Urinária/anormalidades , Retenção Urinária/etiologia , Divertículo/complicações , Divertículo/patologia , Valores de Referência , Bexiga Urinária/patologia , Bexiga Urinária/diagnóstico por imagem , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios X , Doença Aguda , Estudos Retrospectivos , Fatores de Risco , Curva ROC , Divertículo/diagnóstico por imagem , Medição de Risco , Pessoa de Meia-Idade
4.
Environ Toxicol Pharmacol ; 19(1): 169-75, 2005 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21783473

RESUMO

The effects of oral exposure to methylmercury chloride (MeHg) on locomotor control and activity in adult mice were investigated in the present study. MeHg was diluted in drinking water (0, 20 and 40mg/L - as methylmercury chloride) and locomotion (spontaneous locomotor activity) and motor impairment tests (beam walking, footprint and clasping) were performed at 7, 14 and 21 days after the beginning of the treatment. MeHg exposure caused a significant decrease in spontaneous locomotor activity and this effect was dose- and time-dependent. Significant dose- and duration-dependent increases in beam walking latency were observed following chronic MeHg exposure. Furthermore, dose- and duration-dependent locomotor deficits on footprint coordination were also observed. Taken together, these results show that MeHg-induced impairment on locomotor activity is not limited to exposures that take place during neural development. We discuss the possible relationship between our findings and the similar clinical signs observed in adult humans exposed to MeHg.

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