1.
Mol Biosyst
; 9(6): 1286-9, 2013 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23567908
RESUMO
The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2-3, respectively.