RESUMO
A study of the pituitary gonadal axis was undertaken in 18 male patinets with thalassemia major and 41 normal males, in order to define the cause of the sexual infantilism frequently seen in children affected by this illness. The plasma testosterone level was measured before as well as after stimulatioing prepubertal, pubertal and postpubertal age. Significant findings were an insufficient secretion of gonadotropins as well as low testosterone level in patients of pubertal and post-pubertal age. A normal response of testes to HCG stimulation was also observed.
Assuntos
Hormônio Foliculoestimulante/metabolismo , Hormônio Luteinizante/metabolismo , Sistema Hipófise-Suprarrenal/fisiopatologia , Testículo/metabolismo , Testosterona/metabolismo , Talassemia/fisiopatologia , Adolescente , Adulto , Criança , Pré-Escolar , Gonadotropina Coriônica , Hormônio Foliculoestimulante/sangue , Humanos , Hormônio Luteinizante/sangue , Masculino , Puberdade , Testosterona/sangueRESUMO
The study of calcium metabolism in ten thalassaemic children comperatively with controls after oral administration of 47Ca has shown diminished intestinal absorption. It is suggested that this finding is propably related in part with the pathogenesis of the osteoporosis in thalassaemia.
Assuntos
Cálcio/metabolismo , Talassemia/metabolismo , Criança , Pré-Escolar , Feminino , Humanos , Absorção Intestinal , Masculino , Osteoporose/etiologia , Talassemia/complicaçõesRESUMO
The administration of 2 mg/kg body weight of prednisolone daily in divided doses to 5 healthy children aged 5-7 years resulted in a significant decrease in the amount of total urinary hydroxyproline (HOP) which was restored to pretreatment levels two weeks after discontinuation of the drug. On the other hand, the administration of 2 mg/kg body weight of prednisolone in a single dose on alternate days (every-other-day) to two children and for a period of 10 days caused insignificant alterations in the amount of urinary HOP.
Assuntos
Hidroxiprolina/urina , Prednisolona/farmacologia , Criança , Pré-Escolar , Relação Dose-Resposta a Droga , Humanos , Prednisolona/administração & dosagem , Fatores de TempoRESUMO
Measurements of plasma cortisol values before and at 4 and 6 hours after intramuscular administration of a depot preparation of synthetic b1-24 corticotrophin were carried out in 12 healthy children (group B) before, as well as on the 5th day of continuous ascorbic acid (AA) administration (1 g t.i.d. orally). Comparison of the results in group B with those of 8 healthy children similarly treated with corticotrophin but not given AA (group A) showed that, on the 5th day of AA administration the mean cortisol values after ACTH were significantly lower than the corresponding values in group A (p less than 0.02), or the post-ACTH values in group B observed on the 1st experimental day, i.e., before AA administration (p less than 0.001). On the other hand, AA administration had no significant effect on the fasting plasma cortisol values. These data suggest that AA excess following adrenal stimulation with ACTH exerts an inhibitory effect on cortisol secretion and consequently it may be of no benefit in conditions of stress.
