Primary cutaneous T-cell lymphoproliferative disorder of donor origin after allogeneic haematopoietic stem-cell transplantation.

A 56-year-old male patient had a history of mantle-cell lymphoma, which was treated with polychemotherapy and reduced-intensity conditioning allogeneic haematopoietic stem cell transplantation (ASCT) from his healthy sister with an identical human leucocyte antigen profile. Six years after transplantation, the patient developed asymptomatic eczema-like cutaneous lesions. Histologically the lesions contained a dense superficial lichenoid infiltrate, mainly consisting of CD4+ atypical medium to large lymphocytes showing indented hyperchromatic nuclei. In situ hybridization for Epstein-Barr virus was negative. PCR amplification of the T-cell receptor-gamma chain gene from several lesions revealed a monoclonal rearrangement without clonal variation. Two-colour fluorescence in situ hybridization (X and Y chromosomes) and microsatellite genotyping were used to compare samples from the patient (transplant recipient), his sister (donor) and the skin biopsy sample, which confirmed that the origin of the neoplastic cells was the donor graft. To our knowledge, this is the first case of post-transplant primary cutaneous T-cell lymphoproliferative disorder after ASCT.

[Non-pulsatile aneurysm of the superficial temporal artery: a report of a case]. / Aneurisma no pulsátil de la arteria temporal superficial: a propósito de un caso.

Aneurysms of the superficial temporal artery are an uncommon cause for preauricular or parotid masses. Trauma is the most frequent etiology for a pseudoaneurysm and atheromatosis for the true aneurysm. The diagnosis is clinical due to their vascular signs (pulsatile mass, thrill...), these signs care not present when the aneurysmnas thrombosed, being this an unusual event that will make difficult a proper diagnosis. Radiological investigations are needed and helpful under these circumstances. Surgery is curative and recommended, being the excision after proximal and distal ligation of the artery the most accepted procedure. Aneurysms of the superficial temporal artery are rarely reported in the literature. We report a case that showed up as a non-pulsatile preauricular mass to highlight this unusual condition.

Aneurisma no pulsátil de la arteria temporal superficial: a propósito de un caso / Non-pulsatile aneurysm of the superficial temporal artery. A case report

Los aneurismas de la arteria temporal superficial son una causa pocofrecuente de tumoración de region preauricular o parotídea. La causa más frecuente es traumática cuando es pseudoaneurisma y arteriosclerosis-ateromatosis cuando éste es verdadero aneurisma. Su diagnóstico es clínico en base a sus características vasculares (masa pulsátil depresible, thrill...), ausentes cuando está trombosado, eventualidad infrecuente que puede complicar por ello el diagnóstico. En este caso toman importancia y son de gran ayuda las pruebas radiológicas. La cirugía escurativa y recomendable, especialmente en casos trombosados, siendo la exéresis previa ligadura proximal y distal del vaso, bien bajo anestesia local o general, la técnica más aceptada. Los aneurismas de la arteria temporal superficial son muy poco frecuentes en la literatura otorrinolaringológica. Comunicamos un caso que se presentó como una masa no pulsátil preauricular para llamar la atención acerca de esta rara lesión (AU)

Aneurysms of the superficial temporal artery are an uncommon cause for preauricular or parotid masses. Trauma is the most frequent etiology for a pseudoaneurysm and atheromatosis for the true aneurysm. The diagnosis is clinical due to their vascular signs (pulsatile mass, thrill...), these signs care not present when the aneurysmnas thrombosed, being this an unusual event that will make difficult a proper diagnosis. Radiological investigations are needed and helpful under these circumstances. Surgery is curative and recommended, being the excision after proximal and distal ligation of the artery the most accepted procedure. Aneurysms of the superficial temporal artery are rarely reported in the literature. We report a case that showed up as a non-pulsatile preauricular mass to highlight this unusual condition (AU)

Adenoma ovárico de células de Leydig: una rara causa devirilización asociada a factores de riesgo cardiovascular / Leydig cell ovarian adenoma: a rare cause of virilization associated with cardiovascular risk factors

La masculinización de la mujer adulta ovirilismo es un trastorno endocrino infrecuente debido a un exceso de secreción androgénica causado por tumores adrenales u ováricos 1. Dentro de estos últimos, los más comunes son los de células de Sertoli-Leydig (androblastomas), si bien otros tipos patológicos, como los tumores de la granulosa-teca, de células hiliares, de células lipoideas y de restos adrenales, también pueden generar el cuadro1. Presentamos un caso clínico de virilización debido a un adenoma de células de Leydig, un tumor ovárico raro que sólo representa un 0,1% de los tumores ováricos. Describimos su asociación con factores de riesgo cardiovascular y el efecto de la corrección permanente del hiperandrogenismo sobre los mismos (AU)

Carcinoma micropapilar de vejiga: presentación de un caso y revisión de la literatura / Micropapillary bladder carcinoma: A case report and a review of the literature

El carcinoma micropapilar de vejiga se define como una variedad de carcinoma transicional con un aspecto histológico similar al carcinoma seroso papilar de ovario y a carcinomas micropapilares de otras localizaciones. Su pronóstico es peor que el del carcinoma urotelial convencional, al mostrar un comportamiento más agresivo y frecuentemente un estadio más avanzado en el momento del diagnostico. Presentamos el caso de un varón de 82 años que fue intervenido de litiasis vesical y adenomectomía suprapúbica. En el momento de la intervención se identificó una lesión polipoidea sésil de 2,5 cm de eje mayor. Microscópicamente se encontraba constituida por una proliferación de grupos compactos de células epiteliales con marcada atipia en espacios lacunares artefactuales, y con una apariencia micropapilar. El tumor se extendía en profundidad infiltrando planos musculares (AU)

Bradykinin B1 receptors in human umbilical vein.

The present study was undertaken to demonstrate the presence of bradykinin B1 receptors mediating contraction of human umbilical vein. The bradykinin B1 receptor selective agonist, des-Arg9-bradykinin, produced a dose-dependent contractile response of human umbilical vein rings. Furthermore, des-Arga-bradykinin-mediated response increased in a time-dependent manner in vitro. The maximal response to des-Arg9-bradykinin, expressed as percentage of the maximum elicited by serotonin, was: 10 +/- 2 at 15 min, 55 +/- 5 at 120 min and 80 +/- 3 at 300 min. Des-Arg9-bradykinin-mediated contractions were inhibited by the specific bradykinin B1 receptor antagonist des-Arg9-[Leu8]bradykinin which produced parallel shifts in the dose-response curve to the selective bradykinin B1 receptor agonist. Schild regression analysis of data established a pA2 value of 6.16 +/- 0.06. Kinin-induced contraction was not modified by pre-treatment with indomethacin (10 microM), a cyclo-oxygenase inhibitor. On the other hand, continuous exposure to the anti-inflammatory steroid dexamethasone (100 microM) or to the protein synthesis inhibitor cycloheximide (70 microM) largely prevented the sensitization to des-Arg9-bradykinin in incubated human umbilical vein rings. These results confirm the presence of bradykinin B1 receptors which mediate contraction in isolated human umbilical vein. These responses are up-regulated in a time- and protein synthesis-dependent process.

Neutrophilic eccrine hidradenitis--a report of two additional cases.

Neutrophilic eccrine hidradenitis is a new neutrophilic dermatosis recently reported in association with acute myelogenous leukaemia and other malignancies, usually occurring during chemotherapy. The authors report two new cases, one of which was a patient with chronic lymphocytic leukaemia who had been treated with chlorambucil for 2 years. The clinical and histopathological features of the published cases are reviewed and the possible pathogenesis of this new syndrome is discussed.

Serum levels of apolipoproteins AI, AII and B in psoriasis.

Since an increased incidence of occlusive vascular disease has been reported in psoriasis, serum levels of apolipoproteins AI, AII and B were determined in 61 patients with the disease and compared with that of 34 healthy controls. No significant differences were found between the two groups. These findings suggest that the occurrence of thromboembolic disorders in psoriasis is not related to altered levels of apolipoproteins AI, AII, B in these patients.