RESUMO
INTRODUCTION: SARS-CoV-2 infection causes immune disorders that create conditions for the reactivation of human herpesviruses (HHVs). However, the estimates of the HHVs effect on the course and outcome of COVID-19 are ambiguous. Ðim - to study the possible relationship between the HHV reactivation and the adverse outcome of COVID-19. MATERIALS AND METHODS: Postmortem samples from the brain, liver, spleen, lymph nodes and lungs were obtained from 59 patients treated at the Moscow Infectious Diseases Hospital No.1 in 2021-2023. The group 1 comprised 39 patients with fatal COVID-19; group 2 (comparison group) included 20 patients not infected with SARS-CoV-2 who died from various somatic diseases. HHV DNA and SARS-CoV-2 RNA were determined by PCR. RESULTS: HHV DNA was found in autopsy samples from all patients. In group 1, EBV was most often detected in lymph nodes (94%), HHV-6 in liver (68%), CMV in lymph nodes (18%), HSV in brain (16%), VZV in lung and spleen (3% each). The detection rates of HHVs in both groups was similar. Important differences were found in viral load. In patients with COVID-19, the number of samples containing more than 1,000 copies of HHV DNA per 100,000 cells was 52.4%, in the comparison group - 16.6% (p < 0.002). An association has been established between the reactivation of HSV and HHV-6 and the severity of lung damage. Reactivation of EBV correlated with increased levels of liver enzymes. CONCLUSION: Reactivation of HHVs in patients with fatal COVID-19 was associated with severe lung and liver damages, which indicates a link between HHV reactivation and COVID-19 deaths.
Assuntos
Autopsia , COVID-19 , DNA Viral , Infecções por Herpesviridae , Herpesviridae , SARS-CoV-2 , Humanos , COVID-19/virologia , COVID-19/mortalidade , COVID-19/diagnóstico , COVID-19/patologia , Feminino , Masculino , DNA Viral/genética , SARS-CoV-2/genética , SARS-CoV-2/isolamento & purificação , Pessoa de Meia-Idade , Idoso , Herpesviridae/genética , Herpesviridae/isolamento & purificação , Infecções por Herpesviridae/virologia , Infecções por Herpesviridae/mortalidade , Adulto , Pulmão/virologia , Pulmão/patologia , Ativação Viral , Herpesvirus Humano 6/genética , Herpesvirus Humano 6/isolamento & purificação , Moscou , Carga Viral , Linfonodos/virologia , Linfonodos/patologia , Idoso de 80 Anos ou mais , Baço/virologia , Baço/patologiaRESUMO
A rare case of acute necrotizing encephalitis associated with influenza virus in an adult man is described. This clinical case is one of the few published cases in the world literature and the only one in the Russian literature.
Assuntos
Influenza Humana , Leucoencefalite Hemorrágica Aguda , Adulto , Encéfalo , Humanos , Imageamento por Ressonância Magnética , Masculino , Federação RussaRESUMO
The authors describe a rare clinical case of non-fatal acute necrotizing encephalitis associated with influenza virus in an adult man. This clinical case is one of the few cases published in the world literature and the only one in the Russian literature.
