RESUMO
Orbital lesions characterized by granulomatous inflammation are a heterogeneous group of diseases of various causes with a common histopathological substrate involving aggregates of epithelioid cells. Forty-one patients (27 females and 14 males) with biopsy-proven granulomatous inflammation were seen at an orbital clinic between 1978 and 1989. The mean age at presentation was 40.2 (extremes 6 and 77) years. Two main clinical presentations were noted: painless, subacute or chronic mass effect, and tender, subacute inflammatory process. Six patients had secondary features that were infiltrative in character. The lesions were primarily located in the anterior superior orbit. In nearly half the patients the granulomatous reaction was confined to the orbit (predominantly ruptured dermoid and localized orbital sarcoid), and the remainder had either regional involvement (Wegener's granulomatosis or fibro-osseous process) or systemic involvement (sarcoidosis).
Assuntos
Granuloma/diagnóstico por imagem , Doenças Orbitárias/diagnóstico por imagem , Adolescente , Adulto , Idoso , Criança , Cisticercose/diagnóstico por imagem , Cisticercose/patologia , Cisto Dermoide/diagnóstico por imagem , Cisto Dermoide/patologia , Feminino , Granuloma/patologia , Granulomatose com Poliangiite/diagnóstico por imagem , Granulomatose com Poliangiite/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Mucormicose/diagnóstico por imagem , Mucormicose/patologia , Doenças Orbitárias/patologia , Ruptura Espontânea , Sarcoidose/diagnóstico por imagem , Sarcoidose/patologia , Tomografia Computadorizada por Raios X , Xantomatose/diagnóstico por imagem , Xantomatose/patologiaRESUMO
Despite the protean ocular manifestations of acquired immune deficiency syndrome (AIDS), orbital involvement is rare and only one previous case of orbital non-Hodgkin's lymphoma (NHL) has been documented. We report a second case of NHL (large cell) of the orbit in a 28-year-old patient with a 4-year history of AIDS and review the context in which this lesion presented.
Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , Linfoma Difuso de Grandes Células B/etiologia , Neoplasias Orbitárias/etiologia , Adulto , Enzimas de Restrição do DNA , DNA de Neoplasias/isolamento & purificação , Eletroforese em Gel de Ágar , Rearranjo Gênico do Linfócito B , Genes de Imunoglobulinas/genética , Humanos , Técnicas Imunoenzimáticas , Linfoma Difuso de Grandes Células B/genética , Linfoma Difuso de Grandes Células B/patologia , Masculino , Neoplasias Orbitárias/genética , Neoplasias Orbitárias/patologia , Tomografia Computadorizada por Raios XRESUMO
Two cases of full trisomy 22 with the associated gross and microscopic pathology are reported. These cases demonstrate the typical craniofacial and organ system anomalies previously reported in trisomy 22 but also exhibit uveal colobomas that, within the spectrum of chromosome 22 anomalies, are usually restricted to the so-called "cat eye" syndrome. The attendant microscopic ocular findings represent, the best of our knowledge, the first such report in the literature.
Assuntos
Cromossomos Humanos Par 22 , Anormalidades do Olho/patologia , Trissomia , Corioide/anormalidades , Corioide/patologia , Bandeamento Cromossômico , Coloboma/patologia , Anormalidades do Olho/genética , Feminino , Humanos , Recém-Nascido , Neuroglia/patologia , Epitélio Pigmentado Ocular/anormalidades , Epitélio Pigmentado Ocular/patologiaRESUMO
A case of uveal malignant melanoma and contralateral optic nerve glioma is described in a 53-year-old Caucasian male with multiple uveal melanocytic hamartomas and neurofibromatosis. The eye was enucleated, and histologically the melanoma was found to consist of 70% epithelioid cells, with many bizarre, multinucleated forms. CT scan demonstrated a non-enhancing, fusiform enlargement of the contralateral optic nerve with enlargement of the optic canal and intracranial extension. This combination of tumours has not previously been reported in a patient with neurofibromatosis and serves to emphasise the common neuroectodermal origin of tumours in this autosomal dominant condition.
