SUBSTANTION OF THE NEED FOR MONITORING IN ENVIRONMENTAL OBJECTS OF INSECTICIDES FROM THE CLASS OF TETRAMIC AND TETRONIC ACID DERIVATIVES TAKING INTO ACCOUNT THEIR SPECIFIC INFLUENCE ON THE HUMAN ORGANISM.

OBJECTIVE: The aim: Substantiation of the need for monitoring in environmental objects of spiromesifen, spirodiclofen and spirotetramat, taking into account their specific impact on the human organism to reduce the risk of their negative influence on public health and the environment. PATIENTS AND METHODS: Materials and methods: The subject was insecticides, the class of tetramic and tetronic acids derivatives, spiromesifen, spirodiclofen and spirotetramate. Physico-chemical, toxicological and hygienic evaluation of the results was performed according to the literature data. Selection criteria were used to substantiate the needs in monitoring of these insecticides. RESULTS: Results: Spiromesifen, spirodiclofen and spirotetramate according to the Hygienic classification of pesticides by the limiting criterion of hazard belong to 1 class (strong allergen), 2 (carcinogen) and 3 classes (inhalation toxicity), respectively. The value of ADD (allowable daily dose) for human of spiromesifen, approved in Europe is 0.03 mg•kg-1. According to the assessment of hazards for professional contingents and the coefficient of possible inhalation poisoning (CPIP) and the coefficient of selective action (CSA), spiromesifen may pose a risk. We can conclude about the safety of the compound according to GUS, SCI-GROW, LEACH indices, and hence the absence of risk of potential entry of the substance into the human body with contaminated water or food. According to persistence in the environment, these insecticides are law and moderately persistent. Direct effect on the thyroid gland is absent. CONCLUSION: Conclusions: Monitoring of spiromesifen and spirotetramate in water, soil and agricultural raw materials is not obligatory, and for spirodiclofen is desirable.

HYGIENIC SUBSTANTIATION OF NECESSITY FOR MONITORING IN THE ENVIRONMENTAL OBJECTS OF SDHI FUNGICIDES CONSIDERING THEIR POSSIBLE IMPACT ON THE THYROID GLAND.

OBJECTIVE: The aim: Was hygienic substantiation of necessity for monitoring in the environmental objects of SDHI fungicides considering their possible impact on the thyroid gland. PATIENTS AND METHODS: Materials and methods: To test the proposed selection criteria for hygienic monitoring of pesticides that affect the thyroid gland, we evaluated 4 new SDHI fungicides from the chemical class of pyrazolecarboxamides (isopyrazam, pentiopyrad, sedaxan, fluxapyroxad). RESULTS: Results: Based on the results obtained, all studied compounds are assigned to the second pesticide group, hygienic monitoring of which is desirable but not required. This is due, on the one hand, to their low toxicity, to the other, to low environmental sustainability. CONCLUSION: Conclusions: It was shown, that compared to other classes of pesticides, the studied are much less dangerous in terms of groundwater contamination.

Hygienic assessment of the effects of pesticides application on children population morbidity with thyroid gland diseases.

OBJECTIVE: Introduction: It is proved that some groups of fungicides and herbicides are capable of affecting the thyroid gland, provoking its growth, leading to a compensatory change in the activity of the hormones synthesis. Therefore, the presence of their residual amounts in plant may affect the level of thyroid gland pathology. The aim of the work was to analyze the influence of pesticide application on the Ukrainian child population morbidity with thyroid diseases in the period from 2001 to 2014. PATIENTS AND METHODS: Materials and methods: The methods of empirical and theoretical research of scientific information, namely analysis, synthesis, induction, deduction and systematization, epidemiological, cartographic and statistical methods were used. RESULTS: Review: The maximum level of thyroid pathology was found in the northern, western and northwestern regions, where the diffuse goiter dominates in the morbidity and prevalence of thyroid diseases; minimal - in the southern, eastern and south-eastern regions. It was established that the highest volumes of application of chemical plant protection products in the period 2001-2013 took place in the southern and central regions of Ukraine, namely in Poltava, Vinnitsa, Kharkiv, Dnipropetrovsk, Khmelnytsky regions. Sufficiently high levels of pesticide application were in the Kyiv, Kherson regions, Zaporizhia, Kirovograd and Cherkasy regions. CONCLUSION: Conclusions: The probability of the active chemical plant protection products application effect on the level of thyroid cancer, various types of goiter, hypothyroidism, thyrotoxicosis and thyroiditis in the central and southern regions was determined. These are regions with well-developed agricultural production.

Hygienic assessment of the effects of pesticides application on adult population morbidity with thyroid gland diseases.

OBJECTIVE: Introduction: It is proved that some groups of fungicides and herbicides are capable of affecting the thyroid gland, provoking its growth, leading to a compensatory change in the activity of the hormones synthesis. Therefore, the presence of their residual amounts in plant may affect the level of thyroid gland pathology. The aim of the work was to analyze the influence of pesticide application on the Ukrainian adult population morbidity with thyroid diseases in the period from 2001 to 2014. PATIENTS AND METHODS: Materials and methods: The methods of empirical and theoretical research of scientific information, namely analysis, synthesis, induction, deduction and systematization, epidemiological, cartographic and statistical methods were used. RESULTS: Results: The maximum level of thyroid pathology was found in the northern, western and northwestern regions, where the diffuse goiter dominates in the morbidity and prevalence of thyroid diseases; minimal - in the southern, eastern and south-eastern regions. It was established that the highest volumes of application of chemical plant protection products in the period 2001-2013 took place in the southern and central regions of Ukraine, namely in Poltava, Vinnitsa, Kharkiv, Dnipropetrovsk, Khmelnytsky, Odesa and Mykolaiv regions. Sufficiently high levels of pesticide application were in the Kyiv, Kherson regions, Crimea, Zaporizhia, Kirovograd and Cherkasy regions. CONCLUSION: Conclusions: The probability of the active chemical plant protection products usage effect on the level of prevalence and incidence of thyroid cancer, various types of goiter, hypothyroidism, thyrotoxicosis and thyroiditis in the central and southern regions was determined. Are regions with well-developed agricultural production.