1.
Antibiot Med Biotekhnol
; 31(6): 434-6, 1986 Jun.
Artigo
em Russo
| MEDLINE
| ID: mdl-3740824
RESUMO
Opening of the epoxide ring in the molecule of oleandomycin phosphate in the process of its aging was shown to be possible by the data of the analysis. Certain correlation between the "glycol" content and drug activity was detected.
Assuntos
Compostos de Epóxi , Éteres Cíclicos , Oleandomicina/farmacologia , Estabilidade de Medicamentos , Armazenamento de Medicamentos , Conformação Molecular , Oleandomicina/análise , Relação Estrutura-Atividade , Temperatura
2.
Genetika
; 20(12): 2075-7, 1984 Dec.
Artigo
em Russo
| MEDLINE
| ID: mdl-6394432
RESUMO
A simple procedure for induction of nistatin-resistant mutants in yeasts under the action of 6-N-hydroxylaminopurine (HAP) is proposed. Some differences between the spectra of mutations induced by HAP and UV-light are observed: HAP induces dominant and double recessive mutants more frequently.