ADVANCING THE UNDERSTANDING OF CLINICAL SEPSIS USING GENE EXPRESSION-DRIVEN MACHINE LEARNING TO IMPROVE PATIENT OUTCOMES.

ABSTRACT: Sepsis remains a major challenge that necessitates improved approaches to enhance patient outcomes. This study explored the potential of machine learning (ML) techniques to bridge the gap between clinical data and gene expression information to better predict and understand sepsis. We discuss the application of ML algorithms, including neural networks, deep learning, and ensemble methods, to address key evidence gaps and overcome the challenges in sepsis research. The lack of a clear definition of sepsis is highlighted as a major hurdle, but ML models offer a workaround by focusing on endpoint prediction. We emphasize the significance of gene transcript information and its use in ML models to provide insights into sepsis pathophysiology and biomarker identification. Temporal analysis and integration of gene expression data further enhance the accuracy and predictive capabilities of ML models for sepsis. Although challenges such as interpretability and bias exist, ML research offers exciting prospects for addressing critical clinical problems, improving sepsis management, and advancing precision medicine approaches. Collaborative efforts between clinicians and data scientists are essential for the successful implementation and translation of ML models into clinical practice. Machine learning has the potential to revolutionize our understanding of sepsis and significantly improve patient outcomes. Further research and collaboration between clinicians and data scientists are needed to fully understand the potential of ML in sepsis management.

An Enhanced Ensemble Deep Neural Network Approach for Elderly Fall Detection System Based on Wearable Sensors.

Fatal injuries and hospitalizations caused by accidental falls are significant problems among the elderly. Detecting falls in real-time is challenging, as many falls occur in a short period. Developing an automated monitoring system that can predict falls before they happen, provide safeguards during the fall, and issue remote notifications after the fall is essential to improving the level of care for the elderly. This study proposed a concept for a wearable monitoring framework that aims to anticipate falls during their beginning and descent, activating a safety mechanism to minimize fall-related injuries and issuing a remote notification after the body impacts the ground. However, the demonstration of this concept in the study involved the offline analysis of an ensemble deep neural network architecture based on a Convolutional Neural Network (CNN) and a Recurrent Neural Network (RNN) and existing data. It is important to note that this study did not involve the implementation of hardware or other elements beyond the developed algorithm. The proposed approach utilized CNN for robust feature extraction from accelerometer and gyroscope data and RNN to model the temporal dynamics of the falling process. A distinct class-based ensemble architecture was developed, where each ensemble model identified a specific class. The proposed approach was evaluated on the annotated SisFall dataset and achieved a mean accuracy of 95%, 96%, and 98% for Non-Fall, Pre-Fall, and Fall detection events, respectively, outperforming state-of-the-art fall detection methods. The overall evaluation demonstrated the effectiveness of the developed deep learning architecture. This wearable monitoring system will prevent injuries and improve the quality of life of elderly individuals.

Deep Learning enabled Fall Detection exploiting Gait Analysis.

Falls associated injuries often result not only increasing the medical-, social- and care-cost but also loss of mobility, impair chronic health and even potential risk of fatality. Because of elderly population growth, it is one of the major global public health problems. To address such issue, we present a Deep Learning enabled Fall Detection (DLFD) method exploiting Gait Analysis. More in details, firstly, we propose a framework for fall detection system. Secondly, we discussed the proposed DLFD method which exploits fall and non-fall RGB video to extract gait features using MediaPipe framework, applies normalization algorithm and classifies using bi-directional Long Short-Term Memory (bi-LSTM) model. Finally, the model is tested on collected three public datasets of 434x2 videos(more than 1 million frames) which consists of different activities and varieties of falls. The experimental results show that the model can achieve the accuracy of 96.35% and reveals the effectiveness of the proposal. This could play a significant role to alleviate falls problem by immediate alerting to emergency and relevant teams for taking necessary actions. This will speed up the assistance proceedings, reduce the risk of prolonged injury and save lives.

Gait Evaluation Using Procrustes and Euclidean Distance Matrix Analysis.

Objective assessment of gait is important in the treatment and rehabilitation of patients with different diseases. In this paper, we propose a gait evaluation system using the Procrustes and Euclidean distance matrix analysis. We design and develop an android app to collect real time synchronous accelerometer and gyroscope data from two inertial measurement unit sensors through Bluetooth connectivity. The data is collected from 12 young (ten for modeling and two for validation) and 20 older subjects. We analyze the data collected from real world for stride, step, stance, and swing gait features. We validate our method with the measurements of gait features. The generalized Procrustes analysis is used to estimate a standard normal mean gait shape (NMGS) for ten young subjects. Each gait feature of both young and older subjects is then converted to find the best match with the NMGS using the ordinary Procrustes analysis. The shape distance between the NMGS and each gait shape is estimated using Riemannian shape distance, Riemannian size-and-shape distance, Procrustes size-and-shape distance, and root-mean-square deviation. A t-test is performed to provide statistical evidence of gait shape differences between young and older gaits. A mean form, which is considered as a standard normal mean gait form (NMGF), and inter-feature distances are estimated from the set of ten young subjects. The form difference is estimated between the NMGF and individual gaits of young and older. The degree of abnormality is then estimated for individual features and the result is plotted to visualize the feature in a gait. Experimental results demonstrate the performance of the proposed method.

An Automatic Gait Feature Extraction Method for Identifying Gait Asymmetry Using Wearable Sensors.

This paper aims to assess the use of Inertial Measurement Unit (IMU) sensors to identify gait asymmetry by extracting automatic gait features. We design and develop an android app to collect real time synchronous IMU data from legs. The results from our method are validated using a Qualisys Motion Capture System. The data are collected from 10 young and 10 older subjects. Each performed a trial in a straight corridor comprising 15 strides of normal walking, a turn around and another 15 strides. We analyse the data for total distance, total time, total velocity, stride, step, cadence, step ratio, stance, and swing. The accuracy of detecting the stride number using the proposed method is 100% for young and 92.67% for older subjects. The accuracy of estimating travelled distance using the proposed method for young subjects is 97.73% and 98.82% for right and left legs; and for the older, is 88.71% and 89.88% for right and left legs. The average travelled distance is 37.77 (95% CI ± 3.57) meters for young subjects and is 22.50 (95% CI ± 2.34) meters for older subjects. The average travelled time for young subjects is 51.85 (95% CI ± 3.08) seconds and for older subjects is 84.02 (95% CI ± 9.98) seconds. The results show that wearable sensors can be used for identifying gait asymmetry without the requirement and expense of an elaborate laboratory setup. This can serve as a tool in diagnosing gait abnormalities in individuals and opens the possibilities for home based self-gait asymmetry assessment.