Shoe-Type Walking Assist Device with Controllable Subtalar Joint Alignment at Heel Contact.

In this study, we propose a shoe-type walking assist device that can control the inversion/eversion angle of the subtalar joint during heel contact, with the aim of improving the long-term quality of life of both elderly people and young healthy people. The proposed device enables the heel mechanism to rotate dynamically in the frontal plane to lead the subtalar joint alignment to the neutral position when the heel contacts the ground. The effectiveness of the proposed mechanism was demonstrated by comparing the amount of lateral thrust (lateral sway) during stepping movements with and without the mechanism assist in 5 healthy male subjects wearing the device.

Urban spatial structures from human flow by Hodge-Kodaira decomposition.

Human flow in cities indicates social activity and can reveal urban spatial structures based on human behaviours for relevant applications. Scalar potential is a mathematical concept that, when properly applied, can provide an intuitive view of human flow. However, the definition of such a potential in terms of the origin-destination flow matrix and its feasibility remain unresolved. In this case, we use Hodge-Kodaira decomposition, which uniquely decomposes a matrix into a potential-driven (gradient) flow and a curl flow. We depict the potential landscapes in cities resulting from commuting flow and reveal how the landscapes have either changed or remained unchanged by years or methods of transportation. We then determine how well the commuting flow is described by the potential, by evaluating the percentage of the gradient component for metropolitan areas in the USA and show that the gradient component is almost 100% in several areas; in other areas, however, the curl component is dominant, indicating the importance of circular flow along with triangles of places. The potential landscape provides an easy-to-use visualisation tool for showing the attractive places of human flow and will help in a variety of applications such as commerce, urban design, and epidemic spreading.

A model for simulating emergent patterns of cities and roads on real-world landscapes.

Emergence of cities and road networks have characterised human activity and movement over millennia. However, this anthropogenic infrastructure does not develop in isolation, but is deeply embedded in the natural landscape, which strongly influences the resultant spatial patterns. Nevertheless, the precise impact that landscape has on the location, size and connectivity of cities is a long-standing, unresolved problem. To address this issue, we incorporate high-resolution topographic maps into a Turing-like pattern forming system, in which local reinforcement rules result in co-evolving centres of population and transport networks. Using Italy as a case study, we show that the model constrained solely by topography results in an emergent spatial pattern that is consistent with Zipf's Law and comparable to the census data. Thus, we infer the natural landscape may play a dominant role in establishing the baseline macro-scale population pattern, that is then modified by higher-level historical, socio-economic or cultural factors.

Physique, range of motion, and gross muscle strength in hemiplegic para swimmers: a cross-sectional case series.

[Purpose] The physical functions related to swimming should be evaluated to enhance competitive performance and prevent sports injuries. This study aimed to determine the physique, range of motion, and gross muscle strength of the limbs among hemiplegic para swimmers. [Participants and Methods] Three male para swimmers with hemiplegia and five male para swimmers with impaired vision were included in the study. The limb circumference, range of motion, quadriceps flexibility, and gross muscle strength were evaluated. The hemiplegic swimmers and swimmers with impaired vision were compared using an unpaired t-test. [Results] The maximum values of the upper and forearm circumferences; the range of motion for shoulder flexion, external rotation, ankle dorsiflexion on the paretic side; and the single-leg sit-to-stand test of the dominant limb were significantly lower in hemiplegic swimmers than in swimmers with impaired vision. [Conclusion] Hemiplegic swimmers had decreased upper limb circumferences on the paretic limb; the range of motion for shoulder flexion, external rotation, and ankle dorsiflexion on the paretic limb; and muscle strength on the dominant lower limb.

Graph-based open-ended survey on concerns related to COVID-19.

The COVID-19 pandemic is an unprecedented public health crisis with broad social and economic consequences. We conducted four surveys between April and August 2020 using the graph-based open-ended survey (GOS) framework, and investigated the most pressing concerns and issues for the general public in Japan. The GOS framework is a hybrid of the two traditional survey frameworks that allows respondents to post their opinions in a free-format style, which can subsequently serve as one of the choice items for other respondents, just as in a multiple-choice survey. As a result, this framework generates an opinion graph that relates opinions and respondents. We can also construct annotated opinion graphs to achieve a higher resolution. By clustering the annotated opinion graphs, we revealed the characteristic evolution of the response patterns as well as the interconnectedness and multi-faceted nature of opinions. Substantively, our notable finding is that "social pressure," not "infection risk," was one of the major concerns of our respondents. Social pressure refers to criticism and discrimination that they anticipate receiving from others should they contract COVID-19. It is possible that the collectivist nature of Japanese culture coupled with the government's policy of relying on personal responsibility to combat COVID-19 explains some of the above findings, as the latter has led to the emergence of vigilantes. The presence of mutual surveillance can contribute to growing skepticism toward others as well as fear of ostracism, which may have negative consequences at both the societal and individual levels.

Mental rotation ability and spontaneous brain activity: a magnetoencephalography study.

We performed experiments using magnetoencephalography to clarify the relationship between three-dimensional visuospatial abilities and spontaneous visual thinking characteristics. Subjects were divided into two groups based on the rate of correct answers to mental rotation tasks: those with good performances (Group G) and those with bad performances (Group B). We found the followings: (1) in the mental rotation tasks, the 25-35 Hz lower γ band activities in the superior parietal lobule/intraparietal sulcus regions and in the occipitotemporal region were significantly larger in Group G than in Group B and (2) in the spontaneous mental imagery tasks, the 20-Hz band activity in the left premotor cortex and the 35-Hz band activity in the supplementary motor area were significantly larger in Group G.

Optimized Alkali-Metal Cationization in Secondary Ion Mass Spectrometry of Polyethylene Glycol Oligomers with up to m/z 10000: Dependence on Cation Species and Concentration.

In secondary ion mass spectrometry (SIMS), the detection of large organic molecules is accomplished using cluster ion bombardment. Ion formation often proceeds via cationization, through the attachment of (alkali) metal ions to the molecule. To study this process, the emission of secondary ions sputtered from polyethylene glycol (PEG) samples with molecular weights (MW) of 1000-10000 was examined. They were mixed with alkali-metal trifluoroacetic acid (X-TFA, where X = Li, Na, K, or Cs) in a wide range of concentrations to investigate the efficiency of cationization for 10 keV Ar2000+ cluster irradiation. Typically, cationized molecular ions [M + X]+ (with repeat units n of up to ∼250, corresponding roughly to m/z 11000) and some characteristic fragment species were observed in the mass spectra. For all alkali cations, the oligomer intensities increase strongly with the molecular composition ratios X-TFA/PEG in the samples, and values of 5-10 seem to be optimal. With increasing molecular weight, the intensity of oligomer ions relative to the total number of ions decreases; as the latter remains rather constant, this implies that more fragment species are formed. The ion yields (detected ions per primary ions) of cationized [M + Na]+ oligomers sputtered from a PEG decrease very strongly with their size n: from 5.2 × 10-6 at n = 21 (MW ∼ 1000) to 4.5 × 10-10 at n ∼ 245 (MW ∼ 11000). By contrast, the total yields Ytot+ show only a small variation for these different specimens, from 1.3 × 10-5 to 3.7 × 10-5.

Effect of chordwise wing flexibility on flapping flight of a butterfly model using immersed-boundary lattice Boltzmann simulations.

Wing flexibility is one of the important factors not only for lift and thrust generation and enhancement in flapping flight but also for development of micro-air vehicles with flapping wings. In this study, we construct a flexible wing with chordwise flexibility by connecting two rigid plates with a torsion spring, and investigate the effect of chordwise wing flexibility on the flapping flight of a simple butterfly model by using an immersed boundary-lattice Boltzmann method. First, we investigate the effects of the spring stiffness on the aerodynamic performance when the body of the model is fixed. We find that the time-averaged lift and thrust forces and the required power increase with the spring stiffness. In addition, we find an appropriate range of the spring stiffness where the time-averaged lift and thrust forces are larger than those of the rigid wings. The mechanism of the lift and thrust enhancements is as follows: in the downstroke the flexible wings can generate not only the lift force but also the thrust force due to the deformation of wings; in the upstroke the flexible wings can generate not only the thrust force but also the lift force due to the deformation of wings. Second, we simulate free flights when the body of the model can only move translationally. We find that the model with the flexible wings at an appropriate value of the spring stiffness can fly more effectively than the model with the rigid wings, which is consistent with the results when the body of the model is fixed. Finally, we simulate free flights with pitching rotation. We find that the model gets off balance for any value of the spring stiffness. Therefore, the passive control of the pitching motion by the chordwise wing flexibility cannot be expected for the present butterfly model.

Mechanical Orthosis with Rotation Induction to Lower Leg for Patients with Knee Osteoarthritis.

Knee osteoarthritis (Knee-OA) is a disease caused by age-related muscle weakness, obesity, or sports injury, and it has been estimated to occur in approximately half of all people by the age of 85. One of the characteristics of knee-OA is rotation dyskinesia of the knee joint due to the degeneration of the system around the knee. This rotation movement, a key element of walking, is crucial for impact absorption, balanced walking, and stabilization of the knee joint. In the present study, we focused on the rotation of the lower leg relative to the movement of the ankle joint during the walking stance phase, and we developed a mechanical orthosis that induces rotation of the lower leg in conjunction with the movement of the ankle joint mechanically. The mechanical induction of rotation movement uses the movement difference due to the angle change of the inside and outside bars in conjunction with the ankle angle. We verified the effectiveness of the developed orthosis by measuring the amount of rotation and by administering the Womac test in 5 subjects with knee osteoarthritis. The results confirmed the effectiveness of our orthosis.

Manipulation of local optical properties and structures in molybdenum-disulfide monolayers using electric field-assisted near-field techniques.

Remarkable optical properties, such as quantum light emission and large optical nonlinearity, have been observed in peculiar local sites of transition metal dichalcogenide monolayers, and the ability to tune such properties is of great importance for their optoelectronic applications. For that purpose, it is crucial to elucidate and tune their local optical properties simultaneously. Here, we develop an electric field-assisted near-field technique. Using this technique we can clarify and tune the local optical properties simultaneously with a spatial resolution of approximately 100 nm due to the electric field from the cantilever. The photoluminescence at local sites in molybdenum-disulfide (MoS2) monolayers is reversibly modulated, and the inhomogeneity of the charge neutral points and quantum yields is suggested. We successfully etch MoS2 crystals and fabricate nanoribbons using near-field techniques in combination with an electric field. This study creates a way to tune the local optical properties and to freely design the structural shapes of atomic monolayers using near-field optics.

Input-output relationship in social communications characterized by spike train analysis.

We study the dynamical properties of human communication through different channels, i.e., short messages, phone calls, and emails, adopting techniques from neuronal spike train analysis in order to characterize the temporal fluctuations of successive interevent times. We first measure the so-called local variation (LV) of incoming and outgoing event sequences of users and find that these in- and out-LV values are positively correlated for short messages and uncorrelated for phone calls and emails. Second, we analyze the response-time distribution after receiving a message to focus on the input-output relationship in each of these channels. We find that the time scales and amplitudes of response differ between the three channels. To understand the effects of the response-time distribution on the correlations between the LV values, we develop a point process model whose activity rate is modulated by incoming and outgoing events. Numerical simulations of the model indicate that a quick response to incoming events and a refractory effect after outgoing events are key factors to reproduce the positive LV correlations.

Dynamic interactions of the cortical networks during thought suppression.

OBJECTIVES: Thought suppression has spurred extensive research in clinical and preclinical fields, particularly with regard to the paradoxical aspects of this behavior. However, the involvement of the brain's inhibitory system in the dynamics underlying the continuous effort to suppress thoughts has yet to be clarified. This study aims to provide a unified perspective for the volitional suppression of internal events incorporating the current understanding of the brain's inhibitory system. MATERIALS AND METHODS: Twenty healthy volunteers underwent functional magnetic resonance imaging while they performed thought suppression blocks alternating with visual imagery blocks. The whole dataset was decomposed by group-independent component analysis into 30 components. After discarding noise components, the 20 valid components were subjected to further analysis of their temporal properties including task-relatedness and between-component residual correlation. RESULTS: Combining a long task period and a data-driven approach, we observed a right-side-dominant, lateral frontoparietal network to be strongly suppression related. This network exhibited increased fluctuation during suppression, which is compatible with the well-known difficulty of suppression maintenance. CONCLUSIONS: Between-network correlation provided further insight into the coordinated engagement of the executive control and dorsal attention networks, as well as the reciprocal activation of imagery-related components, thus revealing neural substrates associated with the rivalry between intrusive thoughts and the suppression process.

In vivo ultrasound imaging of the popliteus muscle: investigation of functional characteristics.

[Purpose] The aim of this study was to use ultrasound imaging equipment for in vivo observation of the popliteus muscle thickness during rest and exercise to examine its functional characteristics and to establish a training method for this muscle. [Subjects and Methods] The subjects included 30 healthy adults (15 men and 15 women). The measurement tasks, consisting of isometric knee flexion and extension and internal rotation of the lower leg were performed in an arbitrary order. The popliteus muscle thickness was measured using an ultrasound. [Results] The popliteus muscle thickness significantly increased in the internal rotation in 27 subjects (90%), whereas, it remained unchanged in the remaining three subjects (10%). [Conclusion] This study differed from most of the previous studies because it involved in vivo observation of the popliteus muscle. We found that ultrasound was an effective method for the measurement of popliteus muscle thickness. The results suggest that internal rotation of the lower leg is the most effective exercise for working the popliteus muscle.

Temporal and structural heterogeneities emerging in adaptive temporal networks.

We introduce a model of adaptive temporal networks whose evolution is regulated by an interplay between node activity and dynamic exchange of information through links. We study the model by using a master equation approach. Starting from a homogeneous initial configuration, we show that temporal and structural heterogeneities, characteristic of real-world networks, spontaneously emerge. This theoretically tractable model thus contributes to the understanding of the dynamics of human activity and interaction networks.

Yields and images of secondary ions from organic materials by different primary Bi ions in time-of-flight secondary ion mass spectrometry.

RATIONALE: Bi cluster ions are used as a source of primary ions for time-of-flight secondary ion mass spectrometry (TOF-SIMS), and it has been recognized that secondary ion yields of macromolecules are higher with Bi cluster ions than with monomer ions or other cluster ions such as Cs(+), Ga(+) and Aun (+). However, the analysis conditions of Bi cluster TOF-SIMS are not sufficiently established. This study provides information on the secondary ion yields, damage cross-section and spatial resolution obtained with different primary Bi ions. METHODS: We investigated the secondary ion yields, damage cross-section and spatial resolution using three different primary Bi ions in TOF-SIMS. The primary ions selected were Bi1(+), Bi3(+) and Bi3(2)(+) that were accelerated with 25 kV and the positively charged secondary ions were analyzed. The samples were 1, 2-distearoyl-sn-glycero-3-phosphocholine (C44H88NO8P, DSPC), which is a typical lipid, and N,N'-di(1-naphthyl)-N,N'-diphenylbenzidine (C44H32N2, NPD) and 4,4',4"-tris[2-naphthyl(phenyl)amino]triphenylamine (C66H48N4, 2-TNATA), which are organic functional materials. RESULTS: Although the secondary ion yields of DSPC were highest when measured with Bi3(+), the spatial resolution obtained from all DSPC analyses could not be evaluated because of the low intensity of the secondary molecular ions. On the other hand, for both NPD and 2-TNATA, the secondary ion yields were highest when imaged with Bi3(2)(+). Also, we obtained the highest spatial resolution using Bi3(2)(+). In the analysis of all molecules, the damage cross-section obtained with Bi3(2)(+) was also the highest. CONCLUSIONS: When secondary ions were sensitively detected, images of the high spatial resolution were obtained by using Bi3(2)(+). On the other hand, when the secondary ion sensitivity was low, the spatial resolution depended on the yields of secondary ions, implying that the selection of the primary ion species is crucial for SIMS analysis of large molecules.

Outpatient Myelography: A Prospective Trial Comparing Complications after Myelography between Outpatients and Inpatients in Japan.

STUDY DESIGN: Prospective comparative study. PURPOSE: To compare the incidence and severity of adverse reactions associated with myelography performed in outpatients vs. in inpatients and report the safety and usefulness of outpatient myelography in Japanese patients. OVERVIEW OF LITERATURE: Myelography is normally performed as an inpatient procedure in most hospitals in Japan. No studies have reported the usefulness and adverse effects of outpatient myelography in Japanese patients. METHODS: We performed 221 myelography procedures. Eighty-five of the 221 patients underwent outpatient myelography using our new protocol. The incidence and severity of adverse reactions were compared with the other 136 patients, who underwent conventional inpatient myelography. We further compared the cost of outpatient and inpatient myelography. RESULTS: The overall rate of adverse effects was 9.4% in outpatients, as compared with 7.4% in inpatients. Overall, 1.2% of outpatients and 0.74% inpatients experienced "severe" adverse effects (requiring hospitalization). There were no significant differences between the 2 groups in either the overall rate of adverse effects or the rate of "severe" adverse effects. Moreover, the average outpatient procedure cost was only one-third to one-half that of the inpatient procedure. CONCLUSIONS: This was the first study to address the safety and usefulness of outpatient myelography in Japanese patients. If selected according to proper inclusion criteria for outpatient procedure, no significant differences were observed in the adverse effects between inpatients and outpatients. The outpatient procedure is more economical and has the added benefit of being more convenient and time-efficient for the patient.

Heterogeneity induces emergent functional networks for synchronization.

We study the evolution of heterogeneous networks of oscillators subject to a state-dependent interconnection rule. We find that heterogeneity in the node dynamics is key in organizing the architecture of the functional emerging networks. We demonstrate that increasing heterogeneity among the nodes in state-dependent networks of phase oscillators causes a differentiation in the activation probabilities of the links when a distributed local network adaptation strategy is used in an evolutionary manner. This, in turn, yields the formation of hubs associated to nodes with larger distances from the average frequency of the ensemble. Our generic local evolutionary strategy can be used to solve a wide range of synchronization and control problems.

Brain activities of visual thinkers and verbal thinkers: A MEG study.

In this study we measured activation patterns in the primary visual cortex and the frontal language areas and compared them in individuals with strong and weak capacities to mentally visualize information during spontaneous thinking. Subjects were first administered a 5-item questionnaire to assess their ability to create mental pictures, and were divided into two groups (strong and weak visualizers) on this basis. They then performed tasks requiring visual imagery and verbal recollection, and their local neural activities were measured, using magnetoencephalography (MEG). Notably in the high beta-band (25Hz), the visual area (BA 17) was more strongly activated in strong visualizers, whereas, the frontal language areas were more strongly activated in weak visualizers. Strong visualizers are considered to be visual thinkers, and weak visualizers are verbal thinkers.

Self-organization of complex networks as a dynamical system.

To understand the dynamics of real-world networks, we investigate a mathematical model of the interplay between the dynamics of random walkers on a weighted network and the link weights driven by a resource carried by the walkers. Our numerical studies reveal that, under suitable conditions, the co-evolving dynamics lead to the emergence of stationary power-law distributions of the resource and link weights, while the resource quantity at each node ceaselessly changes with time. We analyze the network organization as a deterministic dynamical system and find that the system exhibits multistability, with numerous fixed points, limit cycles, and chaotic states. The chaotic behavior of the system leads to the continual changes in the microscopic network dynamics in the absence of any external random noises. We conclude that the intrinsic interplay between the states of the nodes and network reformation constitutes a major factor in the vicissitudes of real-world networks.

Self-organization of a recurrent network under ongoing synaptic plasticity.

We investigated the organization of a recurrent network under ongoing synaptic plasticity using a model of neural oscillators coupled by dynamic synapses. In this model, the coupling weights changed dynamically, depending on the timing between the oscillators. We determined the phase coupling function of the oscillator model, Γ(ϕ), using conductance-based neuron models. Furthermore, we examined the effects of the Fourier zero mode of Γ(ϕ), which has a critical role in the case of spike-time-dependent plasticity-organized recurrent networks. Heterogeneous layered clusters with different frequencies emerged from homogeneous populations as the Fourier zero mode increased. Our findings may provide new insights into the self-assembly mechanisms of neural networks related to synaptic plasticity.