RESUMO
INTRODUCTION: An ocular manifestation may be the only location of a general disease. OBSERVATION: This is the case of a young female patient who developed placoid epitheliopathy at the age of 24. Four years later, sarcoidosis was diagnosed, with multivisceral damage and severe ophthalmological impairment, as well as skin, renal, and pulmonary involvement. DISCUSSION: Sarcoidosis and placoid epitheliopathy have similar features: the substrate, certain ophthalmological manifestations, and skin disorders. A number of atypical cases of placoid epitheliopathy with inflammatory ocular signs have been described in the literature. In parallel, cases of sarcoidosis with retinal damage, in particular to pigment epithelium, have been reported. Our recommendation is to use specific tests to investigate sarcoidosis whenever placoid epitheliopathy is diagnosed, given the vital and functional risk associated with sarcoidosis.