Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
J Agric Food Chem ; 65(31): 6582-6587, 2017 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-28731703

RESUMO

To increase the bioavailability of plant protection products, we have applied a new approach based on noncovalent association with natural water-soluble polysaccharides and oligosaccharides as delivery systems (DSs). The mechanochemical technique has been applied to prepare the solid-state nanodispersed compositions of antidote 1,8-naphthalic anhydride (NA) with arabinogalactan, sodium salt of carboxymethylcellulose, and glycyrrhizin as DSs. The effect of DSs on the solubility and the penetration of NA into the seeds of barley and wheat has been investigated by various physicochemical techniques. All DSs considerably enhance the solubility of NA and improve its penetration into the grain. The influence of polysaccharides and oligosaccharides on artificial lipid membranes was studied by the NMR relaxation method. It was concluded that the effect of polysaccharides and oligosaccharides on the penetration efficacy of plant protection products might be associated with the detected solubility enhancement and the affinity of DSs to the surface of cell membranes.


Assuntos
Portadores de Fármacos/química , Sistemas de Liberação de Medicamentos/instrumentação , Oligossacarídeos/química , Doenças das Plantas/prevenção & controle , Polissacarídeos/química , Sistemas de Liberação de Medicamentos/métodos , Ácido Glicirrízico/química , Naftalenos/química , Praguicidas/química , Praguicidas/farmacologia , Sementes/efeitos dos fármacos , Sementes/crescimento & desenvolvimento
2.
Colloids Surf B Biointerfaces ; 147: 459-466, 2016 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-27580071

RESUMO

Glycyrrhizic acid (GA) is a triterpene glycoside extracted from licorice root. Due to its amphiphilicity GA is capable of forming complexes with a variety of hydrophobic molecules, substantially increasing their solubility. GA can enhance the therapeutic effects of various drugs. It was hypothesized that the increased bioavailability of the drug by GA is not only due to increased solubility, but also to enhancement of drug permeability through cell membranes. In this study the interaction of GA with POPC liposomes and model DOPC, POPC and DPPC bilayers was investigated by NMR with addition of shift reagents and MD simulations. This work helps to better understand the mechanism of enhanced drug bioavailability in the presence of GA. NMR and MD reveal that GA does penetrate into the lipid bilayer. NMR shows that GA changes the mobility of lipids. GA is predominantly located in the outer "half-layer" of the liposome and that the middle of the hydrophobic tails is the preferred location. GA freely passes through the bilayer surface to the inner part bringing a few water molecules. Also both approaches indicate pore formation in the presence of GA. The GA interaction with membranes is an additional aspect of the biological activity of GA-based drug delivery systems.


Assuntos
Membrana Celular/química , Ácido Glicirrízico/química , Bicamadas Lipídicas/química , Lipossomos/química , Fosfatidilcolinas/química , Interações Hidrofóbicas e Hidrofílicas , Espectroscopia de Ressonância Magnética , Simulação de Dinâmica Molecular , Termodinâmica
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...