RESUMO
To determine whether genetic factors could be involved in the pathogenesis of rheumatic heart disease, we performed HLA-A and HLA-B typing in 120 black patients with severe chronic rheumatic heart disease requiring cardiac surgery, and HLA-DR and HLA-DQ typing in 103 and 97 of these patients, respectively. The HLA typing was done by a standard microlymphocytotoxicity method. Patients were 12 to 60 years old (mean 27.6 +/- 14.5). No differences in HLA-A, HLA-B, and HLA-DQ frequencies between patients and controls were noted. HLA-DR 1 antigen was present in 12.6% of patients compared with 2.7% of normal control subjects (corrected p less than .045; relative risk = 5.2) and the HLA-DRw6 antigen was present in 31.1% of patients compared with 15% of control subjects (corrected p less than .045; relative risk = 2.6). These findings suggest that genetically determined immune-response factors may play a role in the pathogenesis of severe chronic rheumatic heart disease.
Assuntos
População Negra , Antígenos HLA/análise , Antígenos HLA-D/análise , Antígenos HLA-DR/análise , Cardiopatia Reumática/genética , Adolescente , Adulto , Criança , Doença Crônica , Feminino , Antígenos HLA-A , Antígenos HLA-B , Antígenos HLA-DQ/análise , Humanos , Masculino , Pessoa de Meia-Idade , Cardiopatia Reumática/imunologia , África do SulRESUMO
The frequency of HLA-A, B, C and DR tissue antigens in 103 Indian men aged 40 years or under who had experienced a myocardial infarction was compared with the frequency in 760 healthy Indian controls. No significant differences in antigen frequencies were found. The findings in this study provide no support for either a genetic or an immunological basis for myocardial infarction in young Indian men.
Assuntos
Antígenos HLA/análise , Infarto do Miocárdio/imunologia , Adulto , Humanos , Índia/etnologia , Masculino , Infarto do Miocárdio/etnologia , África do SulRESUMO
Two-hundred-and-forty-nine Indian cancer patients were tested for 39 HLA antigens and the antigen frequencies were compared with those of 603 control subjects. Comparisons were also made between cancer patients and controls for each ethnic group and for each site of cancer. There was an increase in the frequency of the HLA antigens A11 and Bw52 in patients with malignancies. Heterozygosity at the B locus was significantly increased in patients with cancer of the breast. The Aw24, B17 haplotype was also associated with breast cancer.
Assuntos
Antígenos HLA/genética , Neoplasias/genética , Neoplasias da Mama/genética , Feminino , Frequência do Gene , Ligação Genética , Humanos , Índia/etnologia , Leucemia/genética , Leucemia/imunologia , Masculino , Neoplasias/imunologia , África do Sul , Neoplasias do Colo do Útero/genéticaRESUMO
Five hundred patients with cancer were tested for 32 HLA antigens and the antigen frequencies compared with those of 500 control subjects matched for race, sex and age. Although the overall frequencies showed no significant differences, detailed analysis with regard to site of cancer, age and the number of antigens detected at each locus revealed significant differences. Phenotype tables and haplotype frequencies have been included.
