A Bidirectional-Current CMOS Potentiostat for Fast-Scan Cyclic Voltammetry Detector Arrays.

A potentiostat circuit for the application of bipolar electrode voltages and detection of bidirectional currents using a microelectrode array is presented. The potentiostat operates as a regulated-cascode amplifier for positive input currents, and as an active-input regulated-cascode mirror for negative input currents. This topology enables constant-potential amperometry and fast-scan cyclic voltammetry (FSCV) at microelectrode arrays for parallel recording of quantal release events, electrode impedance characterization, and high-throughput drug screening. A 64-channel FSCV detector array, fabricated in a 0.5-$\mu$m, 5-V CMOS process, is also demonstrated. Each detector occupies an area of 45  $\mu$m $\times$ 30 $\mu$m and consists of only 14 transistors and a 50-fF integrating capacitor. The system was validated using prerecorded input stimuli from actual FSCV measurements at a carbon-fiber microelectrode.

A Wireless FSCV Monitoring IC With Analog Background Subtraction and UWB Telemetry.

A 30-µW wireless fast-scan cyclic voltammetry monitoring integrated circuit for ultra-wideband (UWB) transmission of dopamine release events in freely-behaving small animals is presented. On-chip integration of analog background subtraction and UWB telemetry yields a 32-fold increase in resolution versus standard Nyquist-rate conversion alone, near a four-fold decrease in the volume of uplink data versus single-bit, third-order, delta-sigma modulation, and more than a 20-fold reduction in transmit power versus narrowband transmission for low data rates. The 1.5- mm(2) chip, which was fabricated in 65-nm CMOS technology, consists of a low-noise potentiostat frontend, a two-step analog-to-digital converter (ADC), and an impulse-radio UWB transmitter (TX). The duty-cycled frontend and ADC/UWB-TX blocks draw 4 µA and 15 µA from 3-V and 1.2-V supplies, respectively. The chip achieves an input-referred current noise of 92 pA(rms) and an input current range of ±430 nA at a conversion rate of 10 kHz. The packaged device operates from a 3-V coin-cell battery, measures 4.7 × 1.9 cm(2), weighs 4.3 g (including the battery and antenna), and can be carried by small animals. The system was validated by wirelessly recording flow-injection of dopamine with concentrations in the range of 250 nM to 1 µM with a carbon-fiber microelectrode (CFM) using 300-V/s FSCV.

Wide temperature range operation of micrometer-scale silicon electro-optic modulators.

We demonstrate high bit rate electro-optic modulation in a resonant micrometer-scale silicon modulator over an ambient temperature range of 15 K. We show that low bit error rates can be achieved by varying the bias current through the device to thermally counteract the ambient temperature changes. Robustness in the presence of thermal variations can enable a wide variety of applications for dense on chip electronic photonic integration.

Analysis of intrachip electrical and optical fanout.

We examine the benefits of electrical isolation in intrachip optical signaling. We calculate the delay and energy metrics of an optical interconnect with fanout driving an electrical load. By examining fanout and including load drivers into delay equations, we make a shift from the general trend of looking at optical interconnects as a replacement for long parasitic wires. Our calculations show that optical fanout provides a large improvement in an Etau2 (energy delay squared) metric and improves performance even at very short intrachip distances. The break-even length corresponds to the wiring length of 250 minimum-size inverters that are compactly laid out. These results provide a compelling reason to further examine the implementation of optical interconnects.