An unusually large peripheral giant cell granuloma: a case report / Granuloma periférico de células gigantes inusualmente grande: reporte de un caso

Peripheral giant cell granuloma (PGCG) is a benign reactive lesion of the oral cavity. Although PGCG is classified as a tumor-like lesion, it does not represent a true neoplasm, however it is often associated with a response of local irritation and trauma. Clinically, it appears as an exophytic growth with either sessile or pedunculated base, it can be located in gingiva or edentulous alveolar mucosa and usually does not exceed two cm in diameter. The following report describes the case of a 64-year-old female diagnosed with a PGCG of a particularly large size and rapidly evolving, located in the upper jaw area. The lesion was completely excised, and the diagnosis was confirmed by histopathology, there is no apparent recurrence in the area after 12 months of follow-up. A few cases of PGCG greater than 5 cm in diameter have been reported. Furthermore, exceptional cases might present an abnormal rapid growth as well. An opportune diagnosis based on clinical examination, radiographic and histopathological study are fundamental for a prompt and efficient treatment

El granuloma periférico de células gigantes (GPCG) es una lesión reactiva benigna de la cavidad oral en respuesta a una irritación local o a un traumatismo crónico. Si bien es una lesión de aspecto tumoral, no constituye una verdadera neoplasia. Se manifiesta como un crecimiento exofítico de base sésil o pediculada, localizado en encía o procesos alveolares edéntulos y no suele sobrepasar los 2 cm de diámetro. El presente reporte describe el caso de un GPCG de tamaño anormalmente grande y rápida evolución localizado en la zona del maxilar superior en un paciente femenino de 64 años. La biopsia escisional de la lesión confirmó el diagnóstico de GPCG y a 12 meses de seguimiento no se ha presentado recidiva. Se han reportado algunos casos de GPCG de más de 5 cm de diámetro. Además, casos excepcionales también pueden presentar un crecimiento rápido anormal. Un diagnóstico oportuno basado en el examen clínico, radiográfico e histopatológico es fundamental para un tratamiento rápido y eficaz

Frozen human epidermal allogeneic cultures promote rapid healing of facial dermabrasion wounds.

BACKGROUND: Clinical studies have shown that cultured human epidermal allogenic sheets promote faster reepithelization of skin donor sites and deep partial-thickness wounds. OBJECTIVE: We describe the results of a controlled, clinical study of facial dermabrasion sites treated with a single application of frozen cultured human allogenic epidermal sheets that were thawed for 5-10 minutes at room temperature before application. METHODS: Ten patients with scars from acne or of other etiology underwent facial dermabrasion. One side of the face was treated with the frozen and thawed cultures, the other side was treated with standard dry dressing. RESULTS: The epidermal cultures promoted faster reepithelization of the wounds, with complete reepithelization in an average time of 4.6 days, whereas controls healed in an average of 7. 9 days. The reduction in healing time was 42% (P = 4.82 x 10(-7)). Pain was reduced in sites treated with the thawed cultures. CONCLUSION: Epidermal allogenic cultures, preserved by freezing, promoted significantly faster reepithelization and reduced pain intensity of dermabraded facial wounds, suggesting that they could be used routinely to improve the recovery from dermabrasion.