Compatibilidad física de la amiodarona en perfusión continua / Physical compatibility of amiodarone in continuous infusion

Objetivo. Determinar la compatibilidad física de la amiodarona administrada en «Y» con fármacos en perfusión continua con el fin de asegurar su estabilidad y garantizar una administración segura para el paciente. Método. Estudio experimental in vitro. Se determinó la compatibilidad física de la amiodarona con los fármacos más usados en la unidad de cuidados intensivos en perfusión continua, simulando las mismas condiciones que en la práctica diaria: envase, diluyente, temperatura ambiental y luz fluorescente. Todas las muestras se evaluaron mediante inspección visual, observando formación de color, turbidez, precipitación o formación de gas; medición del pH y lectura de las absorbancias a dos longitudes de onda: 450nm y 620nm para detectar cambios de color, turbidez y precipitación respectivamente. Se consideraron compatibles las mezclas que no presentaron cambios físicos, variabilidad del pH <0,50 y del rango espectral <0,010. Resultados. Se realizaron un total de 39 muestras: 14 simples, 13 dobles, 6 triples y 6 cuádruples, que se examinaron a diferentes intervalos de tiempo: 0, 15, 30, 60 y 120min. Las mezclas incompatibles presentaron cambios visuales inmediatos y valores de absorbancias superiores a 0,010nm. No hubo cambios significativos de pH durante el estudio. Conclusiones. La amiodarona es físicamente compatible con cisatracurio, esmolol, haloperidol, insulina, midazolam, morfina, nimodipino, nitroglicerina y urapidil e incompatible con el bicarbonato, furosemida, heparina y tiopental (AU)

Objective. To determine the physical compatibility of amiodarone administered in Y-site with other continuous infusion drugs, in order to ensure stability and safe delivery to the patient. Method. Experimental in vitro study. We determined the physical compatibility of amiodarone with drugs commonly used in the intensive care unit as a continuous infusion, simulating the same conditions as in daily practice: container, solvent, temperature and fluorescent light. All samples were evaluated by visual observation procedures, looking for colour changes, turbidity, precipitation or gas formation, pH measurement and spectrophotometer absorption at wavelengths: 450nm and 620nm to detect colour changes, cloudiness and precipitation, respectively. Compatible mixtures were considered as those that showed no physical changes, variability in pH <0.50 and the spectral range <0.010. Results. We analysed 39 samples: 14 single, 13 doubles, 6 triples and 6 quadruples, which were examined at different time intervals: 0, 15, 30, 60 and 120min. Non-compatible mixtures showed immediate visual changes and higher absorbance values of 0.010nm. There were no significant changes in pH during the study. Conclusions. Amiodarone is physically compatible with cisatracurium haloperidol, insulin, midazolam, morphine, nimodipine, nitroglycerin and urapidil and incompatible with bicarbonate, furosemide, heparin and thiopental (AU)

[Physical compatibility of amiodarone in continuous infusion]. / Compatibilidad física de la amiodarona en perfusión continua.

OBJECTIVE: To determine the physical compatibility of amiodarone administered in Y-site with other continuous infusion drugs, in order to ensure stability and safe delivery to the patient. METHOD: Experimental in vitro study. We determined the physical compatibility of amiodarone with drugs commonly used in the intensive care unit as a continuous infusion, simulating the same conditions as in daily practice: container, solvent, temperature and fluorescent light. All samples were evaluated by visual observation procedures, looking for colour changes, turbidity, precipitation or gas formation, pH measurement and spectrophotometer absorption at wavelengths: 450 nm and 620 nm to detect colour changes, cloudiness and precipitation, respectively. Compatible mixtures were considered as those that showed no physical changes, variability in pH < 0.50 and the spectral range < 0.010. RESULTS: We analysed 39 samples: 14 single, 13 doubles, 6 triples and 6 quadruples, which were examined at different time intervals: 0, 15, 30, 60 and 120 min. Non-compatible mixtures showed immediate visual changes and higher absorbance values of 0.010 nm. There were no significant changes in pH during the study. CONCLUSIONS: Amiodarone is physically compatible with cisatracurium haloperidol, insulin, midazolam, morphine, nimodipine, nitroglycerin and urapidil and incompatible with bicarbonate, furosemide, heparin and thiopental.