RESUMO
UNLABELLED: The high prevalence of the hepatitis C virus (HCV) infection among plasmapheresis donors has been reported in several countries and Cuba. We have studied the possible relationship between the laboratory results and the real infectious state of the anti-HCV positive individuals, as well as the possible routes of infection in this population. MATERIALS AND METHODS: Retrospective data were analyzed and a prospective monthly serologic (anti-HCV) and biochemical (alanine aminotransferase) follow-up was established to 61 regular plasmapheresis donors, negative to hepatitis B markers, of a unit, which showed a prevalence of 48.3% of infection among these donors. RESULTS AND CONCLUSION: A direct correlation between the presence of antibodies to HCV and liver injury was found. No significant connection was observed between age, sex, race or sensitizing material with the positivity to anti-HCV, but it was significant with the time in plasma donation. Our results denote the risk of transmission of the HCV infection in the plasmapheresis units, pointing out the importance of the nosocomial route of infection.
Assuntos
Doadores de Sangue , Infecção Hospitalar/transmissão , Hepacivirus/imunologia , Anticorpos Anti-Hepatite C/sangue , Hepatite C/epidemiologia , Hepatite C/transmissão , Plasmaferese , Adulto , Alanina Transaminase/sangue , Biomarcadores , Infecção Hospitalar/prevenção & controle , Cuba/epidemiologia , Feminino , Seguimentos , Hepatite C/sangue , Hepatite C/prevenção & controle , Humanos , Masculino , Pessoa de Meia-Idade , Plasmaferese/efeitos adversos , Prevalência , Estudos Retrospectivos , Estudos SoroepidemiológicosRESUMO
Comparative study of the therapeutical effects of cisapride and metoclopramide in 50 patients with symptomatic hiatal hernia was performed. Behaviour of media before and after treatment, of resting pressure and relaxation lower esophageal sphincter, pressure of the primary wave and the number of reflux episodes with pH < 4. The group of patients treated with cisapride had a considerably higher beneficial effect (p < 0.01) than the metoclopramide-treated group. A total of 4 patients were dropped-off the study because of undesirable side effects (diarrhea 2, headache 1, and somnolence 1).
Assuntos
Hérnia Hiatal/tratamento farmacológico , Metoclopramida/uso terapêutico , Piperidinas/uso terapêutico , Adolescente , Adulto , Cisaprida , Intervalos de Confiança , Avaliação de Medicamentos , Feminino , Hérnia Hiatal/epidemiologia , Hérnia Hiatal/fisiopatologia , Humanos , Masculino , Metoclopramida/efeitos adversos , Pessoa de Meia-Idade , Piperidinas/efeitos adversos , Estudos ProspectivosRESUMO
Se estudiaron los primeros 44 adultos que aparecieron en Fomento en el curso de una epidemia de Fascioliasis. Se comprobó la ingestión frecuente y reciente de berro en la población en el 88,6% de los pacientes. La fiebre no fue un signo característico observado, pero sí la eosinofilia. El 14% de los pacientes se diagnosticó por el hallazgo de huevos de Fasciola hepática en las heces y el 69% por serología
