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Carbohydr Polym ; 197: 631-640, 2018 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-30007656

RESUMO

Native (F2) and carboxyl-reduced (R) ulvans from Ulva fasciata were sequentially oxidized with periodate-chlorite affording the polycarboxyl ulvans C1, C2 and C3 (1.20, 1.41 and 1.81 mmol g-1 of COOH, respectively; 19.7, 21.3 and 21.0% of NaSO3, respectively) and R-C3 (1.86 mmol g-1 of COOH; NaSO3 = 22.7%), respectively. APTT assay (polysaccharide fractions at 150 µg mL-1) showed clotting time of 45.6 s for F2 fraction. For polycarboxyl ulvans C1, C2, C3 and R-C3 the clotting times were 101.0, 122.2, 222.0 and 227.0 s, respectively. Comparison of the APTT assay results using ulvans chemically modified by carboxyl-reduction, desulfation, periodate oxidation and/or chlorite oxidation showed the anticoagulant activity of polycarboxyl ulvans is dependent of the sulfate groups present in the native polymer. In addition, the increase of the anticoagulant activity was accompanied by the increasing of the carboxyl groups and the content of this acidic substituent seems to be more important than its positioning.


Assuntos
Anticoagulantes/farmacologia , Fatores de Coagulação Sanguínea/antagonistas & inibidores , Cloretos/farmacologia , Ácido Periódico/farmacologia , Polissacarídeos/farmacologia , Anticoagulantes/química , Cloretos/química , Relação Dose-Resposta a Droga , Conformação Molecular , Oxirredução , Ácido Periódico/química , Polissacarídeos/química
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