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Background: Relationship age, hemoglobin, and physical frailty have all been investigated in older people with more than one chronic disease. There has been little analysis of the relationship between hemoglobin, age, physical frailty, plasma levels of Sirtuin1 (SIRT1), and the gene polymorphism (SNP) rs7895833 A>G. The goal of this study was to find out how SIRT1 level, SNP rs7895833, hemoglobin, age, and physical frailty (frail score) are related in older Indonesian adults with comorbid chronic diseases. Methods: This was an observational study. Demographic and clinical data were retrieved from the electronic health records of Universitas Sumatera Utara Hospital, Medan, Indonesia. Physical frailty, SIRT1 level, and SNP rs7895833 were measured using an appropriate and valid method. Purposive sampling was used to determine the eligibility of 132 elderly adults from November 2022 to February 2023. Results: The indirect effect of hemoglobin on the frail score (FS) through age was negative and significant, according to a conditional mediation analysis (ß=-0.0731; p=0.023). Meanwhile, the direct effect of hemoglobin on the FS was negative and not significant (ß=0.1632; p=0.052). According to the conditional moderated mediation analysis, the size of the direct effect of age on FS was increased by genotype AG-GG and SIRT1 level (ß low=0.2647; p=0.002, ß middle=0.2956; p<0.001, and ß high=0.319; p<0.001). The size of the conditional indirect effect of Hemoglobin on FS through age was negative and significantly increased by SNP genotype AG-GG and SIRT1 level (ß low=-0.0647; p=0.032, ß middle=-0.0723; p=0.024, and ß high=-0.078; p=0.02). Conclusions: Higher plasma levels of SIRT1 and the SNP genotype AG-GG may both contribute to physical frailty in the elderly population. Hemoglobin levels in the blood fall with age, which can negatively impact older persons who already have chronic diseases. However, the interactions between these factors are intricate, requiring more study to completely understand the processes underlying development.
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Objective: To observe the effect of acupuncture at Quchi (LI11) on the serum interleukin-2 (IL-2) level and the severity of uremic pruritus (UP) in hemodialysis patients. Methods: Sixty hemodialysis patients with UP were randomized into an acupuncture group and a control group, with 30 cases in each group. In the acupuncture group, patients were treated with acupuncture at Quchi (LI11) twice a week for six weeks. In the control group, each patient received a placebo treatment (sham acupuncture). Before and after the intervention, the pruritis severity was examined using a 5-D scale, and the serum IL-2 level was measured using an enzyme-linked immunosorbent assay kit. Results: There were no statistically significant differences in the demographic or clinical factors between the control group and the acupuncture group at baseline. The reduction in pruritus severity in patients was more significant in the acupuncture group (P=0.027). Acupuncture therapy also significantly decreased the serum IL-2 level in the patients (P=0.011). Throughout the acupuncture procedures, the incidence of pain and mild bleeding was 3.6％ and 2.5％, respectively. Conclusion: Six-week acupuncture treatment at Quchi (LI11) can effectively decrease the severity of UP and the serum IL-2 level. Large-scale, long-duration, and multi-center studies are needed to fully understand the role of IL-2 in inflammation and neuroimmune stimulation during acupuncture.
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OBJECTIVE: To study students' perceptions based on IPE learning model in hospital. METHOD: This study is performed using a method of quantitative which involved 20 respondents from four faculties, including faculties of medicine, pharmacy, nursing, and public health. All respondents were from the Universitas Sumatera Utara, quantitative methods were based on quasi-experimental design type nonequivalent control group design pre and post interventions. The questionnaire using interprofessional Learning Readiness Scale (RIPLS) which has been validated. The data were analyzed by t-dependent. RESULTS: This study showed a significant increase in the perception (p < 0.05) on each aspect of learning IPE (except aspects of the communication and team work with p > 0.05) after this intervention. CONCLUSION: These finding conclude that the IPE model learning can be used as a strategy to make sure all aspects of professionalism can be done in medical practice in the future
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Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Estudantes de Ciências da Saúde/estatística & dados numéricos , Educação Médica/organização & administração , Aprendizagem , Percepção , Modelos Educacionais , 57419 , Relações InterprofissionaisRESUMO
Objective: Interprofessional education (IPE) includes collaborative interprofessional learning activities involving students and lecturers from the health sciences faculties at the University of Sumatera Utara. This descriptive study aimed to explore the students' perceptions of the application of the IPE program. Method: Descriptive study was conducted and one hundred sixty students were selected from four faculties including the faculties of medicine, nursing, pharmacy, and public health. Results: The results of the study showed that 68% of the participants stated that they had heard IPE information, whereas 97% reported that they had never joined in IPE activities. In the health sciences faculties, 57% of nursing students had heard IPE information, but more than 90% of the participants from the other faculties had never heard the IPE information. Also, based on aspects of their participation, all of the students reported that they had never joined in the IPE activities. Conclusions: according the results, the implementation of IPE can be realized in the integration of learning methods, such as lectures, practicum, clinical skills, and tutorials. It can be a university policy so that the implementation of IPE with specific learning methods can take place to improve the competence of collaboration students
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