RESUMO
Thirty-seven ovarian cancer-prone families have been identified through a French co-operative network. Three main clinical presentations were observed: site-specific ovarian cancer, breast/ovarian carcinoma syndrome and Lynch syndrome II. An additional kindred with features of Li-Fraumeni syndrome is reported. It is expected that a better understanding of the mechanisms of carcinogenesis will allow the development of new methods of screening and treatment. With this aim, recent studies have mapped the gene for early-onset familial breast cancer and breast/ovarian carcinoma syndrome to the same locus in the chromosome 17q12-q23 region. Results from linkage analysis of two breast/ovarian carcinoma families and three breast cancer families favour the hypothesis of genetic heterogeneity among breast and ovarian tumors.
Assuntos
Neoplasias da Mama/genética , Ligação Genética , Síndrome do Hamartoma Múltiplo/genética , Neoplasias Ovarianas/genética , Adulto , Neoplasias da Mama/complicações , Cromossomos Humanos Par 17 , Feminino , Síndrome do Hamartoma Múltiplo/complicações , Humanos , Pessoa de Meia-Idade , Neoplasias Ovarianas/complicações , LinhagemRESUMO
In Azerbaidjan, a rural province in the North-West of Iran, an hemorragic fever has been described, with a seasonal occurrence, mainly in July. it is characterized with the penia and thrombocytopenia. Its identification with the hemorragic fever of Crimea-Congo has been ruled out on clinical and biological arguments. In a new survey, fever appeared to be generally moderate or absent and the clinical aspect is that of a thrombocytopenic purpura. The role of a virus transmitted by tick, and a toxic etiology have been both suspected but not proved. Complementary surveys are necessary.
