Direct Laser Acceleration in Underdense Plasmas with Multi-PW Lasers: A Path to High-Charge, GeV-Class Electron Bunches.

The direct laser acceleration (DLA) of electrons in underdense plasmas can provide hundreds of nC of electrons accelerated to near-GeV energies using currently available lasers. Here we demonstrate the key role of electron transverse displacement in the acceleration and use it to analytically predict the expected maximum electron energies. The energy scaling is shown to be in agreement with full-scale quasi-3D particle-in-cell simulations of a laser pulse propagating through a preformed guiding channel and can be directly used for optimizing DLA in near-future laser facilities. The strategy towards optimizing DLA through matched laser focusing is presented for a wide range of plasma densities paired with current and near-future laser technology. Electron energies in excess of 10 GeV are accessible for lasers at I∼10^{21} W/cm^{2}.

Space-Time Structured Plasma Waves.

Electrostatic waves play a critical role in nearly every branch of plasma physics from fusion to advanced accelerators, to astro, solar, and ionospheric physics. The properties of planar electrostatic waves are fully determined by the plasma conditions, such as density, temperature, ionization state, or details of the distribution functions. Here we demonstrate that electrostatic wave packets structured with space-time correlations can have properties that are independent of the plasma conditions. For instance, an appropriately structured electrostatic wave packet can travel at any group velocity, even backward with respect to its phase fronts, while maintaining a localized energy density. These linear, propagation-invariant wave packets can be constructed with or without orbital angular momentum by superposing natural modes of the plasma and can be ponderomotively excited by space-time structured laser pulses like the flying focus.

Positron Generation and Acceleration in a Self-Organized Photon Collider Enabled by an Ultraintense Laser Pulse.

We discovered a simple regime where a near-critical plasma irradiated by a laser of experimentally available intensity can self-organize to produce positrons and accelerate them to ultrarelativistic energies. The laser pulse piles up electrons at its leading edge, producing a strong longitudinal plasma electric field. The field creates a moving gamma-ray collider that generates positrons via the linear Breit-Wheeler process-annihilation of two gamma rays into an electron-positron pair. At the same time, the plasma field, rather than the laser, serves as an accelerator for the positrons. The discovery of positron acceleration was enabled by a first-of-its-kind kinetic simulation that generates pairs via photon-photon collisions. Using available laser intensities of 10^{22} W/cm^{2}, the discovered regime can generate a GeV positron beam with a divergence angle of around 10° and a total charge of 0.1 pC. The result paves the way to experimental observation of the linear Breit-Wheeler process and to applications requiring positron beams.

Generation of focusing ion beams by magnetized electron sheath acceleration.

We present the first 3D fully kinetic simulations of laser driven sheath-based ion acceleration with a kilotesla-level applied magnetic field. The application of a strong magnetic field significantly and beneficially alters sheath based ion acceleration and creates two distinct stages in the acceleration process associated with the time-evolving magnetization of the hot electron sheath. The first stage delivers dramatically enhanced acceleration, and the second reverses the typical outward-directed topology of the sheath electric field into a focusing configuration. The net result is a focusing, magnetic field-directed ion source of multiple species with strongly enhanced energy and number. The predicted improvements in ion source characteristics are desirable for applications and suggest a route to experimentally confirm magnetization-related effects in the high energy density regime. We additionally perform a comparison between 2D and 3D simulation geometry, on which basis we predict the feasibility of observing magnetic field effects under experimentally relevant conditions.

Generation of megatesla magnetic fields by intense-laser-driven microtube implosions.

A microtube implosion driven by ultraintense laser pulses is used to produce ultrahigh magnetic fields. Due to the laser-produced hot electrons with energies of mega-electron volts, cold ions in the inner wall surface implode towards the central axis. By pre-seeding uniform magnetic fields on the kilotesla order, the Lorenz force induces the Larmor gyromotion of the imploding ions and electrons. Due to the resultant collective motion of relativistic charged particles around the central axis, strong spin current densities of [Formula: see text] peta-ampere/[Formula: see text] are produced with a few tens of nm size, generating megatesla-order magnetic fields. The underlying physics and important scaling are revealed by particle simulations and a simple analytical model. The concept holds promise to open new frontiers in many branches of fundamental physics and applications in terms of ultrahigh magnetic fields.

Direct laser acceleration of electrons assisted by strong laser-driven azimuthal plasma magnetic fields.

A high-intensity laser beam propagating through a dense plasma drives a strong current that robustly sustains a strong quasistatic azimuthal magnetic field. The laser field efficiently accelerates electrons in such a field that confines the transverse motion and deflects the electrons in the forward direction. Its advantage is a threshold rather than resonant behavior, accelerating electrons to high energies for sufficiently strong laser-driven currents. We study the electron dynamics via a test-electron model, specifically deriving the corresponding critical current density. We confirm the model's predictions by numerical simulations, indicating energy gains two orders of magnitude higher than achievable without the magnetic field.

Energy gain by laser-accelerated electrons in a strong magnetic field.

This paper deals with electron acceleration by a laser pulse in a plasma with a static uniform magnetic field B_{*}. The laser pulse propagates perpendicular to the magnetic field lines with the polarization chosen such that (E_{laser}·B_{*})=0. The focus of the work is on the electrons with an appreciable initial transverse momentum that are unable to gain significant energy from the laser in the absence of the magnetic field due to strong dephasing. It is shown that the magnetic field can initiate an energy increase by rotating such an electron, so that its momentum becomes directed forward. The energy gain continues well beyond this turning point where the dephasing drops to a very small value. In contrast to the case of purely vacuum acceleration, the electron experiences a rapid energy increases with the analytically derived maximum energy gain dependent on the strength of the magnetic field and the phase velocity of the wave. The energy enhancement by the magnetic field can be useful at high laser amplitudes, a_{0}≫1, where the acceleration similar to that in the vacuum is unable to produce energetic electrons over just tens of microns. A strong magnetic field helps leverage an increase in a_{0} without a significant increase in the interaction length.

Radiation reaction as an energy enhancement mechanism for laser-irradiated electrons in a strong plasma magnetic field.

Conventionally, friction is understood as a mechanism depleting a physical system of energy and as an unavoidable feature of any realistic device involving moving parts. In this work, we demonstrate that this intuitive picture loses validity in nonlinear quantum electrodynamics, exemplified in a scenario where spatially random friction counter-intuitively results in a highly directional energy flow. This peculiar behavior is caused by radiation friction, i.e., the energy loss of an accelerated charge due to the emission of radiation. We demonstrate analytically and numerically how radiation friction can dramatically enhance the energy gain by electrons from a laser pulse in a strong magnetic field that naturally arises in dense laser-irradiated plasma. We find the directional energy boost to be due to the transverse electron momentum being reduced through friction whence the driving laser can accelerate the electron more efficiently. In the considered example, the energy of the laser-accelerated electrons is enhanced by orders of magnitude, which then leads to highly directional emission of gamma-rays induced by the plasma magnetic field.

Generation of ultrahigh field by micro-bubble implosion.

Breaking the 100-MeV barrier for proton acceleration will help elucidate fundamental physics and advance practical applications from inertial confinement fusion to tumour therapy. Herein we propose a novel concept of bubble implosions. A bubble implosion combines micro-bubbles and ultraintense laser pulses of 1020-1022 W cm-2 to generate ultrahigh fields and relativistic protons. The bubble wall protons undergo volumetric acceleration toward the centre due to the spherically symmetric Coulomb force and the innermost protons accumulate at the centre with a density comparable to the interior of a white dwarf. Then an unprecedentedly high electric field is formed, which produces an energetic proton flash. Three-dimensional particle simulations confirm the robustness of Coulomb-imploded bubbles, which behave as nano-pulsars with repeated implosions and explosions to emit protons. Current technologies should be sufficient to experimentally verify concept of bubble implosions.

Enhanced Multi-MeV Photon Emission by a Laser-Driven Electron Beam in a Self-Generated Magnetic Field.

We use numerical simulations to demonstrate that a source of collimated multi-MeV photons with high conversion efficiency can be achieved using an all-optical single beam setup at an intensity of 5×10^{22} W/cm^{2} that is already within reach of existing laser facilities. In the studied setup, an unprecedented quasistatic magnetic field (0.4 MT) is driven in a significantly overdense plasma, coupling three key aspects of laser-plasma interactions at high intensities: relativistic transparency, direct laser acceleration, and synchrotron photon emission. The quasistatic magnetic field enhances the photon emission process, which has a profound impact on electron dynamics via radiation reaction and yields tens of TW of directed MeV photons for a PW-class laser.

Generation of Superponderomotive Electrons in Multipicosecond Interactions of Kilojoule Laser Beams with Solid-Density Plasmas.

The interaction of a multipicosecond, kilojoule laser pulse with a surface of a solid target has been shown to produce electrons with energies far beyond the free-electron ponderomotive limit m_{e}c^{2}a_{0}^{2}/2. Particle-in-cell simulations indicate that an increase in the pulse duration from 1 to 10 ps leads to the formation of a low-density shelf (about 10% of the critical density). The shelf extends over 100 µm toward the vacuum side, with a nonstationary potential barrier forming in that area. Electrons reflected from the barrier gain superponderomotive energy from the potential. Some electrons experience an even greater energy gain due to ponderomotive acceleration when their "dephasing rate" R=γ-p_{x}/m_{e}c drops well below unity, thus increasing acceleration by a factor of 1/R. Both 1D and 2D simulations indicate that these mechanisms are responsible for the generation of extensive thermal distributions with T_{e}>10 MeV and a high-energy cutoff of hundreds of MeV.

Ultrashort pulsed neutron source.

We report on a novel compact laser-driven neutron source with an unprecedented short pulse duration (<50 ps) and high peak flux (>10(18) n/cm(2)/s), an order of magnitude higher than any existing source. In our experiments, high-energy electron jets are generated from thin (<3 µm) plastic targets irradiated by a petawatt laser. These intense electron beams are employed to generate neutrons from a metal converter. Our method opens venues for enhancing neutron radiography contrast and for creating astrophysical conditions of heavy element synthesis in the laboratory.

Observation of self-sustaining relativistic ionization wave launched by a sheath field.

We present experimental evidence supported by simulations of a relativistic ionization wave launched into a surrounding gas by the sheath field of a plasma filament with high energy electrons. Such a filament is created by irradiating a clustering gas jet with a short pulse laser (115 fs) at a peak intensity of 5×10(17) W/cm2. We observe an ionization wave propagating radially through the gas for about 2 ps at 0.2-0.5 c after the laser has passed, doubling the initial radius of the filament. The gas is ionized by the sheath field, while the longevity of the wave is explained by a moving field structure that traps the high energy electrons near the boundary, maintaining a strong sheath field despite the significant expansion of the plasma.

Generating "superponderomotive" electrons due to a non-wake-field interaction between a laser pulse and a longitudinal electric field.

It is shown that electrons with momenta exceeding the "free electron" limit of m(e)ca(0)(2)/2 can be produced when a laser pulse and a longitudinal electric field interact with an electron via a non-wake-field mechanism. The mechanism consists of two stages: the reduction of the electron dephasing rate γ - p(x)/m(e)c by an accelerating region of electric field and electron acceleration by the laser via the Lorentz force. This mechanism can, in principle, produce electrons that have longitudinal momenta that is a significant multiple of m(e)ca(0)(2)/2. 2D particle-in-cell simulations of a relatively simple laser-plasma interaction indicate that the generation of superponderomotive electrons is strongly affected by this "antidephasing" mechanism.

Development of an interstitial ultrasound applicator for endoscopic procedures: animal experimentation.

Biliary cancer is very difficult to treat, mainly because of the advanced stage at which such tumours are detected and the low efficacy of systemic therapeutic modalities like radiotherapy. Palliative measures designed to clear the duct (either by means of surgery or an endoscopic procedure) are presently performed. A relatively noninvasive alternative could be developed to fill this gap in the therapeutic arsenal. To this end, we have designed an interstitial ultrasound (US) applicator suitable for use with a digestive endoscope. This applicator is based on a water-cooled plane transducer that operates at 10 MHz. Although, because the target zone is cylindrical in shape, it might have seemed more logical to use a cylindrical transducer. Nevertheless, a plane transducer was chosen because the pressure field from this kind of emitter decreases less quickly, which means faster and deeper heating. However, to generate coagulation necrosis all around the duct, the applicator has to be rotated around its axis; this is achieved by means of a flexible metallic shaft (2 m in length and 3. 8 mm in diameter) that joins the device's active head (which contains the transducer) to the casing with all the connectors. A holder is fixed at the endoscope channel inlet; it controls the rotation of the applicator. Trials were conducted on pigs. The duodenoscope was introduced via the oesophagus down through the duodenum as far as the hepatopancreatic ampulla. Using a guide wire, the applicator was navigated into the duct via the endoscope instrument channel. Well defined, reproducible volumes of coagulation necrosis with a diameter of 20 mm were generated in the biliary tissue and the liver. These promising results indicate that this kind of endoscopic US delivery system may represent an effective tool for the treatment of biliary tumours in humans. An Independent Ethics Committee recently approved preliminary clinical trials of this applicator.

[Laparoscopic appendectomy. Review based on an homogeneous series of 906 cases]. / Appendicectomie par voie coelioscopique. Réflexions à partir d'une série homogène de 906 cas.

PURPOSE: The aim of this retrospective study is to present the results of a large homogeneous series of laparoscopic appendicectomy. Special attention is drawn to the reasons for conversion and postoperative complications. METHODS: From May 1990 to December 1997, 906 patients were operated by laparoscopy for acute appendicitis, by one surgeon, using the same technique. Acute peritonitis and abscesses were found in 63 patients. RESULTS: There was no post-operative mortality. The overall conversion rate was 2.3 per cent, but was 25 per cent for abscesses with severe inflammatory adhesions, and 0 per cent for diffuse peritonitis. Post-operative complications were more frequent in the early period. The overall morbidity rate was 0.1 per cent, including essentially intraabdominal abscesses. CONCLUSION: A recent critical review of twelve randomized controlled trials on laparoscopic appendicectomy failed to draw any definitive conclusion because of a statistical lack of power. The present study with a large number of patients shows that laparoscopic treatment is safe. The limit of the method essentially concerns abscesses with sclerous inflammation.

Ultrasound-induced tissue ablation: studies on isolated, perfused porcine liver.

Minimally invasive methods for the treatment of cancers, such as high-intensity focused ultrasound (HIFU) and high-energy shock waves (SW), have been proposed recently. Their feasibility for treatment of human cancer needs to be confirmed. A simplified model of isolated perfused pig liver that is close to the human liver in vivo has been proposed. The objective was to study the feasibility of deep focused tissue ablation with HIFU and SW in large organs approaching the size of the human liver. The model was demonstrated to be physiologically valid during the first 2 h of anoxic perfusion with a composite saline solution; arterial and portal pressure, enzymes, urea levels and bile secretion remained stable. It can simulate the major effects of perfusion and physical phenomena that occur in vivo during treatment. Histological analysis revealed no major changes. Previous results obtained in vivo in animal models at a depth of 2-3 cm were successfully reproduced and deeper lesion arrays at 4, 6, 8 and 9 cm from the surface were produced using the same principles. The depth of 9 cm from the liver surface is consistent with an extracorporeal treatment of most of the liver segments in man. Other applications of the model are proposed, particularly for the study of the role of interferences such as ribs and intestinal gas, blood perfusion and respiratory movements.

Comparison between the effects of cavitation induced by two different pressure-time shock waveform pulses.

Acoustic cavitation generates very large localized pressures and temperatures, and thus provides a mechanism whereby physical and biological effects are produced in a high-intensity acoustic field. In this work, we studied the influence of the temporal form of a pressure pulse waveform on the destructive effects of transient cavitation. Two different shock pressure-time waveforms with nearly the same acoustic energy content were used. The first pressure waveform starts with a tensile wave followed by a compressive one, and the second pressure waveform starts with a compressive wave followed by a tensile one. These two pressure waveforms are called direct and inverse-mode pulses respectively. Based on the measurements presented in this work, we can state that, between the two types of shock pressure pulses studied, the direct-mode pulse amplifies systematically tile cavitation effect. This conclusion was achieved from a series of several quantitative and qualitative experiments: cavitation bubble collapse time, disintegration efficacy of plaster balls (a kidney stone-mimicking material), macroscopic study of lesions in agar gel and in vitro isolated rabbit liver tissue destruction. Considering these results and those obtained by other research groups, we can express that the temporal form of a shock pressure pulse has a major role on the cavitation effects.

A piezocomposite shock wave generator with electronic focusing capability: application for producing cavitation-induced lesions in rabbit liver.

In this work, a piezocomposite shock wave generator with electronic focusing capability is presented. The system is composed of a bidimensional array and its electronic hardware. The array is composed of 274 independent piezocomposite transducers arranged in a spherical shell of 280 mm in diameter and focused at 190 mm from its surface. The electronic hardware includes 274 x 6.6 kV distinct impulse generators. For the purpose of performing the electronic steering of shock waves, the delay time of each channel can be adjusted from 100 ns to 100 microseconds in steps of 100 ns. In order to enhance the effect of cavitation at the focus for the purpose of tissue destruction, the pressure-time waveform starts with a half cycle of negative pressure with a peak amplitude of about -150 x 10(5) Pa, followed by a very steep shock front with a positive peak pressure > 1000 x 10(5) Pa and a rise time of about 10 ns. Using this generator, the cavitation-induced lesions in rabbit liver were studied. To obtain a predefined lesion volume, two methods of scanning were used: mechanical and electronic. Comparison of the lesions obtained by these two methods shows that they have identical macroscopic and histological characteristics, which justify the feasibility of electronic beam steering of shock waves in tissue destruction applications.