Mechanics of 3D-Printed Polymer Lattices with Varied Design and Processing Strategies.

Emerging polymer 3D-printing technologies are enabling the design and fabrication of mechanically efficient lattice structures with intricate microscale structures. During fabrication, manufacturing inconsistencies can affect mechanical efficiency, thereby driving a need to investigate how design and processing strategies influence outcomes. Here, mechanical testing is conducted for 3D-printed lattice structures while altering topology, relative density, and exposure time per layer using digital light processing (DLP). Experiments compared a Cube topology with 800 µm beams and Body-Centered Cube (BCC) topologies with 500 or 800 µm beams, all designed with 40% relative density. Cube lattices had the lowest mean measured relative density of ~42%, while the 500 µm BCC lattice had the highest relative density of ~55%. Elastic modulus, yield strength, and ultimate strength had a positive correlation with measured relative density when considering measurement distributions for thirty samples of each design. BCC lattices designed with 50%, 40%, and 30% relative densities were then fabricated with exposure-per-layer times of 1500 and 1750 ms. Increasing exposure time per layer resulted in higher scaling of mechanical properties to relative density compared to design alteration strategies. These results reveal how design and fabrication strategies affect mechanical performance of lattices suitable for diverse engineering applications.

Simulated tissue growth in tetragonal lattices with mechanical stiffness tuned for bone tissue engineering.

Bone tissue engineering approaches have recently begun considering 3D printed lattices as viable scaffold solutions due to their highly tunable geometries and mechanical efficiency. However, scaffold design remains challenging due to the numerous biological and mechanical trade-offs related to lattice geometry. Here, we investigate novel tetragonal unit cell designs by independently adjusting unit cell height and width to find scaffolds with improved tissue growth while maintaining suitable scaffold mechanical properties for bone tissue engineering. Lattice tissue growth behavior is evaluated using a curvature-based growth model while elastic modulus is evaluated with finite element analysis. Computationally efficient modeling approaches are implemented to facilitate bulk analysis of lattice design trade-offs using design maps for biological and mechanical functionalities in relation to unit cell height and width for two contrasting unit cell topologies. Newly designed tetragonal lattices demonstrate higher tissue growth per unit volume and advantageous stiffness in preferred directions compared to cubically symmetric unit cells. When lattice beam diameter is fixed to 200 µm, Tetra and BC-Tetra lattices with elastic moduli of 200 MPa-400 MPa are compared for squashed, cubic, and stretched topologies. Squashed Tetra lattices demonstrated higher growth rates and growth densities compared to symmetrically cubic lattices. BC-Tetra lattices with the same range of elastic moduli show squashed lattices tend to achieve higher growth rates, whereas stretched lattices promote higher growth density. The results suggest tetragonal unit cells provide favorable properties for biological and mechanical tailoring, therefore enabling new strategies for diverse patient needs and applications in regenerative medicine.

Polymer 3D Printing Review: Materials, Process, and Design Strategies for Medical Applications.

Polymer 3D printing is an emerging technology with recent research translating towards increased use in industry, particularly in medical fields. Polymer printing is advantageous because it enables printing low-cost functional parts with diverse properties and capabilities. Here, we provide a review of recent research advances for polymer 3D printing by investigating research related to materials, processes, and design strategies for medical applications. Research in materials has led to the development of polymers with advantageous characteristics for mechanics and biocompatibility, with tuning of mechanical properties achieved by altering printing process parameters. Suitable polymer printing processes include extrusion, resin, and powder 3D printing, which enable directed material deposition for the design of advantageous and customized architectures. Design strategies, such as hierarchical distribution of materials, enable balancing of conflicting properties, such as mechanical and biological needs for tissue scaffolds. Further medical applications reviewed include safety equipment, dental implants, and drug delivery systems, with findings suggesting a need for improved design methods to navigate the complex decision space enabled by 3D printing. Further research across these areas will lead to continued improvement of 3D-printed design performance that is essential for advancing frontiers across engineering and medicine.