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1.
Int Dent J ; 2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38755070

RESUMO

BACKGROUND: Oral health issues have received significant attention from most global health agencies, which have integrated these issues into their noncommunicable disease, sustainable development, and universal health coverage objectives. METHODS: This paper provides an update on the progress made in the last 2 decades and aims to highlight some of the challenges faced by the oral health care system in Kuwait. RESULTS: Despite the nation's rising expenditure on oral health care, the prevalence of oral diseases remains high in Kuwait. The lack of reliable data on periodontitis and edentulism limits the ability of researchers to comment on the trends of these conditions. This emphasises the critical need for a nationwide household-level oral health survey in both pediatric and adult populations that would provide valuable information on the oral health status of these populations. CONCLUSION: In the future, Kuwait must invest more in oral disease prevention programs, especially among children and the high-risk communities of the population.

2.
BMC Oral Health ; 23(1): 757, 2023 10 13.
Artigo em Inglês | MEDLINE | ID: mdl-37833726

RESUMO

BACKGROUND: Understanding oral health behaviour s and their impact on Oral Health-Related Quality of Life (OHRQoL) may serve as an instrument to articulate the conventional oral health policy framework, thereby ameliorating the overall health of young individuals in the long term. OBJECTIVE: The aim of this study was to investigate the relationship between children's oral health behaviour s and Oral Health-Related Quality of Life in the capital governorate, Kuwait. METHODS: A cross-sectional study involving 607 children aged 12-14 years, randomly selected from schools in Kuwait Capital Region. A validated Oral Health Behaviour s and OHRQoL Child Perception Questionnaires (CPQ12-14) was used to collect the data. Chi-square, t-tests, and ANOVA were used to examine the association between oral behaviour s and children's OHRQoL. RESULTS: About 52.2% of participants were males and the overall response rate was 93.8%. The mean ± SD for total OHRQoL impact was 3.1 ± 0.58, while the total mean for individual domains- for oral symptoms, functional limitations, emotional well-being and social well-being were 2.89 ± 0.63, 2.89 ± 0.72, 3.1 ± 0.91 and 3.4 ± 0.61, respectively. There was no significant difference in total OHRQoL impact score by frequency of last dental visit, flossing, use of mouth rinse or chewing gum (p > 0.05) but for the overall OHRQoL, frequency of soft drink intake was the only significant predictor associated with 0.2-unit decrease (B = -0.207, 95% CI, p = 0.002) in total OHRQoL scores. CONCLUSIONS: High frequency of soft drink consumption was related to poorer OHRQoL. Behaviour changing interventions based on OHRQoL inferences coupled with clinical intervention are needed.


Assuntos
Cárie Dentária , Qualidade de Vida , Criança , Feminino , Humanos , Masculino , Saúde da Criança , Estudos Transversais , Comportamentos Relacionados com a Saúde , Saúde Bucal , Inquéritos e Questionários , Adolescente
3.
Oral Health Prev Dent ; 21(1): 121-130, 2023 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-37093178

RESUMO

PURPOSE: To determine the self-perceived oral health and general health as well as the oral health-related quality of life (OHRQoL) among parents in Kuwait. MATERIALS AND METHODS: This cross-sectional study was conducted among parents visiting the School Oral Health Programme (SOHP) clinics in all the governorates in Kuwait. Being a parent and able to read and understand the Arabic language was the inclusion criterion. A convenience sample of parents (n = 2357) were enrolled in this study, which was conducted using a self-administered questionnaire in Arabic. The questionnaire included previously validated questions and also questions designed for this study. The parents completed and returned the questionnaire while waiting for their children in the waiting area of the SOHP clinic. RESULTS: The mean age of the parents was 38.3 ± 7.3 years. The majority (75.2%) of the participants perceived their oral health 'excellent', 'very good' or 'good' and 76.4% also rated their general health as 'excellent', 'very good' or 'good'. Overall, higher levels of perceived oral health were reported more frequently by younger participants, females, Kuwaitis, and those who had higher levels of education (p < 0.001). Most of the participants (72.3%) were satisfied with their oral health, (91.0%) enjoyed eating their food and (79.0%) liked their smile. Perceived difficulty in chewing food was stated by only 21.0%, and very few (5.0%) had speech difficulties. Almost half (45.0%) mentioned that they had never had any dental and/or gum problems that affected their daily activities during the past 6 months, nor did such problems influence their social activities. Nearly two-thirds (61.0%) stated that they never had any difficulty in conversation, and half (49.0%) did not report any disturbance in their sleep. Cronbach's alpha (0.89) showed a high degree of internal consistency between different OHRQoL responses. CONCLUSION: Most of the parents were satisfied with their oral health, which had an impact on their quality of life.


Assuntos
Saúde Bucal , Qualidade de Vida , Criança , Feminino , Humanos , Adulto , Pessoa de Meia-Idade , Kuweit , Estudos Transversais , Pais , Inquéritos e Questionários
4.
Asian Pac J Cancer Prev ; 23(2): 459-465, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-35225457

RESUMO

BACKGROUND: Oral cancer awareness among newly graduated dentists could have a substantial impact in the prevention and early detection of oral cancer. OBJECTIVE: This survey was undertaken to assess the knowledge, opinion, attitudes, and practices on oral cancer among newly graduated dentists in Kuwait. METHODS: In this cross-sectional study, self-reported questionnaire was distributed to the newly graduated dentists. Of the 310 dentists who participated, 171 (55.2%) were males and 139 (44.8%) were females. The questionnaire included 23- questions on oral cancer knowledge, opinion, attitudes, and practices. RESULTS: The mean age of the dentists was 25.8 ± 2.4 years and their mean years of experience 1.5 ± 1.7 years. Overall, a great majority of dentists (95.8%) recognized tobacco use and alcohol consumption as very important risk factors for oral cancer occurrence. Almost all of participants were aware of the most common form of oral cancer (94.2%). Most of the dentists correctly identified the most common site of oral cancer (93.5%). Majority of the participants recognized the most commonly associated lesions with oral cancer (91.6%). While 37.4% of the dentists agreed that they were adequately trained in oral cancer screening, most (89.7%) believed that patients should have mandatory oral cancer screening at the clinics. Also, majority (95.8%) expressed their willingness to attend continuing education and training courses in cancer screening and prevention. Most of the dentists (81.9%) referred a patient with a suspicious lesion to a specialist. CONCLUSIONS: Majority of the dentists were aware and knowledgeable about various aspects of oral cancer. There is a need to emphasize and reinforce the training programs in oral cancer education mainly in prevention and early detection. Continuing education programs and workshops are highly recommended to raise awareness of the dentists on risk factors and diagnosis of oral cancer.


Assuntos
Atitude do Pessoal de Saúde , Odontólogos/psicologia , Detecção Precoce de Câncer/psicologia , Conhecimentos, Atitudes e Prática em Saúde , Neoplasias Bucais , Adulto , Estudos Transversais , Feminino , Humanos , Kuweit , Masculino , Padrões de Prática Odontológica/estatística & dados numéricos , Encaminhamento e Consulta/estatística & dados numéricos , Inquéritos e Questionários
5.
East Mediterr Health J ; 27(8): 745-754, 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34486710

RESUMO

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has rapidly spread to most countries around the world. Disproportionate spread of COVID-19 among the Indian community in Kuwait prompted heightened surveillance in this community. AIMS: To study the epidemiological characteristics of COVID-19 patients and their contacts among the Indian community in Kuwait. METHODS: Data collection was done as a part of contact tracing efforts undertaken by the Kuwaiti Ministry of Health. RESULTS: We analysed contact-tracing data for the initial 1348 laboratory-confirmed Indian patients and 6357 contacts (5681 close and 676 casual). The mean (standard deviation) age of the patients was 39.43 (10.5) years and 76.5% of the cases were asymptomatic or had only mild symptoms. Asymptomatic patients were significantly older [40.05 (10.42) years] than patients with severe symptoms [37.54 (10.54) years] (P = 0.024). About 70% of the patients were living in shared accommodation. Most of the close contacts were living in the same household, as compared with casual contacts, who were primarily workplace contacts (P < 0.001). Among the different occupations, healthcare workers had the highest proportion of cases (18.4%). Among the 216 pairs of cases with a clear relationship between the index and secondary cases, the mean serial interval was estimated to be 3.89 (3.69) days, with a median of 3 and interquartile range of 1-5 days. CONCLUSION: An early increase in the number of COVID-19 cases among the Indian community could be primarily attributed to crowded living conditions and the high proportion of healthcare workers in this community.


Assuntos
COVID-19 , Adulto , COVID-19/etnologia , Busca de Comunicante , Humanos , Índia/etnologia , Kuweit/epidemiologia , Pessoa de Meia-Idade , Pandemias
6.
Oral Health Prev Dent ; 19(1): 245-253, 2021 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-33881287

RESUMO

PURPOSE: To determine the oral health status among adult employees in Kuwait. MATERIALS AND METHODS: This cross-sectional study was performed on a convenience sample (n = 1294) of adult employees. Their ages ranged from 19 to 77 years (mean 36.2). Six trained and calibrated dentists examined them using a mouth mirror and a WHO ball-tip probe. Caries was scored using WHO diagnostic criteria. The debris index simplified (DI-S) score was used to assess oral hygiene status. RESULTS: Overall, the mean DMFT in the adults was 10.3. The DMFT increased from 7.8 for the age group 19-24 years to 10.7 at 35-44 years and 18.9 at 65-77 years (p < 0.001). Females had slightly higher caries experience (DMFT) (11.0) than did males (10.1) (p = 0.021), and Kuwaitis (11.1) more than non-Kuwaitis (8.9) (p < 0.001). The proportion of caries-free adults was 28%. In multivariate analysis, adults with poor oral hygiene (OR=1.5; 95% CI=1.2-2.1), those with an intermediate-school (grades 6 to 9) or lower level of education (OR=2.6; 95% CI=1.4-4.7), Kuwaitis (OR=1.3; 95% CI=1.0-1.7), those with oral pain (OR=1.4; 95% CI=1.0-1.8), and those needing urgent dental care (OR=4.6; 95% CI=2.6-8.0) were statistically significantly associated with caries risk. About 19.6% of these adults had good, 36.1% fair and 44.4% had poor oral hygiene. Nearly one-third (32.9%) of adults had perceived oral pain at the time of examination. CONCLUSION: Implementing oral health programs is needed and efforts should be made to promote oral hygiene practices in workplaces among adults in Kuwait.


Assuntos
Cárie Dentária , Saúde Bucal , Adulto , Idoso , Estudos Transversais , Índice CPO , Cárie Dentária/epidemiologia , Feminino , Humanos , Kuweit/epidemiologia , Masculino , Pessoa de Meia-Idade , Higiene Bucal , Prevalência , Adulto Jovem
7.
Artigo em Inglês | MEDLINE | ID: mdl-31281289

RESUMO

In a longitudinal study of 6,158 Kuwaiti children, we selected 94 for salivary metabolomic analysis who were neither obese (by waist circumference) nor metabolic syndrome (MetS) positive (<3 diagnostic features). Half (43) remained healthy for 2 years. The other half (51) were selected because they became obese and MetS positive 2 years later. In the half becoming obese, metabolomic analysis revealed that the level of salivary N1-Methyl-2-pyridone-5-carboxamide (2PY) had the highest positive association with obesity (p = 0.0003, AUC = 0.72) of 441 salivary biochemicals detected. 2PY is a recognized uremic toxin. Also, 2PY has been identified as a biomarker for uranium uptake. Considering that a relatively recent military conflict with documented uranium contamination of the area suggests that this weight gain could be a toxicological effect of long-time, low-level uranium ingestion. Comparison of salivary 2PY in samples from the USA and Kuwait found that only Kuwait samples were significantly related to obesity. Also, the geographic distribution of both reported soil radioactivity from 238U and measured salivary 2PY was highest in the area where military activity was highest. The prevalence pattern of adult diabetes in Kuwait suggests that a transient diabetogenic factor has been introduced into the Kuwaiti population. Although we did not measure uranium in our study, the presence of a salivary biomarker for uranium consumption suggests potential toxicity related to obesity in children.

8.
Asian Pac J Cancer Prev ; 20(5): 1531-1536, 2019 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-31128059

RESUMO

Background: Oral cancer signifies a public health concern of international importance. Early detection of oral cancer can improve the prognosis and the 5-year survival rate. Objective: The aim of this study was to assess the level of oral cancer knowledge, opinion, attitudes and practices among dentists working at the primary oral health care centers in Kuwait. Methods: In this cross-sectional study, self-reported questionnaire was distributed to the dentists working at the primary oral health care centers in Kuwait. A total of 289 dentists participated in the present study. The questionnaire included 23- questions on oral cancer knowledge, opinion, attitudes and practices. Results: The mean age of the dentists was 35.2 ± 10.9 years. Approximately, all dentists (99.7%) were aware of the major risk factors that were most likely associated with oral cancer. Overall, majority of the participants knew the most common form of oral cancer (80.6%), most common site (80.3%) and the likely lesions associated with oral cancer occurrence (87.9%). A large number of dental practitioners (81%) would routinely refer a patient with a suspicious lesion to a specialist. Nearly one-third (32%) reviewed their patients' oral cancer risk factors. Approximately two-thirds (62%) assessed the use of tobacco in their practice. Almost, all (92.4%) were interested in attending continuing education courses on oral cancer. Conclusions: Majority of the participants presented good knowledge about various aspects of oral cancer. More continuing education programs on risk factors and diagnosis of oral cancer should be organized to train the dentists. Oral cancer screening should be a routine procedure for the high risk patients at the primary oral health care centers in Kuwait.


Assuntos
Odontólogos/estatística & dados numéricos , Conhecimentos, Atitudes e Prática em Saúde , Neoplasias Bucais/diagnóstico , Padrões de Prática Odontológica/estatística & dados numéricos , Atenção Primária à Saúde/estatística & dados numéricos , Adulto , Atitude do Pessoal de Saúde , Estudos Transversais , Detecção Precoce de Câncer/estatística & dados numéricos , Feminino , Humanos , Kuweit , Masculino , Saúde Bucal , Fatores de Risco , Autorrelato , Inquéritos e Questionários
9.
PLoS One ; 12(3): e0170437, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28249034

RESUMO

BACKGROUND: Type II diabetes (T2D) has been associated with changes in oral bacterial diversity and frequency. It is not known whether these changes are part of the etiology of T2D, or one of its effects. METHODS: We measured the glucose concentration, bacterial counts, and relative frequencies of 42 bacterial species in whole saliva samples from 8,173 Kuwaiti adolescents (mean age 10.00 ± 0.67 years) using DNA probe analysis. In addition, clinical data related to obesity, dental caries, and gingivitis were collected. Data were compared between adolescents with high salivary glucose (HSG; glucose concentration ≥ 1.0 mg/d, n = 175) and those with low salivary glucose (LSG, glucose concentration < 0.1 mg/dL n = 2,537). RESULTS: HSG was associated with dental caries and gingivitis in the study population. The overall salivary bacterial load in saliva decreased with increasing salivary glucose concentration. Under HSG conditions, the bacterial count for 35 (83%) of 42 species was significantly reduced, and relative bacterial frequencies in 27 species (64%) were altered, as compared with LSG conditions. These alterations were stronger predictors of high salivary glucose than measures of oral disease, obesity, sleep or fitness. CONCLUSIONS: HSG was associated with a reduction in overall bacterial load and alterations to many relative bacterial frequencies in saliva when compared with LSG in samples from adolescents. We propose that hyperglycemia due to obesity and/or T2D results in HSG and subsequent acidification of the oral environment, leading to a generalized perturbation in the oral microbiome. This suggests a basis for the observation that hyperglycemia is associated with an increased risk of dental erosion, dental caries, and gingivitis. We conclude that HSG in adolescents may be predicted from salivary microbial diversity or frequency, and that the changes in the oral microbial composition seen in adolescents with developing metabolic disease may the consequence of hyperglycemia.


Assuntos
Bactérias , Diabetes Mellitus Tipo 2 , Glucose/metabolismo , Microbiota , Saliva , Adolescente , Bactérias/classificação , Bactérias/crescimento & desenvolvimento , Bactérias/isolamento & purificação , Criança , Diabetes Mellitus Tipo 2/metabolismo , Diabetes Mellitus Tipo 2/microbiologia , Feminino , Humanos , Masculino , Saliva/metabolismo , Saliva/microbiologia
10.
Oral Health Prev Dent ; 14(6): 519-528, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27957562

RESUMO

PURPOSE: To measure oral health (OH) knowledge, attitude and practices (KAP) of primary school teachers and to evaluate the relationship between these measures and oral health-related quality of life (OHRQoL). MATERIALS AND METHODS: A total of 1013 school teachers from all regions of Kuwait were randomly selected in this cross-sectional study. A questionnaire on demographics, knowledge, attitude, practices and OHRQoL was used. Frequencies and means (SD) were used for data description. Correlations between KAP and OHRQoL were evaluated using Pearson's correlation coefficient. Associations between practice-specific knowledge and its corresponding practice as well as knowledge and practices and OHRQoL were determined using the chi-squared test. RESULTS: About 71% of the participants were females, 57% were 30-50 years old, and 75% had a college education. The mean (95%CI) knowledge score was 60.2% (57.2-62.0), ranging from 15.4% to 93%. The well-known OH facts were the importance of brushing twice a day with fluoridated toothpaste, the cariogenic effect of sticky, sugary foods and snacks, as well as the damage that soft drinks can cause to teeth. The least known facts were replacement frequency of toothbrush, parent's supervision of children's brushing and the benefit of regular flossing. Weak but significant correlations were found between KAP components and OHRQoL (p < 0.05). All practice-specific OH knowledge was significantly associated with its practice, except brushing and flossing (p > 0.05). Self-esteem was the mostly frequently affected OHRQoL construct by improper OH practices. CONCLUSION: Oral health knowledge by itself is not enough to change improper OH practices. Developing behaviourchanging interventions based on OHRQoL outcomes may be beneficial.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Saúde Bucal , Qualidade de Vida , Professores Escolares , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Instituições Acadêmicas , Autorrelato
11.
J Obes ; 2016: 6860240, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27069678

RESUMO

OBJECTIVE: Here, we investigated the relationships between obesity and the salivary concentrations of insulin, glucose, and 20 metabolic biomarkers in Kuwaiti adolescents. Previously, we have shown that certain salivary metabolic markers can act as surrogates for blood concentrations. METHODS: Salivary samples of whole saliva were collected from 8,317 adolescents. Salivary glucose concentration was measured by a high-sensitivity glucose oxidase method implemented on a robotic chemical analyzer. The concentration of salivary insulin and 20 other metabolic biomarkers was assayed in 744 randomly selected saliva samples by multiplexed bead-based immunoassay. RESULTS: Obesity was seen in 26.5% of the adolescents. Salivary insulin predicting hyperinsulinemia occurred in 4.3% of normal-weight adolescents, 8.3% of overweight adolescents, and 25.7% of obese adolescents (p < 0.0001). Salivary glucose predicting hyperglycemia was found in only 3% of obese children and was not predictive (p = 0.89). Elevated salivary glucose and insulin occurring together was associated with elevated vascular endothelial growth factor and reduced salivary interleukin-12. CONCLUSION: Considering the surrogate nature of salivary insulin and glucose, this study suggests that elevated insulin may be a dominant sign of metabolic disease in adolescent populations. It also appears that a proangiogenic environment may accompany elevated glucose in obese adolescents.


Assuntos
Glucose/metabolismo , Interleucina-12/metabolismo , Obesidade Infantil/metabolismo , Saliva/metabolismo , Fator A de Crescimento do Endotélio Vascular/metabolismo , Adolescente , Biomarcadores/metabolismo , Feminino , Humanos , Insulina , Resistência à Insulina , Kuweit/epidemiologia , Masculino , Obesidade Infantil/epidemiologia , Obesidade Infantil/fisiopatologia , Fenótipo , Valor Preditivo dos Testes , Fatores de Risco
12.
Pediatr Endocrinol Rev ; 13(3): 602-11, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27116847

RESUMO

The increasing prevalence of childhood obesity and obesity-related metabolic disorders is now considered a global pandemic. The main goal of the pediatric obesity research community is to identify children who are at risk of becoming obese before their body mass index rises above age norms. To do so, we must identify biomarkers of metabolic health and immunometabolism that can be used for large-scale screening and diagnosis initiatives among at-risk children. Because blood sampling is often unacceptable to both parents and children when there is no direct benefit to the child, as in a community-based research study, there is a clear need for a low-risk, non-invasive sampling strategy. Salivary analysis is now well recognized as a likely candidate for this purpose. In this review, we discuss the physiologic role of saliva and its strengths and limitations as a fluid for biomarker discovery, obesity screening, metabolic disease diagnosis, and response monitoring after interventions. We also describe the current state of the salivary biomarker field as it pertains to metabolic research, with a special emphasis on studies conducted in children and adolescents. Finally, we look forward to technological developments, such as salivary "omics" and point of service diagnostic devices, which have the potential to accelerate the pace of research and discovery in this vitally important field.


Assuntos
Biomarcadores/metabolismo , Pesquisa Biomédica/tendências , Doenças Metabólicas/etiologia , Saliva/metabolismo , Adolescente , Biomarcadores/análise , Criança , Humanos , Doenças Metabólicas/diagnóstico , Doenças Metabólicas/terapia , Obesidade Infantil/diagnóstico , Obesidade Infantil/epidemiologia , Saliva/química , Manejo de Espécimes/métodos , Manejo de Espécimes/normas
13.
Oral Health Prev Dent ; 14(4): 349-54, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26870848

RESUMO

PURPOSE: To evaluate sealant retention in a multi-operator school-based oral health programme and sealant efficacy in preventing caries in a high caries-risk population. MATERIALS AND METHODS: Sealant retention and caries status in previously placed sealants on permanent first molars were evaluated in 503 children ages 6 to 8 years at 20 primary schools. A total of 2538 sealants were applied on 876 first permanent molars and evaluated for retention and efficacy in preventing caries from 2002 to 2007. These sealants were placed on occlusal and buccal or palatal surfaces using a standard protocol after isolation with rubber-dam or cotton roll. Caries was scored in teeth in which the sealants were partially or completely lost. RESULT: 1752 sealants (69%) were examined at the end of the fifth year, with 58.3% of the sealants completely retained, 7.4% partially lost, 19% completely lost, 6.2% resealed and 9.1% restored. Only 3.1% of the previously sealed teeth were carious and 87.8% of previously sealed teeth were caries free. In multivariate analysis, occlusal surfaces were 2.0 times more likely to retain a sealant than were the buccal and palatal pits (p < 0.0001). No differences in sealant retention vs caries by arch, or teeth isolated using rubber-dam vs cotton roll were seen. CONCLUSION: The present study shows the effectiveness of sealants in caries prevention in a multi-operator school sealant programme, and provides evidence supporting their use in such programmes for high-caries populations.


Assuntos
Saúde Bucal , Selantes de Fossas e Fissuras , Adolescente , Criança , Humanos , Kuweit , Instituições Acadêmicas
14.
PLoS One ; 10(9): e0138979, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26418011

RESUMO

BACKGROUND: Binary definitions of the metabolic syndrome based on the presence of a particular number of individual risk factors are limited, particularly in the pediatric population. To address this limitation, we aimed at constructing composite and continuous metabolic syndrome scores (cmetS) to represent an overall measure of metabolic syndrome (MetS) in a large cohort of metabolically at-risk children, focusing on the use of the usual clinical parameters (waist circumference (WC) and systolic blood pressure (SBP), supplemented with two salivary surrogate variables (glucose and high density lipoprotein cholesterol (HDLC). Two different approaches used to create the scores were evaluated in comparison. METHODS: Data from 8,112 Kuwaiti children (10.00 ± 0.67 years) were used to construct two cmetS for each subject. The first cmetS (cmetS-Z) was created by summing standardized residuals of each variable regressed on age and gender; and the second cmetS (cmetS-PCA) was defined as the first principal component from gender-specific principal component analysis based on the four variables. RESULTS: There was a graded relationship between both scores and the number of adverse risk factors. The areas under the curve using cmetS-Z and cmetS-PCA as predictors for severe metabolic syndrome (defined as the presence of ≥3 metabolic risk factors) were 0.935 and 0.912, respectively. cmetS-Z was positively associated with WC, SBP, and glucose, but inversely associated with HDLC. Except for the lack of association with glucose, cmetS-PCA was similar to cmetS-Z in boys, but had minimum loading on HDLC in girls. Analysis using quantile regression showed an inverse association of fitness level with cmetS-PCA (p = 0.001 for boys; p = 0.002 for girls), and comparison of cmetS-Z and cmetS-PCA suggested that WC and SBP were main contributory components. Significant alterations in the relationship between cmetS and salivary adipocytokines were demonstrated in overweight and obese children as compared to underweight and normal-weight children. CONCLUSION: We have derived continuous summary scores for MetS from a large-scale pediatric study using two different approaches, incorporating salivary measures as surrogate for plasma measures. The derived scores were viable expressions of metabolic risk, and can be utilized to study the relationships of MetS with various aspects of the metabolic disease process.


Assuntos
Biomarcadores/análise , Síndrome Metabólica/diagnóstico , Obesidade/complicações , Saliva/química , Índice de Massa Corporal , Criança , Estudos de Coortes , Feminino , Humanos , Masculino , Síndrome Metabólica/etiologia , Síndrome Metabólica/metabolismo , Prognóstico , Fatores de Risco , Circunferência da Cintura
15.
Artigo em Inglês | MEDLINE | ID: mdl-25565874

RESUMO

BACKGROUND: Metabolic syndrome in childhood predicts the development of cardiovascular disease and type 2 diabetes (T2D) in adulthood. Testing for features of metabolic syndrome, such as fasting plasma glucose concentration, requires blood sampling which can be difficult in children. Here we evaluated salivary glucose concentration as a surrogate measurement for plasma glucose concentration in 11-year-old US children. METHODS: Children from Portland, Maine, and Cambridge, Massachusetts, with a mean age of 10.6±0.2 years provided 6-hour fasting samples of both blood and whole saliva. Salivary glucose levels were measured with a high-sensitivity assay (sensitivity =0.002 mg/dL). Plasma glucose levels were determined by a commercial clinical laboratory. Blood pressure, salivary flow rate, height, and weight were also measured. RESULTS: Of the 65 children enrolled, there were two underweight children (3.1%), 30 normal-weight children (46.2%), 12 overweight children (18.4%), and 21 obese children (32.3%). The mean overall glucose concentrations were 0.11±0.02 mg/dL in saliva and 86.3±0.8 mg/dL in plasma, and these did not differ significantly by body-weight groups. By regression analysis, the plasma concentration equaled 13.5 times the saliva concentration, with a threshold level of 84.8 mg/dL. Salivary glucose values less than threshold plasma concentration were essentially zero. Diagnostic analysis indicated a positive predictive value of 50%, a negative predictive value of 90%, and a sensitivity and specificity both of approximately 75%. The salivary glucose concentration did not vary with saliva flow rate. CONCLUSION: Taking into account the threshold response characteristics of the salivary glucose concentration response, these results suggest that testing salivary glucose levels may be useful as a screening assay for high fasting plasma glucose levels. The low false positive value is important to assure a low fraction of missed diagnoses.

16.
PLoS One ; 9(6): e98799, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24915044

RESUMO

OBJECTIVE: The study of obesity-related metabolic syndrome or Type 2 diabetes (T2D) in children is particularly difficult because of fear of needles. We tested a non-invasive approach to study inflammatory parameters in an at-risk population of children to provide proof-of-principle for future investigations of vulnerable subjects. DESIGN AND METHODS: We evaluated metabolic differences in 744, 11-year old children selected from underweight, normal healthy weight, overweight and obese categories by analyzing fasting saliva samples for 20 biomarkers. Saliva supernatants were obtained following centrifugation and used for analyses. RESULTS: Salivary C-reactive protein (CRP) was 6 times higher, salivary insulin and leptin were 3 times higher, and adiponectin was 30% lower in obese children compared to healthy normal weight children (all P<0.0001). Categorical analysis suggested that there might be three types of obesity in children. Distinctly inflammatory characteristics appeared in 76% of obese children while in 13%, salivary insulin was high but not associated with inflammatory mediators. The remaining 11% of obese children had high insulin and reduced adiponectin. Forty percent of the non-obese children were found in groups which, based on biomarker characteristics, may be at risk for becoming obese. CONCLUSIONS: Significantly altered levels of salivary biomarkers in obese children from a high-risk population, suggest the potential for developing non-invasive screening procedures to identify T2D-vulnerable individuals and a means to test preventative strategies.


Assuntos
Doenças Metabólicas/epidemiologia , Doenças Metabólicas/metabolismo , Saliva/metabolismo , Adiponectina/metabolismo , Biomarcadores/metabolismo , Índice de Massa Corporal , Peso Corporal , Proteína C-Reativa/metabolismo , Criança , Feminino , Humanos , Mediadores da Inflamação/metabolismo , Insulina/metabolismo , Leptina/metabolismo , Masculino , Risco
17.
Med Princ Pract ; 23 Suppl 1: 43-6, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24335161

RESUMO

The School Oral Health Program (SOHP), Kuwait, is a joint venture between the Ministry of Health, Kuwait, and Forsyth Institute, Cambridge, Mass., USA. This program provides oral health education, prevention and treatment to almost 280,000 public school children in Kuwait. Services are delivered through a system of center- and school-based clinics and preventive mobile teams. One of the recent developments is the effective use of portable dental units for the delivery of preventive care to children in schools without the need for children to go to dental clinics. Preventive procedures performed under this program are the biannual application of fluoride varnish and the placement of pit and fissure sealants on newly erupted permanent molars and premolars. During recent years, the SOHP has improved its coverage of children, with prevention up to 80%. This has resulted in a considerable reduction in treatment needs, which is evident from the reduced number of composite restorations performed under this program during the last 6 years. This indicates that the disease level is on a decline, which can be confirmed from the results of the ongoing National Oral Health Survey on Kuwaiti school children.


Assuntos
Serviços de Saúde Bucal/organização & administração , Serviços de Saúde Bucal/estatística & dados numéricos , Educação em Saúde Bucal/organização & administração , Saúde Bucal , Odontologia Preventiva/estatística & dados numéricos , Serviços de Saúde Escolar/organização & administração , Humanos , Kuweit
18.
Med Princ Pract ; 23(2): 125-8, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24356643

RESUMO

OBJECTIVE: The purpose of this study was to describe the oral health, oral hygiene, and oral health habits of Kuwaiti infants and toddlers. SUBJECTS AND METHODS: This cross-sectional study of a convenience sample included 336 infants and toddlers (156 females and 180 males). The teeth of the infants and toddlers were examined using a mirror and a light source. Oral hygiene was recorded, and then all teeth were cleaned with gauze and examined for caries. Parents were interviewed regarding their children's feeding habits, brushing or tooth cleaning, and night feeding. The evaluation criteria for caries were sound teeth, noncavitated lesions, cavitated lesions, filled teeth, and missing teeth. RESULTS: The mean age was 11.1 ± 2.4 months (range 2-23). Of the 336 subjects, 247 (73%) had good oral hygiene, 64 (19%) had parents who brushed or cleaned their infants' and toddlers' teeth; 288 (86%) were bottle-fed, and 290 (86%) were also night fed. The mean number of teeth upon examination was 4.6 ± 2.7 (range 2-8). Three percent of the infants and toddlers had caries. Cavitated lesions were present in 6 patients (1.8%), while 4 (1.2%) had noncavitated lesions. The mean d1d2t (caries teeth: noncavitated lesions and cavitated lesions) was 0.03 ± 0.3, and the mean d1d2s (carious surfaces) was 0.07 ± 0.5. CONCLUSION: The caries prevalence and severity was low in infants and toddlers. However, poor oral health practices and habits as well as unhealthy feeding practices that could affect the future caries prevalence were noted.


Assuntos
Cárie Dentária/epidemiologia , Saúde Bucal/estatística & dados numéricos , Higiene Bucal/estatística & dados numéricos , Estudos Transversais , Comportamento Alimentar , Feminino , Humanos , Lactente , Masculino , Prevalência , Escovação Dentária/estatística & dados numéricos
19.
PLoS One ; 8(10): e74461, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24130667

RESUMO

OBJECTIVE: To evaluate the relationship of children's obesity and dental decay. METHODS: We measured parameters related to obesity and dental decay in 8,275 4(th) and 5(th) grade Kuwaiti children (average age = 11.36 years) in a cross-sectional study. First to determine body weight, height, age for computation of BMI . Second, to determine numbers of teeth, numbers of fillings and numbers of untreated decayed teeth to determine extent and severity of dental disease. From these measurements, we computed measures of dental decay in children from four body weight categories; obese, overweight, normal healthy weight and underweight children. RESULTS: The percentage of children with decayed or filled teeth varied inversely with the body weight category. The percentage of decayed or filled teeth decreased from 15.61% (n=193) in underweight children, to 13.03% (n=4,094) in normal healthy weight children, to 9.73% (n=1,786) in overweight children to 7.87% (n=2,202) in obese children. Differences between all groups were statistically significant. Male children in this population had more dental decay than female children but the reduction of tooth decay as a function of BMI was greater in male children. CONCLUSIONS: The finding of an inverse obesity-dental decay relationship contradicts the obesity-sugar and the obesity-dental decay relationship hypotheses. Sugar is well recognized as necessary and sufficient for dental decay. Sugar is also hypothesized to be a leading co-factor in obesity. If the later hypothesis is true, one would expect dental decay to increase with obesity. This was not found. The reasons for this inverse relationship are not currently clear.


Assuntos
Cárie Dentária/epidemiologia , Obesidade/epidemiologia , Adolescente , Peso Corporal/fisiologia , Criança , Pré-Escolar , Estudos Transversais , Sacarose Alimentar , Feminino , Humanos , Kuweit , Masculino , Fatores Sexuais
20.
Med Princ Pract ; 22(1): 12-7, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-22889920

RESUMO

OBJECTIVE: This study evaluated the effectiveness of sealant retention and caries prevention with and without primer and bond below the fissure sealant among Kuwaiti schoolchildren. SUBJECTS AND METHODS: This clinical trial used fissure sealant that was applied to four sound first permanent molars on 78 children. All the teeth were cleaned with pumice and rubber cups, isolated with rubber dams, and etched for 20 s. In a split-mouth study design, for the test teeth (n = 156), primer and bond (3M Scotchbond Multi-Purpose Plus System primer and bond) were applied below the sealant, and for the control teeth (n = 156), only sealant (Delton Plus) was applied. The number of tooth surfaces included was 480. Due to loss to follow-up, only 60 children were evaluated at 5 years for sealant retention and caries. The evaluation criteria were: completely retained sealant, complete or partial sealant retention, and caries. RESULTS: In teeth sealed with primer and bond, 47 (19.6%) tooth surfaces had completely retained sealant, 60 (9.2%) teeth had partially retained sealant, while in 51 (21.3%) caries was prevented and 120 (50%) tooth surfaces were carious or filled. In teeth sealed without primer and bond, 25% (60 tooth surfaces) had completely retained sealant, 6% (14 teeth surfaces) had partially retained sealant, 26% (54 teeth surfaces) showed caries prevention, and 49.6% (119 tooth surfaces) were carious or filled. There was no difference between teeth sealed with primer and bond (120 teeth) and teeth sealed without primer and bond (120 teeth) in completely retained sealant (p = 0.15), complete or partial sealant retention (p = 0.6), caries prevented (p = 0.37), and caries (p = 0.93). CONCLUSION: Caries prevention was not enhanced in teeth sealed with primer and bond sealant compared with those sealed with sealant alone.


Assuntos
Bis-Fenol A-Glicidil Metacrilato/uso terapêutico , Cárie Dentária/prevenção & controle , Selantes de Fossas e Fissuras/uso terapêutico , Cimentos de Resina/uso terapêutico , Bis-Fenol A-Glicidil Metacrilato/administração & dosagem , Criança , Feminino , Humanos , Kuweit , Masculino , Diques de Borracha
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