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1.
J Asthma ; 59(10): 2091-2099, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34641750

RESUMO

OBJECTIVE: Maternal asthma often complicates pregnancy and is linked with poorer quality of life. Additionally, individuals with asthma are at an increased risk of depression and anxiety. We examined whether asthma during pregnancy is related to parenting stress in the first year postpartum and if this relationship varies with level of asthma control. METHODS: This cohort survey-based study included mothers with (n = 157) and without (n = 79) asthma. Mothers with asthma participated in this study following participation in a randomized controlled trial of a novel asthma management strategy during pregnancy. Mothers completed the Parenting Stress Index - Short Form during the first 12 months postpartum. Mothers with asthma also completed the Asthma Control Questionnaire. RESULTS: Parenting stress did not differ between mothers with and without asthma. Additionally, for mothers with asthma, there were no differences in levels of parenting stress based on asthma control. CONCLUSIONS: This study suggests that mothers with asthma are not at an increased risk for excessive parenting stress. However, due to response and sampling bias, levels of parenting stress in asthmatic mothers may be underreported in our sample.


Assuntos
Asma , Poder Familiar , Asma/epidemiologia , Feminino , Humanos , Período Pós-Parto , Gravidez , Qualidade de Vida , Estresse Psicológico/complicações , Estresse Psicológico/epidemiologia
2.
Bioorg Med Chem Lett ; 22(12): 4133-8, 2012 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-22578458
4.
Eur J Pharmacol ; 531(1-3): 41-6, 2006 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-16438957

RESUMO

To investigate how specific amino acid residues affect human cannabinoid CB1 receptor binding and activation, CHO cell lines stably expressing wild type and the phenylalanine 200 to alanine mutant of human cannabinoid CB1 receptor (F200A) were examined. AM2233 functions as an agonist at the wild type receptor (EC50=0.93 nM), but behaves as an inverse agonist at F200A (EC50=4.8 nM). The F200A mutant has significantly lower forskolin-stimulated basal cAMP accumulation than that of the wild type, indicating that the F200A mutant possesses higher constitutive activity. F200 doesn't contribute substantially to the high affinity binding of AM2233 at human cannabinoid CB1 receptor. CP55940, HU-210 and Win55212-2 still function as agonists at the F200A mutant, with similar efficacy, potency, and apparent binding affinity for both wild type human cannabinoid CB1 receptor and F200A mutant. These data indicate that the phenylalanine 200 residue in human cannabinoid CB1 receptor is involved in the receptor activation induced by a specific class of agonists, and supports a model of agonist-structure-dependent conformational changes.


Assuntos
Substituição de Aminoácidos , Indóis/farmacologia , Piperidinas/farmacologia , Receptor CB1 de Canabinoide/agonistas , Alanina/genética , Animais , Sítios de Ligação/genética , Ligação Competitiva/genética , Células CHO , Colforsina/farmacologia , Cricetinae , Cricetulus , AMP Cíclico/metabolismo , Cicloexanóis/química , Cicloexanóis/metabolismo , Cicloexanóis/farmacologia , Relação Dose-Resposta a Droga , Expressão Gênica , Humanos , Indóis/química , Indóis/metabolismo , Estrutura Molecular , Toxina Pertussis/farmacologia , Fenilalanina/genética , Piperidinas/química , Piperidinas/metabolismo , Pirazóis/química , Pirazóis/metabolismo , Pirazóis/farmacologia , Receptor CB1 de Canabinoide/genética , Receptor CB1 de Canabinoide/metabolismo , Trítio
5.
Psychiatry Res ; 120(2): 145-54, 2003 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-14527646

RESUMO

Individuals scoring high (N=32) and low (N=27) on the unusual experiences (UnEx) scale of the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) were selected from a large sample (N=265) of normal volunteer undergraduates. The high- and low-UnEx groups were compared on two tasks, random generation and memory updating, which target executive functions that inhibit prepotent responses and update current information. The groups differed only on the R measure of random generation that assesses inequality in the relative frequencies of response alternatives, a result attributed to superstitious behaviour rather than to executive deficit. The results suggest that the executive impairments previously observed in high schizotypal individuals using the Wisconsin Card Sorting Test and other measures are selective rather than global.


Assuntos
Transtornos Cognitivos/diagnóstico , Transtornos Cognitivos/etiologia , Transtornos da Memória/diagnóstico , Transtornos da Memória/etiologia , Transtornos da Percepção/diagnóstico , Transtornos da Percepção/etiologia , Transtorno da Personalidade Esquizotípica/complicações , Inquéritos e Questionários , Adulto , Análise por Conglomerados , Feminino , Humanos , Masculino , Distribuição Aleatória
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