RESUMO
Introducción: La diarrea por Clostridium difficile constituye un importante problema de salud que parece incrementarse. En nuestro estudio analizamos los cambios en la incidencia de esta infección en los últimos 11 años. Material y métodos: Estudio retrospectivo de los pacientes hospitalizados con diarrea por Clostridium difficile diagnosticados en el Hospital Universitario Marqués de Valdecilla (Santander) desde el año 2004 hasta el 2014. Resultados: Se estudió a 244 pacientes (53% varones) de 66 (DE 15) años. Los casos de adquisición hospitalaria (80%) tenían, respecto a los de adquisición comunitaria, mayor edad [67 (DE 15) vs. 63 (DE 19) años; p = 0,01], comorbilidad alta (86% hospitalarios y 75% comunitarios; p = 0,01), uso de antibióticos (95 vs. 75%; p < 0,001) e inhibidores de la bomba de protones (87 vs. 48%; p < 0,001). Se incrementaron los casos con diarrea por Clostridium difficile en los últimos 11 años. Conclusión: El perfil clínico de los pacientes con diarrea por Clostridium difficile varía según el lugar de adquisición de la infección. Aumenta la prevalencia de esta enfermedad (AU)
Introduction: Clostridium difficile associated diarrhoea is a major health problem that seems to be on the increase. In our study, we analyse the changes in the incidence of this infection over the last 11 years. Methods: A descriptive study in hospitalised patients with Clostridium difficile associated diarrhoea in University Hospital Marqués de Valdecilla (Santander, Spain) from 2004 to 2014. Results: A total of 244 adults were identified [53% men; 66 (SD 15) years]. The cases of nosocomial acquisition (80%), with respect to community acquired Clostridium difficile infection, were older [67 (SD 15) years vs. 63 (19) years; P=.01), high comorbidity (86% vs. 75%; P=.01), use of antibiotics (95% vs. 75%; P<.001) and proton pump inhibitors (87% vs. 48% P<.001). There has been an increasing incidence of Clostridium difficile associated diarrhoea in our hospital over an 11-year period. Conclusion: The clinical profile of patients with Clostridium difficile diarrhoea varies by place of acquisition of infection. The prevalence of this disease is increasing (AU)
Assuntos
Humanos , Clostridioides difficile/patogenicidade , Diarreia/microbiologia , Infecções por Clostridium/epidemiologia , Estudos Retrospectivos , IncidênciaRESUMO
INTRODUCTION: Clostridium difficile associated diarrhoea is a major health problem that seems to be on the increase. In our study, we analyse the changes in the incidence of this infection over the last 11 years. METHODS: A descriptive study in hospitalised patients with Clostridium difficile associated diarrhoea in University Hospital Marqués de Valdecilla (Santander, Spain) from 2004 to 2014. RESULTS: A total of 244 adults were identified [53% men; 66 (SD 15) years]. The cases of nosocomial acquisition (80%), with respect to community acquired Clostridium difficile infection, were older [67 (SD 15) years vs. 63 (19) years; P=.01), high comorbidity (86% vs. 75%; P=.01), use of antibiotics (95% vs. 75%; P<.001) and proton pump inhibitors (87% vs. 48% P<.001). There has been an increasing incidence of Clostridium difficile associated diarrhoea in our hospital over an 11-year period. CONCLUSION: The clinical profile of patients with Clostridium difficile diarrhoea varies by place of acquisition of infection. The prevalence of this disease is increasing.
