RESUMO
UNLABELLED: In order to establish the usefulness of EEGs for the diagnosis of headache in children and adolescents, we retrospectively reviewed the records of 425 patients referred to our Paediatric Neurology Service because of recurrent headache. EEG was recorded ictally in 40 patients and interictally in 412 subjects. CONCLUSION: Our results confirm that the EEG is a very helpful tool, particularly in migraine with aura during the ictal phase, because it shows transient abnormalities that may support the diagnosis of this form of headache. On the contrary the EEG performed during the interictal phase is most often normal or it shows aspecific abnormalities with no relationship with to features.
Assuntos
Eletroencefalografia , Cefaleia/fisiopatologia , Adolescente , Criança , Pré-Escolar , Doença Crônica , Feminino , Humanos , Masculino , Transtornos de Enxaqueca/diagnóstico , Estudos RetrospectivosRESUMO
We used phosphorus magnetic resonance spectroscopy (31P MRS) to investigate in vivo the brain and skeletal muscle energy metabolism of 15 children with migraine with aura in interictal periods. Brain 31P MRS disclosed low phosphocreatine and high inorganic phosphate contents, and high intracellular pH in all patients. Calculated [ADP] and the relative rate of mitochondrial oxidation were higher in the brain of patients than in control subjects, whereas the phosphorylation potential was lower. Brain intracellular free Mg2+ concentration was reduced by 25% in patients. Abnormal skeletal muscle mitochondrial respiration was also disclosed in 7 of 15 patients as shown by the slow rate of phosphocreatine postexercise recovery. The multisystem bioenergetic failure found in patients with juvenile migraine is comparable to that found in adults with different types of migraine.
Assuntos
Encéfalo/metabolismo , Metabolismo Energético/fisiologia , Magnésio/metabolismo , Espectroscopia de Ressonância Magnética/métodos , Transtornos de Enxaqueca/metabolismo , Músculo Esquelético/metabolismo , Adolescente , Estudos de Casos e Controles , Criança , Feminino , Humanos , Masculino , FósforoRESUMO
A linkage and association analysis was made on 14 Italian families with recurrent migraine. We analyzed five chromosomal regions surrounding the candidate genes 5HT1D (1p36.3-34.3), 5HT1B (6q13), 5HT2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM (19p13), using 29 DNA polymorphic markers. All two-point lod scores were negative, and the chi 2 sib-pair analyses were not significant, thus indicating the probable exclusion of these regions as sites of migraine genes in our population.
Assuntos
Genoma Humano , Transtornos de Enxaqueca/genética , Mapeamento Cromossômico , DNA/análise , DNA/genética , Ligação Genética , Humanos , Linhagem , Polimorfismo Genético , Receptores de Serotonina/genéticaRESUMO
Single photon emission computed tomography (SPECT) was performed on 30 juvenile patients suffering from different types of migraine with aura. SPECT was carried out only during the pain-free interval in 11 patients. The other 19 patients underwent SPECT ictally and 9 of them also interictally. During the pain-free interval, the investigation was normal in 16 of 20 cases and revealed hypoperfused areas in 4 of 20 cases. Ictally, regional cerebral blood flow (rCBF) abnormalities were found in 14 of 19 cases; hypoperfusion in 11 patients and hyperperfusion in 3 patients. In most cases, rCBF abnormalities corresponded to the topography of neurologic symptoms. Our interictal period results do not agree with the previous studies in juvenile migraineurs, while during the ictal phase we demonstrated, for the first time, significant rCBF abnormalities in juvenile patients suffering from migraine with aura.
Assuntos
Circulação Cerebrovascular , Transtornos de Enxaqueca/diagnóstico por imagem , Transtornos de Enxaqueca/fisiopatologia , Compostos de Organotecnécio , Oximas , Tomografia Computadorizada de Emissão de Fóton Único , Adolescente , Adulto , Criança , Feminino , Humanos , Masculino , Tecnécio Tc 99m ExametazimaRESUMO
We report on 83 juvenile patients with idiopathic stabbing headache, subjectively perceived as lasting from a fraction of a second to a few minutes. This sample was selected from among 2543 outpatients referred because of recurrent headache to the Paediatric Neurology Services of Ferrara and Padua (Italy). Other painful syndromes were excluded by clinical examination and appropriate tests. Idiopathic stabbing headache in the pediatric age group, contrary to the adult form, is usually not associated with other primary headache syndromes. We suggest that this clinical picture should be more clearly defined in the future, in order to better understand its relationships with other primary headaches.
Assuntos
Cefaleia/classificação , Cefaleia/fisiopatologia , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Lactente , Masculino , Recidiva , Fatores de TempoRESUMO
A case of an 11-year-old boy with recurrent migraine auras without headache is reported. Aura was preceded by an anisocoria and was characterized, besides other brain-stem signs, by confusional state. Ictal EEG recordings showed fast activity. Recognition of this finding may prevent an inappropriate diagnosis of drug ingestion. However, whether non-reactive beta activity is typical for basilar migraine remains to be determined.
Assuntos
Eletroencefalografia , Transtornos de Enxaqueca/fisiopatologia , Ritmo alfa , Anisocoria/fisiopatologia , Ritmo beta , Criança , Humanos , MasculinoRESUMO
Recently an important role for magnesium in establishing the threshold for migraine attacks has become evident. Accordingly, we measured serum and red blood cell magnesium levels in juvenile migraine patients with and without aura interictally. In comparison with normal subjects, migraineurs had significantly lower serum and red blood cell magnesium levels.
