RESUMO
Children with viral respiratory infections and healthy contacts received treatment and prophylaxis with leukocytic interferon. The results emphasize the effectiveness of treatment when interferon is given on the first or second day of the disease. In these cases the course is mild, of short duration, and without complications. Conversely, the clinical course in children who did not receive interferon was more severe; the disease lasted longer, and complications were not uncommon. Prophylactic instillation of interferon succeded in protecting 85.2 percent of contacts; those who contracted the infection had a mild disease with insignificant complications. No allergic or intoxication phenomena were observed in children receiving leukocytic interferon for treatment or prophylaxis.
Assuntos
Interferons/uso terapêutico , Infecções Respiratórias/terapia , Viroses/terapia , Administração Intranasal , Criança , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Doenças do Prematuro/terapia , Interferons/biossíntese , Leucócitos/metabolismo , Infecções Respiratórias/prevenção & controle , Viroses/prevenção & controleRESUMO
Children with respiratory virus infections and healthy contacts were given leukocytic interferon (LIF) as treatment and prophylaxis. The results emphasize the effectiveness of the treatment when LIF was given on the 1st or 2nd day after onset of illness. In these cases the course was mild, of short duration and without complications. In children who did not receive LIF, the clinical course was more severe, the disease lasted longer, and complications were not uncommon. Prophylactic instillation of LIF succeeded in preventing the disease in 85.2% of the contacts; those who contracted the infection had a mild disease with insignificant complications. No allergic or intoxication phenomena were observed in children receiving LIF.
