1.
Lupus
; 22(9): 961-6, 2013 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23894048
RESUMO
Poor specific antibody response is a well-known primary immunodeficiency that is related to hypogammaglobulinemia or common variable immunodeficiency (CVID). The co-existence of CVID or hypogammaglobulinemia and systemic lupus erythematosus (SLE) has been rarely described. In all reported cases, the diagnosis of SLE antedates CVID. We report a 15-year-old Saudi girl who was diagnosed with poor specific antibody response at age 6 years in the form of poor or no antibody response and dysgammaglobulinemia. She developed SLE with musculoskeletal and hematological manifestations, positive antinuclear antibody and high anti-dsDNA nine years later. She was treated with rituximab with good response.
Assuntos
Formação de Anticorpos/imunologia , Disgamaglobulinemia/diagnóstico , Lúpus Eritematoso Sistêmico/diagnóstico , Adolescente , Anticorpos Antinucleares/imunologia , Anticorpos Monoclonais Murinos/uso terapêutico , Disgamaglobulinemia/imunologia , Feminino , Humanos , Fatores Imunológicos/uso terapêutico , Lúpus Eritematoso Sistêmico/imunologia , Lúpus Eritematoso Sistêmico/fisiopatologia , Rituximab , Resultado do Tratamento
2.
J Allergy Clin Immunol
; 100(6 Pt 1): 850-1, 1997 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9438498