Only repeated administration of the serotonergic agonist 8-OH-DPAT improves place learning of rats subjected to fimbria-fornix transection.

Serotonergic agonists may act neuroprotectively against brain injury. This study addressed the therapeutic potential of 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT), a selective 5-HT1A/7 receptor agonist, after mechanical brain injury, and evaluated its effects in terms of acquisition of an allocentric place learning task in a water maze. Rats were divided into 6 experimental groups, three of which were subjected to bilateral transection of fimbria-fornix (FF), while three groups were given control surgery (Sham). After surgery, within both the lesioned, and sham-operated animals, respectively, one group was administered a single dose of saline, one group was given a single dose (0.5 mg/kg/b.w.) of 8-OH-DPAT, and one group was treated with daily administration of 8-OH-DPAT (0.5 mg/kg/b.w.) for eight days. The acquisition of the water maze based place learning task started on the 8th day post-surgery and continued for 20 days. The results show that the lesioned group subjected to repeated administration of 8-OH-DPAT demonstrated a significantly improved acquisition of the place learning task compared to the vehicle injected lesion group. In contrast, the lesioned group treated with a single administration displayed impaired performance compared to the baseline lesion group. There were no significant effects of the 8-OH-DPAT administration in the sham control groups. We conclude that only the repeated stimulation of the 5-HT1A/7 system was associated with beneficial, recovery enhancing effects.

Fathers' mental health as a protective factor in the relationship between maternal and child depressive symptoms.

BACKGROUND: The relationship between parental and child depressive symptoms has been found to be stronger for mothers than for fathers. Does this mean that fathers' mental health is less important in the context of child depressive symptoms? The goal of the current study is to test whether the degree of fathers' depressive symptoms moderate the relationship between mothers' and children's depressive symptoms. Our knowledge about such interaction effects between mothers' and fathers' symptoms is limited. METHODS: We examined depressive symptoms in 190 children (age 7-13, 118 boys) referred to child community clinics and their parents. Mothers and fathers reported on their own and their child's depressive symptoms, whereas children only reported on their own symptoms. RESULTS: Structural equation modeling revealed significant interaction effects of mothers' and fathers' depressive symptoms on mother- and father-reported child depressive symptoms, while no effects were found for child reports. When fathers reported few depressive symptoms for themselves, no relationship between mothers' and children's depressive symptoms was observed. The more depressive symptoms in fathers, the stronger the relationship between mothers' and children's symptoms. CONCLUSIONS: Fathers' mental health may be a protective factor in the relationship between mothers' and children's depressive symptoms. Thus, researchers and practitioners would benefit from considering not only depressive symptoms in mothers, but also in fathers, when examining and working with child depressive symptoms.