Effect of vaccine dose on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody levels in a vaccinated community in Gowa Regency, Indonesia.

BACKGROUND: The administration of the coronavirus disease 2019 (COVID-19) vaccine aims to stimulate the production of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies. This leads to an enhanced production of neutralizing antibodies (Nabs), which naturally neutralize the virus within the body, thereby reducing the risk of COVID-19 infection. This study determined the analysis of factors affecting SARS-CoV-2 antibody levels in vaccinated individuals using data from the COVID-19 Seroepidemiological Survey of Gowa Regency. METHODS AND MATERIAL: This was an analytic observational study with a cross-sectional design. The COVID-19 Seroepidemiology Survey data as a whole were 851 individuals, and in this study, the number of samples was 804 individuals from all COVID-19 Seroepidemiology Survey samples who had performed the COVID-19 vaccine in Gowa Regency, selected through purposive sampling. STATISTICAL ANALYSIS USED: Data analysis was conducted using various statistical tests, including the independent-samples t-test, Mann-Whitney test, Kruskal-Wallis test, and multiple logistic regression. Furthermore, the analysis was performed through the STATA program version 14.0. RESULTS: There was a significant influence between the history of COVID-19 infection (P = 0.0006) and dose of vaccine (P = 0.0001) with SARS-CoV-2 antibody levels in vaccinated individuals. Meanwhile, vitamin consumption and comorbid history did not affect SARS-CoV-2 antibody levels. Multivariate analysis showed that vaccine dose was the most influential variable on antibody levels (P = 0.046; Odds Ratio (OR) 0.19; 95% Confidence Interval (CI): 0.036-0.968). CONCLUSIONS: The most influential factor was the vaccine dose on SARS-CoV-2 antibody levels in community in Gowa Regency.

Analysis of temperature and humidity on dengue hemorrhagic fever in Manado Municipality.

OBJECTIVE: The aim research was to analyze the association between temperature and humidity and the incidence of dengue fever in Manado Municipality. METHODS: The research design used analytical descriptive with a cross-sectional survey approach. Data were analyzed using the Spearman rank test. RESULT: The highest temperature was in August (28.7°C), the highest humidity was January (88%), and the most DHF incidence was in January (409 cases). There is a significant association between temperature and the prevalence of DHF (p=0.000, r=-0.845). Humidity with the prevalence of DHF (p=0.000, r=0.873). CONCLUSION: It was found that two variables had a significant association between temperature and humidity on the prevalence of DHF in Manado Municipality based on observations of patterns of temperature and humidity characteristics every month during 2019.

Biomarkers of pneumonia disease in under five children in "grill culture".

OBJECTIVE: Based on data WHO in 2018, almost 802,200 cases of pneumonia occur in children. Indonesia data on Riskesdas in 2018, the increase in pneumonia with the prevalence of pneumonia based on the age group 1-4 years was 5.0. This study aims to obtain more information about biomarkers of the clinical assessment on patient cases and prevention management and then whether postpartum culture contributed to the increase in pneumonia. METHODS: The method used is a Literature review. Search for scientific articles collected through Scopus indexed journals through Science Direct, Pubmed, Elsevier, MDPI, WHO, Riskesdas, Google Scholar. RESULT: From the literature articles we read, it shows that the incidence of pneumonia increases from year to year and is the leading cause of death. So it needs prevention from use biomarkers as markers and examined the association of Grill Culture with pneumonia in children under five. CONCLUSION: The results of the biomarker examination are a marker of the case and prevention management will be carried out using existing cultural approaches.

Analysis of temperature and humidity on dengue hemorrhagic fever in Manado Municipality

Objective: The aim research was to analyze the association between temperature and humidity and the incidence of dengue fever in Manado Municipality. Methods: The research design used analytical descriptive with a cross-sectional survey approach. Data were analyzed using the Spearman rank test. Result: The highest temperature was in August (28.7 °C), the highest humidity was January (88%), and the most DHF incidence was in January (409 cases). There is a significant association between temperature and the prevalence of DHF (p = 0.000, r = −0.845). Humidity with the prevalence of DHF (p = 0.000, r = 0.873). Conclusion: It was found that two variables had a significant association between temperature and humidity on the prevalence of DHF in Manado Municipality based on observations of patterns of temperature and humidity characteristics every month during 2019. (AU)

Biomarkers of pneumonia disease in under five children in “grill culture”

Objective: Based on data WHO in 2018, almost 802,200 cases of pneumonia occur in children. Indonesia data on Riskesdas in 2018, the increase in pneumonia with the prevalence of pneumonia based on the age group 1–4 years was 5.0. This study aims to obtain more information about biomarkers of the clinical assessment on patient cases and prevention management and then whether postpartum culture contributed to the increase in pneumonia. Methods: The method used is a Literature review. Search for scientific articles collected through Scopus indexed journals through Science Direct, Pubmed, Elsevier, MDPI, WHO, Riskesdas, Google Scholar. Result: From the literature articles we read, it shows that the incidence of pneumonia increases from year to year and is the leading cause of death. So it needs prevention from use biomarkers as markers and examined the association of Grill Culture with pneumonia in children under five. Conclusion: The results of the biomarker examination are a marker of the case and prevention management will be carried out using existing cultural approaches. (AU)