RESUMO
An evaluation of correlation between fatty acid composition in pulmonary surfactant lipids and 137Cs content in the body of children, residents of radiation-contaminated areas revealed that a increased incorporation of 137Cs promotes a disruption of fatty acid balance towards an increase in the saturation of the surfactant lipid complex, a destruction of lecithin fraction of surfactant, a decrease in antioxidant properties of surfactant system, an activation of lipid peroxidation processes in the respiratory area of lung by lipoxygenase type, a disturbance of polyunsaturated fatty acid metabolism on the stage of bioregulators-eicosanoid formation.
Assuntos
Radioisótopos de Césio/análise , Acidente Nuclear de Chernobyl , Ácidos Graxos Insaturados/análise , Ácidos Graxos/análise , Metabolismo dos Lipídeos/efeitos da radiação , Pulmão/efeitos da radiação , Surfactantes Pulmonares/efeitos da radiação , Criança , Eicosanoides/análise , Radiação Eletromagnética , Expiração , Ácidos Graxos/química , Ácidos Graxos Insaturados/química , Humanos , Lecitinas/análise , Peroxidação de Lipídeos/efeitos da radiação , Lipoxigenases/metabolismo , Pulmão/metabolismo , Surfactantes Pulmonares/química , Doses de Radiação , Radiometria , UcrâniaRESUMO
During application of BAA "Glucorn" for the correction of fatty-acid composition of pulmonary surfactant lipids in children-residents of radiation contaminated territories detected changes, evidence about increasing adaptation-compensatory processes in lipid membrane structures of pulmonary surfactant and respiratory tracts epithelium, activation of enzymatic pathway conversion of polyunsaturated fatty acids in their derivations--eicosanoids in absence the changes lipid peroxydation.
Assuntos
Acidente Nuclear de Chernobyl , Ácidos Graxos/metabolismo , Surfactantes Pulmonares/metabolismo , Lesões por Radiação/tratamento farmacológico , Lesões por Radiação/metabolismo , Poluentes Radioativos/intoxicação , Adolescente , Criança , Feminino , Humanos , Peroxidação de Lipídeos/efeitos dos fármacos , Peroxidação de Lipídeos/efeitos da radiação , Masculino , Lipídeos de Membrana/metabolismo , UcrâniaRESUMO
The differences in the fat acid spectrum of expired air condensate in children with recurrent bronchitis who are residents of the radiation contaminated territories and children with analogous diagnosis living in the "clear" region regarding the radionuclide contamination consisted in the increased saturation of lipid complex indices against the decrease in content of polyunsaturated fat acids, antioxidant properties of pulmonary surfactant and activity of adaptation-compensatory processes in lipid bilayer of its membrane structures.
