1.
Bioorg Med Chem Lett
; 17(21): 5974-7, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17870533
RESUMO
The synthesis of 6-epi-COTC, a diastereoisomer of Streptomyces metabolite 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC), is described. The anti-cancer activities of the novel analogue, in racemic and enantiomerically pure forms, are presented.
Assuntos
Antineoplásicos/química , Cicloexanonas/química , Cristalografia por Raios X , Espectroscopia de Ressonância Magnética , Modelos Moleculares
2.
Bioorg Med Chem Lett
; 17(2): 553-7, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17174551
RESUMO
The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung cancer cell lines are presented.