RESUMO
Bone marrow aplasia is a frequent complication of colchicine poisoning. This typically occurs on day 3 to 5 postexposure, and the blood cell counts remain depressed for a week or more. Unfortunately, because patients suffering from colchicine toxicity develop multiple organ complications and sepsis, the morbidity and mortality associated with bone marrow depression is high. In this article, we present three cases of colchicine toxicity in which granulocyte colony-stimulating factor (G-CSF) was used to treat bone marrow depression. In all three cases, there was a dramatic increase in the white cell count and, to a lesser extent, the platelet count. In view of the critical nature of the bone marrow depression and multi-organ toxicity induced by colchicine, we believe that consideration of the use of G-CSF to shorten the duration of neutropenia is warranted.
Assuntos
Anemia Aplástica/induzido quimicamente , Anemia Aplástica/terapia , Colchicina/intoxicação , Tratamento de Emergência/métodos , Fator Estimulador de Colônias de Granulócitos/uso terapêutico , Tentativa de Suicídio , Adolescente , Adulto , Anemia Aplástica/sangue , Anemia Aplástica/diagnóstico , Exame de Medula Óssea , Colchicina/química , Colchicina/farmacologia , Feminino , Hidratação/métodos , Lavagem Gástrica , Humanos , Contagem de Leucócitos/efeitos dos fármacos , Contagem de Plaquetas/efeitos dos fármacosRESUMO
A 44-year-old man suffered a life-threatening anaphylactoid reaction to polyvalent snake antivenom, although he had been given the recommended pretreatment. Further research is needed to determine if pretreatment is necessary.
