RESUMO
Aerial parts of the plant Sida rhombifolia Linn. (Malvaceae) were extracted successively to produce various extracts. These extracts were screened for various parameters of anti-arthritic activity, such as adjuvant-induced arthritis, motor performance, mean distance travelled, and histopathological study. Results showed that the polar constituents (ethanol and aqueous extracts) of the plant S. rhombifolia were useful in the treatment of arthritis.
Assuntos
Articulação do Joelho/efeitos dos fármacos , Malvaceae/química , Atividade Motora/efeitos dos fármacos , Componentes Aéreos da Planta/química , Extratos Vegetais/farmacologia , Animais , Artrite Experimental/tratamento farmacológico , Artrite Experimental/patologia , Articulação do Joelho/patologia , Masculino , Ratos , Ratos WistarRESUMO
To overcome the relatively short gastrointestinal (GI) time and improve localization for oral controlled or sustained release drug delivery systems, bioadhesive polymers that adhere to the mucin/epithelial surface are effective and lead to significant improvement in oral drug delivery. Improvements are also expected for other mucus-covered sites of drug administration. Bioadhesive polymers find application in the eye, nose, and vaginal cavity as well as in the GI tract, including the buccal cavity and rectum. This article lays emphasis mainly on mucoadhesive polymers, their properties, and their applications in buccal, ocular, nasal, and vaginal drug delivery systems with its evaluation methods.
