Assuntos
Carcinoma de Células de Transição/complicações , Gastroenteropatias/etiologia , Recidiva Local de Neoplasia/complicações , Neoplasias da Bexiga Urinária/complicações , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma de Células de Transição/secundário , Carcinoma de Células de Transição/terapia , Colostomia , Terapia Combinada , Diagnóstico por Imagem , Evolução Fatal , Humanos , Masculino , Pessoa de Meia-Idade , Terapia de Salvação , Neoplasias da Bexiga Urinária/terapiaAssuntos
Doença Diverticular do Colo/complicações , Doenças das Tubas Uterinas/etiologia , Fístula/etiologia , Doenças do Colo Sigmoide/etiologia , Doença Aguda , Idoso , Doença Diverticular do Colo/diagnóstico , Doenças das Tubas Uterinas/diagnóstico , Feminino , Fístula/diagnóstico , Humanos , Fístula Intestinal/diagnóstico , Fístula Intestinal/etiologia , Doenças do Colo Sigmoide/diagnósticoRESUMO
Genome-wide association studies (GWAS) have successfully identified genetic variants associated with risk for breast cancer. However, the molecular mechanisms through which the identified variants confer risk or influence phenotypic expression remains poorly understood. Here, we present a novel integrative genomics approach that combines GWAS information with gene expression data to assess the combined contribution of multiple genetic variants acting within genes and putative biological pathways, and to identify novel genes and biological pathways that could not be identified using traditional GWAS. The results show that genes containing SNPs associated with risk for breast cancer are functionally related and interact with each other in biological pathways relevant to breast cancer. Additionally, we identified novel genes that are co-expressed and interact with genes containing SNPs associated with breast cancer. Integrative analysis combining GWAS information with gene expression data provides functional bridges between GWAS findings and biological pathways involved in breast cancer.