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1.
Phytother Res ; 36(7): 2839-2851, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35567294

RESUMO

Myristica fragrans (Houtt.) is an evergreen tree native to the Maluku Islands, Indonesia. M. fragrans kernel is extensively used in Indian traditional medicines to treat various diseases. Several studies attempt to compile and interpret the pharmacological potential of Myristica fragrans (Houtt.) aqueous and various chemical extracts. Thus, the pharmacological potential of nutmeg essential oil has not been reviewed phytochemically and pharmacologically. Therefore, the present study aimed to share appropriate literature evidence regarding the plant essential oil chemical composition and therapeutic potential of Myristica fragrans essential oil (MFEO). MFEO of leaf, mace, kernel, and seed were used worldwide as potential Ayurvedic medicine and fragrance. MFEO extracted by various methods and oil yield was 0.7-3.2, 8.1-10.3, 0.3-12.5, and 6.2-7.6% in leaf, mace, seed, and kernel. The primary chemical constituents of MFEO were sabinene, eugenol, myristicin, caryophyllene, ß-myrcene, and α-pinene. Clinical and experimental investigations have confirmed the antioxidant, antimicrobial, antiinflammatory, anticancer, antimalarial, anticonvulsant, hepatoprotective, antiparasitic, insecticidal, and nematocidal activities of MFEO. It is the first attempt to compile oil yield, composition, and the biological activities of MFEO. In future, several scientific investigations are required to understand the mechanism of action of MFEO and their bioactive constituents.


Assuntos
Anti-Infecciosos , Myristica , Óleos Voláteis , Antioxidantes/análise , Myristica/química , Óleos Voláteis/química , Óleos Voláteis/farmacologia , Extratos Vegetais/química , Sementes/química
2.
Nat Prod Res ; 36(1): 432-435, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32515616

RESUMO

The essential oil (EO) from leaf, mace, kernel, and seed of Myristica fragrans Houtt. growing in the Western Ghats, India was investigated for the first time. The EO was extracted by hydrodistillation and analysed by GC-MS. The results revealed that yields of EO were 3.16%, 8.10%, 6.24%, and 5.21% for leaf, mace, kernel, and seed, respectively. The main fractions were found to be monoterpenes (53.77%-94.82%), phenylpropenes (1.96%-28.61%), and sesquiterpenes (1.21%-16.76%) and for all the four parts. The main constituents of leaf were sabinene (17.17%), eugenol (16.60%), myristicin (9.12%), caryophyllene (8.82%), and ß-myrcene (4.74%). Sabinene (38.37%), α-pinene (8.16%), ß-pinene (7.61%), D-limonene (7.07%), and 3-carene (5.05%) were predominant constituents of mace. The major constituents of kernel and seed were sabinene, α-pinene, ß-pinene, and D-limonene. The major constituents of leaf, mace, kernel and seed of nutmeg can be utilised in the food, perfumery, aroma and pharmaceutical industries.


Assuntos
Myristica , Óleos Voláteis , Cromatografia Gasosa-Espectrometria de Massas , Monoterpenos/análise , Folhas de Planta/química
3.
Front Nutr ; 7: 599119, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33363195

RESUMO

Rice (Oryza sativa L.) is one of the major cereal crops cultivated across the world, particularly in Southeast Asia with 95% of global production. The present study was aimed to evaluate the total phenolic content (TPC) and to profile all the volatile organic compounds (VOCs) of eight popular traditional and two modern rice varieties cultivated in South India. Thirty-one VOCs were estimated by gas chromatography-mass spectrometry (GC-MS). The identified volatile compounds in the 10 rice varieties belong to the chemical classes of fatty acids, terpenes, alkanes, alkenes, alcohols, phenols, esters, amides, and others. Interestingly, most of the identified predominant components were not identical, which indicate the latent variation among the rice varieties. Significant variations exist for fatty acids (46.9-76.2%), total terpenes (12.6-30.7%), total phenols (0.9-10.0%), total aliphatic alcohols (0.8-5.9%), total alkanes (0.5-5.1%), and total alkenes (1.0-4.9%) among the rice varieties. Of all the fatty acid compounds, palmitic acid, elaidic acid, linoleic acid, and oleic acid predominantly varied in the range of 11.1-33.7, 6.1-31.1, 6.0-28.0, and 0.7-15.1%, respectively. The modern varieties recorded the highest palmitic acid contents (28.7-33.7%) than the traditional varieties (11.1-20.6%). However, all the traditional varieties had higher linoleic acid (10.0-28.0%) than the modern varieties (6.0-8.5%). Traditional varieties had key phenolic compounds, stearic acid, butyric acid, and glycidyl oleate, which are absent in the modern varieties. The traditional varieties Seeraga samba and Kichilli samba had the highest azulene and oleic acid, respectively. All these indicate the higher variability for nutrients and aroma in traditional varieties. These varieties can be used as potential parents to improve the largely cultivated high-yielding varieties for the evolving nutritional market. The hierarchical cluster analysis showed three different clusters implying the distinctness of the traditional and modern varieties. This study provided a comprehensive volatile profile of traditional and modern rice as a staple food for energy as well as for aroma with nutrition.

4.
Front Genet ; 11: 414, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32547594

RESUMO

Globally, two billion people suffer from micronutrient deficiencies. Cereal grains provide more than 50% of the daily requirement of calories in human diets, but they often fail to provide adequate essential minerals and vitamins. Cereal crop production in developing countries achieved remarkable yield gains through the efforts of the Green Revolution (117% in rice, 30% in wheat, 530% in maize, and 188% in pearl millet). However, modern varieties are often deficient in essential micronutrients compared to traditional varieties and land races. Breeding for nutritional quality in staple cereals is a challenging task; however, biofortification initiatives combined with genomic tools increase the feasibility. Current biofortification breeding activities include improving rice (for zinc), wheat (for zinc), maize (for provitamin A), and pearl millet (for iron and zinc). Biofortification is a sustainable approach to enrich staple cereals with provitamin A, carotenoids, and folates. Significant genetic variation has been found for provitamin A (96-850 µg and 12-1780 µg in 100 g in wheat and maize, respectively), carotenoids (558-6730 µg in maize), and folates in rice (11-51 µg) and wheat (32.3-89.1 µg) in 100 g. This indicates the prospects for biofortification breeding. Several QTLs associated with carotenoids and folates have been identified in major cereals, and the most promising of these are presented here. Breeding for essential nutrition should be a core objective of next-generation crop breeding. This review synthesizes the available literature on folates, provitamin A, and carotenoids in rice, wheat, maize, and pearl millet, including genetic variation, trait discovery, QTL identification, gene introgressions, and the strategy of genomics-assisted biofortification for these traits. Recent evidence shows that genomics-assisted breeding for grain nutrition in rice, wheat, maize, and pearl millet crops have good potential to aid in the alleviation of micronutrient malnutrition in many developing countries.

5.
J Ethnopharmacol ; 246: 112244, 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-31541721

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Small cardamom [Elettaria cardamomum (L.) Maton. (Family: Zingiberaceae)] capsules (fruits) have been used for traditional medicine applications including for the control of asthma, teeth and gum infections, cataracts, nausea, diarrhea, as well as cardiac, digestive and kidney disorders. The versatile use of cardamom capsules has several other beneficial health effects that are relevant in light of traditional and modern pharmaceutical perspectives. AIM OF THE STUDY: This review aims to provide a critical and comprehensive evaluation of the traditional and current medical uses of E. cardamomum, and compare these applications with modern research studies. This critical review also discusses the botanical distribution, phytochemical constituents and biological activities of cardamom capsule extracts and essential oil. MATERIALS AND METHODS: An online survey was conducted of the traditional uses, phytochemical composition, and pharmacological applications of cardamom essential oil (CEO) and extracts. Pertinent data were obtained from several electronic scientific databases (Science Direct, Elsevier, Web of Science, PubMed, Springer, ACS publications, Taylor and Francis, Wiley On-line Library and Google Scholar), and additional information was obtained from textbooks and local prints and scripts. RESULTS: Cardamom fruits (capsules) are used widely as a spice and flavoring ingredient in foods, and are often recognized for their beneficial health properties. They are also used in fragrances. Phytochemical analyses have described important chemical constituents of cardamom including carbohydrates, proteins, minerals, lipids, essential oils, flavonoids, terpenoids and carotenoids. CEO has several biological roles including antioxidant, antidiabetic, antibacterial, anticancer, gastro-protective and insecticidal activities. CONCLUSION: The widespread availability and recommendation of synthetic compounds for addressing human health have several side effects besides higher costs. Hence, examining natural bioactive compounds is imperative. This review investigates and presents the pertinent information on cardamom and its traditional uses, as well as potential pharmacological properties of CEO and extracts. Additional research studies are needed to understand the mechanism of action of bioactive constituents.


Assuntos
Elettaria/química , Elettaria/fisiologia , Animais , Humanos , Medicina Tradicional , Compostos Fitoquímicos , Plantas Medicinais
6.
Nat Prod Res ; 34(13): 1919-1922, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30663385

RESUMO

Elettaria cardamomum (L.) Maton prestigiously called as Indian cardamom and is mostly cultivated in south India at higher altitudes ranging from 900 to 1400 msl. The chemical composition of dry capsules essential oil of the four distinct varieties was chemo-profiled by gas chromatography-mass spectrometry (GC-MS). Results revealed a higher concentration of major monoterpene 1, 8-Cineole ranging between 28.94% and 34.91% in PV 1 and PV 2 varieties respectively. Other monoterpenes like α-Pinene, Sabinene, Linalool, α-Terpineol and Nerol were present considerable quantities in all of the four cardamom varieties. Two sesquiterpenic constituents namely, ç-Elemene and 1,6,10-dodecatrien-3-ol (Nerolidol) were identified in all varieties. Three ester constituents were also obtained in PV 1 in which α-Terpinyl acetate (26.68%) exhibited as a major ester constituent followed by Ocimenyl acetate (0.80%) and E5-Dodecenyl acetate (0.30%). This is the first published report on the phytochemical concentration of recent varieties of Indian cardamom.[Formula: see text].


Assuntos
Elettaria/química , Monoterpenos/análise , Compostos Fitoquímicos/análise , Monoterpenos Acíclicos/análise , Monoterpenos Bicíclicos/análise , Monoterpenos Cicloexânicos/análise , Eucaliptol/análise , Cromatografia Gasosa-Espectrometria de Massas , Índia , Óleos Voláteis/análise , Óleos Voláteis/química
7.
Nat Prod Res ; 34(9): 1306-1310, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-30672326

RESUMO

The objective of this study was to examine the bioactive flavonoids and carotenoids concentration in fifteen south Indian spice and two tree nut species using high performance liquid chromatography (HPLC). Among four flavonoids, catechin concentration was the highest in all spices and nuts and ranged between 97.1 and 1745.4 µg g-1. Quercetin concentration was the greatest in cinnamon, followed by garlic and cumin and ranged from 0.4 to 65 µg g-1 in other spices and nuts. Lutein concentration ranged from 0.1 to 102.8 µg g-1. Of the spices and nuts studied, ß-carotene concentration was highest in coriander leaves (74.7 µg g-1), followed by red pepper (12.5 µg g-1) and curry leaves (8.5 µg g-1). This research shows that consumption of south Indian spices and nuts could substantially benefit consumers living in regions experiencing Vitamin A and other micronutrient deficiencies.


Assuntos
Carotenoides/análise , Flavonoides/análise , Especiarias , Antioxidantes/análise , Capsicum/química , Cromatografia Líquida de Alta Pressão/métodos , Coriandrum/química , Alho/química , Índia , Nozes/química
8.
Nat Prod Res ; 32(14): 1733-1737, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29058482

RESUMO

The genetic potential and biofortification of India-grown rice with bioavailable folate has not been studied yet. The objectives of this study were to determine the folates concentration in four cultivars of rice through UPLC-MS/MS. Total folate concentration in rice cultivars ranged from 11.0 to 51 µg/100 g with a mean of 26.0 µg/100 g. Among the four rice cultivars, the pigmented grain cultivar Nootripathu possesses two-fold rich sources of total folates than the other three non-pigmented grain cultivars. The average value of 100 g serving of rice grains could provide the amount of recommended daily allowance (% RDA) of dietary folates (6.5%) for adults, which ranged from 2.7-12.7%. Among the 5 individual forms of folates, 5-methyltetrahydrofolate was most abundant in rice cultivars followed by 10-Formylfolic acid and folic acid. The result of this study has been useful for biofortification of folates in rice.


Assuntos
Ácido Fólico/análise , Oryza/química , Sementes/química , Cromatografia Líquida/métodos , Ácido Fólico/análogos & derivados , Ácido Fólico/química , Índia , Recomendações Nutricionais , Espectrometria de Massas em Tandem , Tetra-Hidrofolatos/análise
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